ID   C4JF77_UNCRE            Unreviewed;       585 AA.
AC   C4JF77;
DT   07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   07-JUL-2009, sequence version 1.
DT   27-MAR-2024, entry version 63.
DE   RecName: Full=Cystathionine gamma-synthase {ECO:0008006|Google:ProtNLM};
GN   ORFNames=UREG_02299 {ECO:0000313|EMBL:EEP77450.1};
OS   Uncinocarpus reesii (strain UAMH 1704).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenaceae; Uncinocarpus.
OX   NCBI_TaxID=336963 {ECO:0000313|EMBL:EEP77450.1, ECO:0000313|Proteomes:UP000002058};
RN   [1] {ECO:0000313|Proteomes:UP000002058}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UAMH 1704 {ECO:0000313|Proteomes:UP000002058};
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000256|ARBA:ARBA00001933,
CC         ECO:0000256|RuleBase:RU362118};
CC   -!- SIMILARITY: Belongs to the trans-sulfuration enzymes family.
CC       {ECO:0000256|RuleBase:RU362118}.
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DR   EMBL; CH476615; EEP77450.1; -; Genomic_DNA.
DR   RefSeq; XP_002542783.1; XM_002542737.1.
DR   AlphaFoldDB; C4JF77; -.
DR   STRING; 336963.C4JF77; -.
DR   GeneID; 8441578; -.
DR   KEGG; ure:UREG_02299; -.
DR   VEuPathDB; FungiDB:UREG_02299; -.
DR   eggNOG; KOG0053; Eukaryota.
DR   HOGENOM; CLU_011302_1_0_1; -.
DR   InParanoid; C4JF77; -.
DR   OMA; CITETIG; -.
DR   OrthoDB; 35837at2759; -.
DR   Proteomes; UP000002058; Unassembled WGS sequence.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR   GO; GO:0019346; P:transsulfuration; IEA:InterPro.
DR   Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR   Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR   InterPro; IPR000277; Cys/Met-Metab_PyrdxlP-dep_enz.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR   PANTHER; PTHR42699; -; 1.
DR   PANTHER; PTHR42699:SF1; CYSTATHIONINE GAMMA-SYNTHASE-RELATED; 1.
DR   Pfam; PF01053; Cys_Met_Meta_PP; 1.
DR   SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE   3: Inferred from homology;
KW   Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898,
KW   ECO:0000256|RuleBase:RU362118};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002058}.
SQ   SEQUENCE   585 AA;  64633 MW;  004660188A231716 CRC64;
     MVNSELLPFP KSQSFPLGES LPPKDIHAVS VSIPTWDEIV RYMKGDEDIH QKLQADYPRH
     DTIHSVSEQW SNPCCRFYQH AIVSKLNDAV LARVGAAESV GCMIFPSEDG MRRCTEHLQK
     TADLAFPIRE VEFRLTQDVS RENVTWGHFF AVLFPEKSRE HAAGFWGFMG DGISSRHAEF
     CLERFPFMDS VSLDPSLQTA ATSNETERMP AVPWDHSDSG TKDKIKNLIA KWARSEKSSQ
     DPVRPQDVFL YPRGMCAIGS LARSLVPSST DASEAVVFGW PYGSTPKCVQ DSGYDRFTFH
     DQGTSEELDA LERSLASGRL ISCLFCELPS NPLCATPDLH RIRRLADQYS FVVICDETIG
     TFVNVDVIPY ADIVVTSLTK IFSGACNVMG GSVILNAQSP MYEELHAKLS SSHEDLIYPL
     DAKVLLRNCI DFPSRVQKAS CNGLAIANFL TTHKSISKVN YPTMVATAPL YERYRRPGGG
     YGSLISIVFR NPDSAVLFYN TIDLCKGPSF GTNFTLVLPY SQLAHAHQLD WAESKGLAKH
     LIRISVGLEE ESGLITKLGR ALEEVERFED GLASGASSGG AHGAA
//