ID   C4JLP4_UNCRE            Unreviewed;      1046 AA.
AC   C4JLP4;
DT   07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   07-JUL-2009, sequence version 1.
DT   27-MAR-2024, entry version 58.
DE   RecName: Full=Helicase required for RNAi-mediated heterochromatin assembly 1 {ECO:0008006|Google:ProtNLM};
GN   ORFNames=UREG_03752 {ECO:0000313|EMBL:EEP78906.1};
OS   Uncinocarpus reesii (strain UAMH 1704).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenaceae; Uncinocarpus.
OX   NCBI_TaxID=336963 {ECO:0000313|EMBL:EEP78906.1, ECO:0000313|Proteomes:UP000002058};
RN   [1] {ECO:0000313|Proteomes:UP000002058}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UAMH 1704 {ECO:0000313|Proteomes:UP000002058};
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
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DR   EMBL; CH476616; EEP78906.1; -; Genomic_DNA.
DR   RefSeq; XP_002544235.1; XM_002544189.1.
DR   AlphaFoldDB; C4JLP4; -.
DR   GeneID; 8444128; -.
DR   KEGG; ure:UREG_03752; -.
DR   VEuPathDB; FungiDB:UREG_03752; -.
DR   eggNOG; KOG1807; Eukaryota.
DR   HOGENOM; CLU_001066_2_0_1; -.
DR   InParanoid; C4JLP4; -.
DR   OMA; EWIMVEA; -.
DR   OrthoDB; 7041at2759; -.
DR   Proteomes; UP000002058; Unassembled WGS sequence.
DR   GO; GO:0004386; F:helicase activity; IEA:InterPro.
DR   CDD; cd18808; SF1_C_Upf1; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR045055; DNA2/NAM7-like.
DR   InterPro; IPR041679; DNA2/NAM7-like_C.
DR   InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR047187; SF1_C_Upf1.
DR   PANTHER; PTHR10887; DNA2/NAM7 HELICASE FAMILY; 1.
DR   PANTHER; PTHR10887:SF341; NFX1-TYPE ZINC FINGER-CONTAINING PROTEIN 1; 1.
DR   Pfam; PF13086; AAA_11; 1.
DR   Pfam; PF13087; AAA_12; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000002058}.
FT   DOMAIN          300..646
FT                   /note="DNA2/NAM7 helicase helicase"
FT                   /evidence="ECO:0000259|Pfam:PF13086"
FT   DOMAIN          662..845
FT                   /note="DNA2/NAM7 helicase-like C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13087"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1046 AA;  117417 MW;  EB7D87C502EC15C7 CRC64;
     MAPRYFGRLP GKAPASAPPT PAPLNRSIRE YVKAANAVAK PGSWTAKPEV PSSNEILGID
     DGINPGDAVY LMPNQIDGPW ESRDTYLKAH YELLREDAIA PLRDAVAYVR QDPRMLDTLD
     VCIYEKVHIV GITCAQAGIA VRVQFSTARA GKNIVWEYSQ RLTTGKIVAL TPTNDGFKRR
     CVVAVVAARP LEALKSHPCE IDLFFANPDD AEFDYQQEWL MVESRNGYYE AVRHTLMALQ
     KMSTESFPLS EYICDLSHNV APPEYVKRDS IIDMAELYCH SDGPSRVNVL EDWPSPPESL
     DGSQWKALRQ ILTKRLSIVQ GPPGTGKTHV SVVAIKTLLS NMARKDPPII IAAQTNHALD
     QLLRHVATFE QNYVRLGGRS TDLEIRKRTV FELRKKYSIP FVVGGALNPA RKHHKQLTNR
     LVELMEPFIL ERSSLPLPAT LFLKLGIITQ TQHDSLIKGS EGWICSGDEM DPVSSWLGEG
     RIKYDVTYKM ENFGFVEDEI DLEYEQLKEL EAEQGLDDDD YESLRGQYMA LKEGYLGRMN
     PMITEKAVNA QYLKCDDMWK IPASARGLAT NLKVGKWERD SIILRDARII GMTTTGLSKY
     RALVSSIKPK IILVEEAAEV LEAPVAAACV ESLEHLILVG DHKQLQGQCS LKELEGEPFY
     LNISMFERLV HNGVEFKCLT KQRRMAPEIR RMLAPIYHNL EDHEAVLNRP GIPGMGNLSS
     YFFCHAWPES SDSLLSKYNE NEAKMVVGFY LYLFMNGVSA EHITVLTFYN GQRKKILKAL
     KDAPLLQGQY AKVVTVDSYQ GEENEVVLLS LVRSGEHNIG FLSVENRVCV ALSRAKRGFY
     IFGNAEALSI RNGLWWEVVQ IMRKEPKRPR DVEEAGWGVS IPLFTHERVR CGRPCRQLLP
     CGHECKKKCF LSCECDCDIA QKAATIQKAA QYPENIAADM HIKQLASVQR YRDFANGGAK
     EADAQLVRQT KQLAIEEGLK LADEQAYESL FGAEETDPTP AEHSVVERVP NINGPSRYRY
     TQYYSSAPAK VSTGGPKQSE PSLLDL
//