ID   C4IHF8_CLOBU            Unreviewed;       399 AA.
AC   C4IHF8;
DT   07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   07-JUL-2009, sequence version 1.
DT   24-JAN-2024, entry version 47.
DE   SubName: Full=Saccharopine dehydrogenase {ECO:0000313|EMBL:EEP54186.1};
DE            EC=1.5.1.7 {ECO:0000313|EMBL:EEP54186.1};
GN   ORFNames=CLP_3119 {ECO:0000313|EMBL:EEP54186.1};
OS   Clostridium butyricum E4 str. BoNT E BL5262.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=632245 {ECO:0000313|EMBL:EEP54186.1, ECO:0000313|Proteomes:UP000003081};
RN   [1] {ECO:0000313|EMBL:EEP54186.1, ECO:0000313|Proteomes:UP000003081}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=E4 str. BoNT E BL5262 {ECO:0000313|Proteomes:UP000003081};
RA   Shrivastava S., Brinkac L.B., Brown J.L., Bruce D.B., Detter C.,
RA   Green L.D., Munk C.A., Rogers Y.C., Tapia R., Sims D.R., Smith L.A.,
RA   Smith T.J., Sutton G., Brettin T.;
RL   Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EEP54186.1}.
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DR   EMBL; ACOM01000005; EEP54186.1; -; Genomic_DNA.
DR   RefSeq; WP_003408354.1; NZ_ACOM01000005.1.
DR   AlphaFoldDB; C4IHF8; -.
DR   STRING; 1492.ATN24_14665; -.
DR   GeneID; 66380658; -.
DR   eggNOG; COG1748; Bacteria.
DR   HOGENOM; CLU_032114_0_0_9; -.
DR   Proteomes; UP000003081; Unassembled WGS sequence.
DR   GO; GO:0004754; F:saccharopine dehydrogenase (NAD+, L-lysine-forming) activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR032095; Sacchrp_dh-like_C.
DR   InterPro; IPR005097; Sacchrp_dh_NADP.
DR   PANTHER; PTHR43796; CARBOXYNORSPERMIDINE SYNTHASE; 1.
DR   PANTHER; PTHR43796:SF2; CARBOXYNORSPERMIDINE SYNTHASE; 1.
DR   Pfam; PF16653; Sacchrp_dh_C; 1.
DR   Pfam; PF03435; Sacchrp_dh_NADP; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000313|EMBL:EEP54186.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000003081}.
FT   DOMAIN          5..136
FT                   /note="Saccharopine dehydrogenase NADP binding"
FT                   /evidence="ECO:0000259|Pfam:PF03435"
FT   DOMAIN          140..386
FT                   /note="Saccharopine dehydrogenase-like C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF16653"
SQ   SEQUENCE   399 AA;  44873 MW;  1DF89DF081C87838 CRC64;
     MGRALIIGAG GVASVAIHKC CQNSEVFEEI CIASRTLSKC DALKEKLQGG KTKIQTAKVD
     ADNVDELVAL INDFKPDVVI NLALPYQDLT IMDACLATKV HYVDTANYEP LDTAKFEYKW
     QWEYRERFEK AGITALLGSG FDPGVTGVFS AYAQKHYFDE IHYIDIVDAN AGDHGYPFAT
     NFNPEINIRE ITANGSYWED GKWVETKPLE LKEVYDLPQI GPKDVYLLHH EELESLGLNI
     KGIKRIRFWM TFSEKYLTHL KVLENVGMTS IEPIEFEGQK IVPLQFLKAV LPDPASLGPR
     TKGKTNIGCI FQGIKDGEPK TYYVYNVCDH EACYKEVGSQ AISYTTGVPA MIGASMILKG
     LWNKPGVHNI EEFDPDPFME ELNKWGLPWI EDFNPTLIK
//