ID   C4JJ28_UNCRE            Unreviewed;       796 AA.
AC   C4JJ28;
DT   07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   07-JUL-2009, sequence version 1.
DT   27-MAR-2024, entry version 64.
DE   RecName: Full=Hexokinase {ECO:0008006|Google:ProtNLM};
GN   ORFNames=UREG_01635 {ECO:0000313|EMBL:EEP76786.1};
OS   Uncinocarpus reesii (strain UAMH 1704).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenaceae; Uncinocarpus.
OX   NCBI_TaxID=336963 {ECO:0000313|EMBL:EEP76786.1, ECO:0000313|Proteomes:UP000002058};
RN   [1] {ECO:0000313|Proteomes:UP000002058}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UAMH 1704 {ECO:0000313|Proteomes:UP000002058};
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
CC   -!- SIMILARITY: Belongs to the hexokinase family.
CC       {ECO:0000256|ARBA:ARBA00009225}.
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DR   EMBL; CH476615; EEP76786.1; -; Genomic_DNA.
DR   RefSeq; XP_002542119.1; XM_002542073.1.
DR   AlphaFoldDB; C4JJ28; -.
DR   STRING; 336963.C4JJ28; -.
DR   GeneID; 8438604; -.
DR   KEGG; ure:UREG_01635; -.
DR   VEuPathDB; FungiDB:UREG_01635; -.
DR   eggNOG; KOG1369; Eukaryota.
DR   HOGENOM; CLU_014393_4_1_1; -.
DR   InParanoid; C4JJ28; -.
DR   OrthoDB; 5481886at2759; -.
DR   UniPathway; UPA00109; UER00180.
DR   Proteomes; UP000002058; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0005536; F:glucose binding; IEA:InterPro.
DR   GO; GO:0004396; F:hexokinase activity; IEA:InterPro.
DR   GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0001678; P:intracellular glucose homeostasis; IEA:InterPro.
DR   CDD; cd00012; NBD_sugar-kinase_HSP70_actin; 1.
DR   Gene3D; 3.30.420.40; -; 1.
DR   Gene3D; 3.40.367.20; -; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR001312; Hexokinase.
DR   InterPro; IPR022673; Hexokinase_C.
DR   InterPro; IPR022672; Hexokinase_N.
DR   PANTHER; PTHR19443; HEXOKINASE; 1.
DR   PANTHER; PTHR19443:SF24; HEXOKINASE YLR446W-RELATED; 1.
DR   Pfam; PF00349; Hexokinase_1; 1.
DR   Pfam; PF03727; Hexokinase_2; 1.
DR   PRINTS; PR00475; HEXOKINASE.
DR   SUPFAM; SSF53067; Actin-like ATPase domain; 2.
DR   PROSITE; PS51748; HEXOKINASE_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Kinase {ECO:0000256|ARBA:ARBA00022777};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002058};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          308..488
FT                   /note="Hexokinase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00349"
FT   DOMAIN          495..790
FT                   /note="Hexokinase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03727"
SQ   SEQUENCE   796 AA;  87771 MW;  FF5A658AD4F93793 CRC64;
     MSSSKGYLPA KAWMIVDSAA CLELEAWGQD GGLDSTYRPR AFGVESAIIV IEACHQLRGT
     LCIKHSTSLR ELSRLLCVKY KRSQEWYPEL KRYAPKRACH TLITGCCAGC LVCQFGPFAV
     YGQYSAFTAP RTASFQHHRC LAVSTSNVTL PRREHSNVVK KANDDGCCSA LSSPTPKSPS
     ARLRSKFTAL DTTLFLALHF ALGDSSHSFP RKDIVDSDVS LFTRIRQILN RNLATVVMGD
     SLVKAAHQLQ KFFSHLVQII HKLLNGSFRG EATGKRRRFN KRRRSLKDFA QEVEQLFIGH
     LSTGRLASMS KEIRSQLRSS AQSSHINMLP SFSHSLPSGN EKGTYLALDV GGSTLRVALV
     ELLGKNGEMK ILRIASSHIN EDVKALMGKA FFDWMAGKIE EMLQNGTEDH GKDSSPLPMG
     LSWSFPIEQT SIRSGNVIAM GKGFRCSDGT VGDDLRELIM EACQKRNLNV TLEAIVNDGS
     ATLLSRAYVD PTTRLSLILG TGTNMSVHFP VHAIGIEKYG KRSPEWFAQA DHVITNTEIS
     MFGGGVLQMT RWDDDLNRNH IKPDYQPLEY MCTGRYLGEI VRLIAVEAVQ TAGLFGGHLP
     ASMQARYSLD TADIACIEED TSPSFKQSLD LIQEHHQFRI PPTPADIAFL KTISHCVSQR
     ATAYLAVAIH GLWCLRNESE TPILPATPES MNDDSNVKPH RKEYPKDPVR LQVNIACDGS
     VINKYPNFRT RCQNYLNQLT LEPDPPQSIS PTDDVVVMKE PTSSVDQLPS ITLDSAPESG
     IFGAAVAVAV AAPGNE
//