ID C4IIU2_CLOBU Unreviewed; 658 AA.
AC C4IIU2;
DT 07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 07-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=GTP-binding elongation factor, TetM/TetO family {ECO:0000313|EMBL:EEP55046.1};
GN ORFNames=CLP_2328 {ECO:0000313|EMBL:EEP55046.1};
OS Clostridium butyricum E4 str. BoNT E BL5262.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=632245 {ECO:0000313|EMBL:EEP55046.1, ECO:0000313|Proteomes:UP000003081};
RN [1] {ECO:0000313|EMBL:EEP55046.1, ECO:0000313|Proteomes:UP000003081}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=E4 str. BoNT E BL5262 {ECO:0000313|Proteomes:UP000003081};
RA Shrivastava S., Brinkac L.B., Brown J.L., Bruce D.B., Detter C.,
RA Green L.D., Munk C.A., Rogers Y.C., Tapia R., Sims D.R., Smith L.A.,
RA Smith T.J., Sutton G., Brettin T.;
RL Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Abolishes the inhibitory effect of tetracyclin on protein
CC synthesis by a non-covalent modification of the ribosomes.
CC {ECO:0000256|ARBA:ARBA00003987}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EEP55046.1}.
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DR EMBL; ACOM01000005; EEP55046.1; -; Genomic_DNA.
DR RefSeq; WP_002579813.1; NZ_ACOM01000005.1.
DR AlphaFoldDB; C4IIU2; -.
DR STRING; 1492.ATN24_08525; -.
DR eggNOG; COG0480; Bacteria.
DR HOGENOM; CLU_002794_5_1_9; -.
DR Proteomes; UP000003081; Unassembled WGS sequence.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR CDD; cd03711; Tet_C; 1.
DR CDD; cd04168; TetM_like; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.70.240; -; 1.
DR Gene3D; 3.30.70.870; Elongation Factor G (Translational Gtpase), domain 3; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR InterPro; IPR035647; EFG_III/V.
DR InterPro; IPR000640; EFG_V-like.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR035650; Tet_C.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR005517; Transl_elong_EFG/EF2_IV.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR43261:SF1; RIBOSOME-RELEASING FACTOR 2, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43261; TRANSLATION ELONGATION FACTOR G-RELATED; 1.
DR Pfam; PF00679; EFG_C; 1.
DR Pfam; PF03764; EFG_IV; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR PRINTS; PR01037; TCRTETOQM.
DR SMART; SM00838; EFG_C; 1.
DR SMART; SM00889; EFG_IV; 1.
DR SUPFAM; SSF54980; EF-G C-terminal domain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251};
KW Elongation factor {ECO:0000313|EMBL:EEP55046.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000313|EMBL:EEP55046.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000003081}.
FT DOMAIN 1..239
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 658 AA; 75779 MW; B126E0580E74DBFE CRC64;
MKKTIGILAH VDAGKTTFSE HILYHTNSIR KCGRVDHKDT FLDNHDIERE RGITIFSEQG
VFEFNNSTYY IVDTPGHVDF STEMERSIMI MDYAVILVSA AEGVQGHTKT VWNLLRKYNI
PTFFFINKLD RVGADKKRVI GEMKKELAEN IFEIDVIMSD SKGHVNFNDE LIEFITEQDD
ELLEHYFDGN YCEEIWKRKF KTLIKECKVF PCFGGCALQD EGIVEFLFGF DELTYTTYDC
VENEKFIGKV FKVRHDDNGT RITFLKCIKG SLNVRDEVTY GKNEEEATTQ KISSIRIYNG
SKFRTCDKVT SGDIFGVLGL SKASAFDTIG EIREKDTCEM VPTLMSKVIF DKSYNVKDVL
GYFKILESED PSLNVIWNES LKELHVHIMG KIQLEILKEI VSERFNINVE FGPCEILYKE
TIKKETIGCG HFEPLRHYAE VIIKIEPMER NSGISFETCC HVDDLSINFQ KLIKSHIFER
EHHGLLTGSS ITDIKITLLN GRSHLKHTCG GDFREATYRA IRQGFEKVEN ILLEPYYKFT
IEVFQEHIGR VLTDIQRLHG TFEDPVNNEG KVIIIGRGPV STFMDYTMEI AAFTRGKGIV
NLVYDGYDLC HNSDEVIKRR DYNKNADIEY TSNSVFCSHG SGYIVEWQDA DQKMHCFK
//
