ID C4F7F3_9ACTN Unreviewed; 1179 AA.
AC C4F7F3;
DT 07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 07-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 79.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=COLINT_01968 {ECO:0000313|EMBL:EEP45176.1};
OS Collinsella intestinalis DSM 13280.
OC Bacteria; Actinomycetota; Coriobacteriia; Coriobacteriales;
OC Coriobacteriaceae; Collinsella.
OX NCBI_TaxID=521003 {ECO:0000313|EMBL:EEP45176.1, ECO:0000313|Proteomes:UP000003295};
RN [1] {ECO:0000313|EMBL:EEP45176.1, ECO:0000313|Proteomes:UP000003295}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 13280 {ECO:0000313|EMBL:EEP45176.1,
RC ECO:0000313|Proteomes:UP000003295};
RA Weinstock G., Sodergren E., Clifton S., Fulton L., Fulton B., Courtney L.,
RA Fronick C., Harrison M., Strong C., Farmer C., Delahaunty K., Markovic C.,
RA Hall O., Minx P., Tomlinson C., Mitreva M., Nelson J., Hou S., Wollam A.,
RA Pepin K.H., Johnson M., Bhonagiri V., Nash W.E., Warren W., Chinwalla A.,
RA Mardis E.R., Wilson R.K.;
RL Submitted (APR-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EEP45176.1}.
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DR EMBL; ABXH02000002; EEP45176.1; -; Genomic_DNA.
DR RefSeq; WP_006722216.1; NZ_GG692710.1.
DR AlphaFoldDB; C4F7F3; -.
DR STRING; 521003.COLINT_01968; -.
DR eggNOG; COG1074; Bacteria.
DR HOGENOM; CLU_001114_1_3_11; -.
DR Proteomes; UP000003295; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR Gene3D; 3.30.160.800; -; 1.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}.
FT DOMAIN 4..416
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 432..715
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT REGION 956..1008
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 25..32
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1179 AA; 126848 MW; 068EB7147E47C5C0 CRC64;
MDLSTLMPQQ RDIVTTLDRP LFVSAGAGSG KTFTLTRRIL WALSPESGPF IRNLDRVLAI
TFTKDAAAEI RERVRGALIE EGMGDIALQV DDAWISTIHG MCSRILRAHA LELGLDPEFS
VLDESVSGPL MDRAVDAVIA RERGGLRELQ EWYALSGELD PSGFEAGTSA KRLVRTLLER
ASASRHGFDD MHLIRGSVDF SGLMDAYRQC LGASAKAAET ARIALDALEA YGCGPQTRGD
LAACMLACGM PRPSKAFPKE QVALLKAEAA DAFINAYLAL GGSALDELLA LARAVGDEYA
ALKAERSALD NNDLLRLTYE ALRDHPRIRD AYAGKFAMVM IDEFQDTDQQ QVDLINFLTG
EGGRALCTVG DAQQSIYRFR GAEVEVFRRA QRRIEQGAAA GSEGSVVKLV KNFRSHAEVL
EYVARVFDDG QGGIMPSFLN LLPHDGRADG LRVAGASRRQ ALLVAGGTTE ERTAAKAEAI
AKRFRALADA GQPAGDMVLL LGGMTRAGVY ADAIRAQGLD CVISGGSVFA STEEAKTIRA
LVHMLGNLAD TAQGLAPVLA SPLFALGVQE FLALATAWDA QTGETRRRNI ELGILFDDDA
PGFGDLPLLA RARTVLRRAL SRLGKDPLAS IVRDVVNESG WMVRLAERGA EGRAQAANVL
KAIDAVAEAE AELGNAPRQV ALAYDRFLTG KQAPGALNEE GGNAVRIMTV HASKGLEFPV
VAVSECFGIR SNSARMQSVR RDDGTLDLVA LPGRFPDCRD SLGSLIEGAE VEKQFKRYLS
GSGATGPWLD ASLVDDVCAT GSAAEAWLSM RDEEDRLALE ERARLLYVAM TRAREVCLLA
MDAPVGRGKG SALALKPELD LTPAVLERIL PDAGASLACD RLVFDNAQAG DFELIALRDF
SYGGVVYEAN AALADAEDPV ADVPVSEPMD SFTLVEPANV YMRVVPAERA PRDSYSYSSV
SAELHEEAED HPEPTEAPIE GASGEAAVSG GVEAPRDERA VPSHEGDPTA LGSAFHAACQ
WLIELDRADL PVERADALCR YWGCTAAQRE RFDEAVARWL SSDVRAEALA WPCRRAEVPF
YSLGMDGLVE RFGPYAEGAI DLLCTDAARP GRALLIDYKT GGSSLETPEQ LQEKHALQAS
VYADVLHKAG YEQVTLKFVR VEVPDPSDPT QPQVVTYEL
//