ID C4IMI4_CLOBU Unreviewed; 573 AA.
AC C4IMI4;
DT 07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 07-JUL-2009, sequence version 1.
DT 24-JAN-2024, entry version 33.
DE SubName: Full=Na+/H+ antiporter family protein {ECO:0000313|EMBL:EEP52506.1};
GN ORFNames=CLP_4249 {ECO:0000313|EMBL:EEP52506.1};
OS Clostridium butyricum E4 str. BoNT E BL5262.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=632245 {ECO:0000313|EMBL:EEP52506.1, ECO:0000313|Proteomes:UP000003081};
RN [1] {ECO:0000313|EMBL:EEP52506.1, ECO:0000313|Proteomes:UP000003081}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=E4 str. BoNT E BL5262 {ECO:0000313|Proteomes:UP000003081};
RA Shrivastava S., Brinkac L.B., Brown J.L., Bruce D.B., Detter C.,
RA Green L.D., Munk C.A., Rogers Y.C., Tapia R., Sims D.R., Smith L.A.,
RA Smith T.J., Sutton G., Brettin T.;
RL Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EEP52506.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; ACOM01000009; EEP52506.1; -; Genomic_DNA.
DR RefSeq; WP_003412172.1; NZ_ACOM01000009.1.
DR AlphaFoldDB; C4IMI4; -.
DR STRING; 1492.ATN24_01810; -.
DR GeneID; 66379896; -.
DR eggNOG; COG1757; Bacteria.
DR HOGENOM; CLU_018751_0_1_9; -.
DR Proteomes; UP000003081; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR InterPro; IPR018461; Na/H_Antiport_NhaC-like_C.
DR PANTHER; PTHR43478; NA+/H+ ANTIPORTER-RELATED; 1.
DR PANTHER; PTHR43478:SF1; NA_H_ANTIPORTER DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF03553; Na_H_antiporter; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000003081};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..573
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002938790"
FT TRANSMEM 36..56
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 63..86
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 106..123
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 187..208
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 236..254
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 299..319
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 358..376
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 396..414
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 434..456
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 476..493
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 523..540
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 546..565
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 197..534
FT /note="Na+/H+ antiporter NhaC-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03553"
SQ SEQUENCE 573 AA; 61144 MW; A28F134284532209 CRC64;
MKNFRKYYVF LLTLLVFMMP SIAAFASDDV AGDNAAKFGL LTILPPLVAI ALAFITKNVV
ISLFLGTVSG CFLLQISGNN IIYAIIHSFL DFVQRALNSL ADPWNAGIVL QVMVIGGVIS
LVSKMGGAKA IAEALAKRAK TPRSAQLITW LLGILVFFDD YANSLIVGPI MKPVADKMKI
SREKLSFIID ATAAPIAGIM IISTWIGLEV GLIKDGFESI GQSADAFGVF LNTIPYRFYN
ILILIFVVAT SYFLRDFGPM RKAEIKARKG QISETNKEIA LDKAAEDEMA PKEGVKLSIW
NAIIPIGALM ISALISFYYS GYTSIMGGED AALQAIMTNS PMSFTAIREA FSASDASVAL
FQSALFASIV AIAMGVGKKI FTFSEAVDVW VDGMKGLIIT GVILILAWSL SSVIKELGTA
AFLVQMLSNS VPKFLLPSII FILGAVISFA TGTAYGTMGI LMPLAIPLSY SISPDFGYVV
ISTSAVLTGA IFGDHCSPIS DTTIMSSMGA GCHHIDHVKT QMPYALTVAA ITVICGYIPA
GLGISVWIVL PIAAIVTCGV VYFVGKPVDN VEE
//
