ID C4IJE9_CLOBU Unreviewed; 1187 AA.
AC C4IJE9;
DT 07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 07-JUL-2009, sequence version 1.
DT 24-JAN-2024, entry version 55.
DE RecName: Full=Chromosome partition protein Smc {ECO:0000256|HAMAP-Rule:MF_01894};
GN Name=smc {ECO:0000256|HAMAP-Rule:MF_01894,
GN ECO:0000313|EMBL:EEP54856.1};
GN ORFNames=CLP_2538 {ECO:0000313|EMBL:EEP54856.1};
OS Clostridium butyricum E4 str. BoNT E BL5262.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=632245 {ECO:0000313|EMBL:EEP54856.1, ECO:0000313|Proteomes:UP000003081};
RN [1] {ECO:0000313|EMBL:EEP54856.1, ECO:0000313|Proteomes:UP000003081}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=E4 str. BoNT E BL5262 {ECO:0000313|Proteomes:UP000003081};
RA Shrivastava S., Brinkac L.B., Brown J.L., Bruce D.B., Detter C.,
RA Green L.D., Munk C.A., Rogers Y.C., Tapia R., Sims D.R., Smith L.A.,
RA Smith T.J., Sutton G., Brettin T.;
RL Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for chromosome condensation and partitioning.
CC {ECO:0000256|HAMAP-Rule:MF_01894}.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|HAMAP-Rule:MF_01894}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01894}.
CC -!- DOMAIN: Contains large globular domains required for ATP hydrolysis at
CC each terminus and a third globular domain forming a flexible hinge near
CC the middle of the molecule. These domains are separated by coiled-coil
CC structures. {ECO:0000256|HAMAP-Rule:MF_01894}.
CC -!- SIMILARITY: Belongs to the SMC family. SMC3 subfamily.
CC {ECO:0000256|ARBA:ARBA00005917}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EEP54856.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; ACOM01000005; EEP54856.1; -; Genomic_DNA.
DR RefSeq; WP_003415523.1; NZ_ACOM01000005.1.
DR AlphaFoldDB; C4IJE9; -.
DR STRING; 1492.ATN24_07495; -.
DR eggNOG; COG1196; Bacteria.
DR HOGENOM; CLU_001042_2_2_9; -.
DR Proteomes; UP000003081; Unassembled WGS sequence.
DR GO; GO:0005694; C:chromosome; IEA:InterPro.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030261; P:chromosome condensation; IEA:InterPro.
DR GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-UniRule.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR GO; GO:0007062; P:sister chromatid cohesion; IEA:InterPro.
DR CDD; cd03278; ABC_SMC_barmotin; 2.
DR Gene3D; 1.20.1060.20; -; 1.
DR Gene3D; 3.30.70.1620; -; 1.
DR Gene3D; 6.10.140.1720; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR HAMAP; MF_01894; Smc_prok; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR003395; RecF/RecN/SMC_N.
DR InterPro; IPR024704; SMC.
DR InterPro; IPR010935; SMC_hinge.
DR InterPro; IPR036277; SMC_hinge_sf.
DR InterPro; IPR011890; SMC_prok.
DR NCBIfam; TIGR02168; SMC_prok_B; 1.
DR PANTHER; PTHR43977; STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3; 1.
DR PANTHER; PTHR43977:SF1; STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3; 1.
DR Pfam; PF06470; SMC_hinge; 1.
DR Pfam; PF02463; SMC_N; 1.
DR PIRSF; PIRSF005719; SMC; 1.
DR SMART; SM00968; SMC_hinge; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF75553; Smc hinge domain; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|HAMAP-Rule:MF_01894};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|HAMAP-
KW Rule:MF_01894};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_01894};
KW DNA-binding {ECO:0000256|HAMAP-Rule:MF_01894};
KW Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_01894};
KW Reference proteome {ECO:0000313|Proteomes:UP000003081}.
FT DOMAIN 525..642
FT /note="SMC hinge"
FT /evidence="ECO:0000259|SMART:SM00968"
FT COILED 167..194
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01894"
FT COILED 245..289
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01894"
FT COILED 318..516
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01894"
FT COILED 733..802
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01894"
FT COILED 873..944
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01894"
FT COILED 992..1033
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01894"
FT BINDING 32..39
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01894"
SQ SEQUENCE 1187 AA; 136469 MW; 82C279EB8FCCF7B4 CRC64;
MFLKSLEIRG FKSFADKTEL KFKKGVTAVV GPNGSGKSNI SDAVRWVLGE QSIKVLRGGK
MEDVIFAGTQ FRKPVGLAQV SLTLDNSDEQ LATEYNEVTV SRRIFRSGES EYLINNNKCR
LKDVTNLFMD TGIGKEGYSL IGQGKIEAIL SGKPEERRAL LEEAAGIVKF KNRKEEAEKK
LSNTDDNLVR INDILSTYEE RIEPLRIERE KAIEFKELSD NLKRKEVSLI VHTIQIMDQE
LRVFKEELNK RIEGINKKRE SIAKDKEILS NLEERIENIE KKTLGEKEQY YTLKDIINDD
GKAIELYHER IKNCEEKIKR NSYEVEDISK RMEDIENNKL LLEQELAKRF EEQADKKEII
EKLEQTNKIK QLELEKMKAE LKVLQKSELD FLRSNSDVKN EINILKRELE LREEKRQSLD
SSISYLENNI VINMATYKVL SRDIDNKKKE IEDVRNSTAE LKKRIATLKG NITKKENDVK
ELNRVLTKLD ANKTMLENLE KHYEGYNRSV KSLMESIKDE NIEGAEETKV LGEVFSVDKQ
YETALEIALG AAISNVITST EQVAKKLIIY LKKNNLGRAT FLPINIIKGK KLNLDDSITK
SEGYIGIGSD IISYDSIYEN IMNYTLGRTI ICRDMDCALK ISKISQYRYK IVTLEGEVVN
PGGALTGGSI KGRNTNLLGR KREIEEIAHK IDEKKKVYAD IMKEGQKLSL ELKEIDEEIL
NNTDLIHSKN IDLTRKQSEI EGLQNDTNKL KKTLENTRID LERIKEDKQE ISEKLNIKEN
EIRILEDENV TKKNQSVELE ELIGVKTLEV SKDESKLTEM KIAKAALDEG IEGKKNDFSR
IEKESYDLSG KRDNLVRESK ENEKSIIELN FSIKERQKNI EENNTKINIL ELNFKDDEIE
KEKLKEEFKQ KDNLISAVMD EISREEMEVN KREVIKAKKE SEEEHIYKKL NEELELTYAE
ALDICEPVEN EEDLKSNISS IKSKITKLGI VNLAAIEEYE ELKEKFEFMS NQAEDLEKAK
EELIRVIDEM TGEMRILFKE NFKILNHNFN ETFKDLFQGG SAELILGEGD ELSANIDINV
EPPGKKLQNI NLMSGGEKVL SAIALLFAIL KMKPTPFCIL DEIEAALDDA NVYRYAEFLL
RFSNRTQFIV ITHRKGTMEA SDIIYGVTME EKGISKVVSV DLSKDDE
//
