ID   C4JGL5_UNCRE            Unreviewed;       512 AA.
AC   C4JGL5;
DT   07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   07-JUL-2009, sequence version 1.
DT   27-MAR-2024, entry version 63.
DE   RecName: Full=Aromatic-L-amino-acid decarboxylase {ECO:0008006|Google:ProtNLM};
GN   ORFNames=UREG_02527 {ECO:0000313|EMBL:EEP77678.1};
OS   Uncinocarpus reesii (strain UAMH 1704).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenaceae; Uncinocarpus.
OX   NCBI_TaxID=336963 {ECO:0000313|EMBL:EEP77678.1, ECO:0000313|Proteomes:UP000002058};
RN   [1] {ECO:0000313|Proteomes:UP000002058}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UAMH 1704 {ECO:0000313|Proteomes:UP000002058};
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000256|ARBA:ARBA00001933,
CC         ECO:0000256|PIRSR:PIRSR602129-50, ECO:0000256|RuleBase:RU000382};
CC   -!- SIMILARITY: Belongs to the group II decarboxylase family.
CC       {ECO:0000256|ARBA:ARBA00009533, ECO:0000256|RuleBase:RU000382}.
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DR   EMBL; CH476615; EEP77678.1; -; Genomic_DNA.
DR   RefSeq; XP_002543011.1; XM_002542965.1.
DR   AlphaFoldDB; C4JGL5; -.
DR   STRING; 336963.C4JGL5; -.
DR   GeneID; 8443215; -.
DR   KEGG; ure:UREG_02527; -.
DR   VEuPathDB; FungiDB:UREG_02527; -.
DR   eggNOG; KOG0628; Eukaryota.
DR   HOGENOM; CLU_011856_3_1_1; -.
DR   InParanoid; C4JGL5; -.
DR   OMA; NPGFNWS; -.
DR   OrthoDB; 47798at2759; -.
DR   Proteomes; UP000002058; Unassembled WGS sequence.
DR   GO; GO:0016831; F:carboxy-lyase activity; IEA:InterPro.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR   GO; GO:0006520; P:amino acid metabolic process; IEA:InterPro.
DR   Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR   Gene3D; 1.20.1340.10; dopa decarboxylase, N-terminal domain; 1.
DR   Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR   InterPro; IPR010977; Aromatic_deC.
DR   InterPro; IPR002129; PyrdxlP-dep_de-COase.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR   InterPro; IPR021115; Pyridoxal-P_BS.
DR   PANTHER; PTHR11999:SF70; AROMATIC-L-AMINO-ACID DECARBOXYLASE; 1.
DR   PANTHER; PTHR11999; GROUP II PYRIDOXAL-5-PHOSPHATE DECARBOXYLASE; 1.
DR   Pfam; PF00282; Pyridoxal_deC; 1.
DR   PRINTS; PR00800; YHDCRBOXLASE.
DR   SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR   PROSITE; PS00392; DDC_GAD_HDC_YDC; 1.
PE   3: Inferred from homology;
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000382};
KW   Pyridoxal phosphate {ECO:0000256|PIRSR:PIRSR602129-50,
KW   ECO:0000256|RuleBase:RU000382};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002058}.
FT   MOD_RES         318
FT                   /note="N6-(pyridoxal phosphate)lysine"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR602129-50"
SQ   SEQUENCE   512 AA;  56698 MW;  CAE47871EDE7E312 CRC64;
     MDADQFRQAA QSAIEEIIEH FNTLPSRRVL PNIEPGYLRP LLPQSPPKSP ESWDQIQQDI
     ESKIKPGLTH WQSPHFMAFF PALTTYPSIL AEIYSAAFSA PAFNWLCSPA CTELEIVVLD
     WVAQAIGLPE CFHSTGPTRG GGVIQGSASE AVVTVMVAAR ERMLRDLATA EGLKEDTPEW
     EDRVMVLRGK LVAIGSDQAH SCTAKGARIV GTRYRTVPTA LEDNFDMTGE SVRKVLEECE
     AAGLIPYYIT TTMGTTSTCA TDRFAEIKAV LASRPSWQKI WVHIDAAYAG AALITPEYQP
     IAREWSTGID SFNFNMHKWL LVNFDASCLF VRNRTDLTSA MDITPAYLRN PYSDRPDTVD
     FRNWQIPLGR RFRALKIWFV MRAYGLSGMK AFIYKGLHHG DVFVELFGGR KDLFTVVTPP
     AFGLTVFRIS DEAAAAAGSA SGALTRQVYE KINADGDIFI TSSVVGGIYV MRVLSGSWLS
     EEKYVRNAFE IILKTTEEVL SGKPNGAEGP KN
//