ID C4JKS4_UNCRE Unreviewed; 412 AA.
AC C4JKS4;
DT 07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 07-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE RecName: Full=methylmalonate-semialdehyde dehydrogenase (CoA acylating) {ECO:0000256|ARBA:ARBA00013048};
DE EC=1.2.1.27 {ECO:0000256|ARBA:ARBA00013048};
GN ORFNames=UREG_00620 {ECO:0000313|EMBL:EEP75773.1};
OS Uncinocarpus reesii (strain UAMH 1704).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Uncinocarpus.
OX NCBI_TaxID=336963 {ECO:0000313|EMBL:EEP75773.1, ECO:0000313|Proteomes:UP000002058};
RN [1] {ECO:0000313|Proteomes:UP000002058}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UAMH 1704 {ECO:0000313|Proteomes:UP000002058};
RX PubMed=19717792; DOI=10.1101/gr.087551.108;
RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA Henn M.R., Birren B.W., Taylor J.W.;
RT "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT and their relatives.";
RL Genome Res. 19:1722-1731(2009).
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DR EMBL; CH476615; EEP75773.1; -; Genomic_DNA.
DR RefSeq; XP_002541106.1; XM_002541060.1.
DR AlphaFoldDB; C4JKS4; -.
DR STRING; 336963.C4JKS4; -.
DR GeneID; 8438641; -.
DR KEGG; ure:UREG_00620; -.
DR VEuPathDB; FungiDB:UREG_00620; -.
DR eggNOG; KOG2449; Eukaryota.
DR HOGENOM; CLU_005391_1_10_1; -.
DR InParanoid; C4JKS4; -.
DR OMA; VEYATYV; -.
DR OrthoDB; 275238at2759; -.
DR Proteomes; UP000002058; Unassembled WGS sequence.
DR GO; GO:0004491; F:methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity; IEA:UniProtKB-EC.
DR InterPro; IPR016161; Ald_DH/histidinol_DH.
DR InterPro; IPR016163; Ald_DH_C.
DR InterPro; IPR016160; Ald_DH_CS_CYS.
DR InterPro; IPR016162; Ald_DH_N.
DR InterPro; IPR015590; Aldehyde_DH_dom.
DR InterPro; IPR010061; MeMal-semiAld_DH.
DR NCBIfam; TIGR01722; MMSDH; 1.
DR PANTHER; PTHR43866; MALONATE-SEMIALDEHYDE DEHYDROGENASE; 1.
DR PANTHER; PTHR43866:SF3; METHYLMALONATE-SEMIALDEHYDE DEHYDROGENASE [ACYLATING], MITOCHONDRIAL; 1.
DR Pfam; PF00171; Aldedh; 1.
DR SUPFAM; SSF53720; ALDH-like; 1.
DR PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002058}.
FT DOMAIN 3..330
FT /note="Aldehyde dehydrogenase"
FT /evidence="ECO:0000259|Pfam:PF00171"
FT REGION 331..371
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 332..350
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 412 AA; 44056 MW; 00B2164A14F9858A CRC64;
MAKQQIMFKY VNVIRANWDR LAASITLEQG KTFADAKGDV LRGLQVAETA CGITTQMTGE
LLEVAKDMET RTYREPLGVV AAICPFNFPA MIPLWSIPIA TMTGNTLILK PSERDPGAAM
ILVELAKEAG FPEGVINVIH GAAKTVDFIL DEPAIKAISF VGSNRAGEYI YTRGSANGKR
VQANLGAKNH AAVLPDCNKN HSLNAIVGAA FGAAGQRCMA LSTLVMVGET KEWLPEIAER
AKGLSVNGGF EEGADLGPVI TPQSKKRIEE LIASAEEEGA TILLDGRGYT PPKYPNGNWV
GPTIITGVKP HMKCYREEIF GPVLVCLEVE PSTKPSPSST PTNTETALPS SPAPVPLPPA
SSTSSRPASS VSRSLSPMFL LHRLTRRSIA ADSANTFYGK PRVELLYPSS RP
//
