ID C4JN45_UNCRE Unreviewed; 1239 AA.
AC C4JN45;
DT 07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 07-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=VASt domain-containing protein {ECO:0000259|PROSITE:PS51778};
GN ORFNames=UREG_04253 {ECO:0000313|EMBL:EEP79407.1};
OS Uncinocarpus reesii (strain UAMH 1704).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Uncinocarpus.
OX NCBI_TaxID=336963 {ECO:0000313|EMBL:EEP79407.1, ECO:0000313|Proteomes:UP000002058};
RN [1] {ECO:0000313|Proteomes:UP000002058}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UAMH 1704 {ECO:0000313|Proteomes:UP000002058};
RX PubMed=19717792; DOI=10.1101/gr.087551.108;
RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA Henn M.R., Birren B.W., Taylor J.W.;
RT "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT and their relatives.";
RL Genome Res. 19:1722-1731(2009).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the YSP2 family.
CC {ECO:0000256|ARBA:ARBA00006582}.
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DR EMBL; CH476616; EEP79407.1; -; Genomic_DNA.
DR RefSeq; XP_002544736.1; XM_002544690.1.
DR AlphaFoldDB; C4JN45; -.
DR STRING; 336963.C4JN45; -.
DR GeneID; 8437102; -.
DR KEGG; ure:UREG_04253; -.
DR VEuPathDB; FungiDB:UREG_04253; -.
DR eggNOG; KOG1032; Eukaryota.
DR HOGENOM; CLU_006864_0_0_1; -.
DR InParanoid; C4JN45; -.
DR OMA; PSGNMIS; -.
DR OrthoDB; 45896at2759; -.
DR Proteomes; UP000002058; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0043226; C:organelle; IEA:UniProt.
DR CDD; cd13220; PH-GRAM_GRAMDC; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR004182; GRAM.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR031968; VASt.
DR PANTHER; PTHR23319:SF4; AT22714P-RELATED; 1.
DR PANTHER; PTHR23319; UNCHARACTERIZED; 1.
DR Pfam; PF02893; GRAM; 1.
DR Pfam; PF16016; VASt; 1.
DR SMART; SM00568; GRAM; 1.
DR PROSITE; PS51778; VAST; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00022989};
KW Reference proteome {ECO:0000313|Proteomes:UP000002058};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 866..1038
FT /note="VASt"
FT /evidence="ECO:0000259|PROSITE:PS51778"
FT REGION 1..375
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 402..445
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 467..499
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 515..590
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 742..802
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 817..864
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 32..61
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 85..109
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 110..135
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 136..155
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 200..223
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 270..301
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 312..339
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 347..365
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 426..441
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 523..537
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 763..785
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1239 AA; 134135 MW; 9264F18D1037C2DC CRC64;
MENNASESPS AASPNGLKIF PGPKRSRTAL NEADHSYPSD QSSRTPSLDI RPATSHGSNA
APTGLAKLIP GAKRRHRKKA KALNSDGLAN SSENLGESRV SLPTLEVNEQ RRRSMTDPGS
NHGTDDSESE SNHDNEWGRS PLITISNPSI DERSQSAHDS ALDKLNILRS STIGAPAHDP
SAKESMGSAA GRKLRDAFNP RSSNRSSNSS PDRESTKSSG SKGGKGFLDS AVRKTSFSSK
KSKKGLEDIP LILPPPKFPD GDTPKPHRQL PPIDTTPKTP PSIARPPPVT TTVTPPTPTH
PKPRDFDTRM VDSPESMTSS SKLPENAVLS PSGNMISHRR VRSASAAHNP SKLSNSITVP
PTPIDENKVS ASRHAPSNLV GGGFFSTMFS AAQNAASTLS IGLNQGRTRN GTDSVDTEQH
MKPSPAENES ESSSSQDNTL EQKKELAIDT MGTGDLDFSH LGIDASAGGV VTTPDGVVFT
KSDYVGPSRR STVSQRDELA SRIEDLRAAR AVSMAYERPP QSAGLPGSTN ENQPPDGRPS
APFSGFGRSS GGERTPPTAS IAEGDIAQHV KRSGSLHSRR GIRRKRGSST ATATTIGAIG
AALGVPGINL SVPRLTGFAV ASKKRNRDFH QLFRSVPEDD YLIEDYSCAL QREIILAGRI
YISEGHICFS SNILGWVTTL VIGFDEIVAI EKESTAMVFP NAIAIQTLHA RHTFRSLLSR
DSTYDLMVNI WKINHPTLKS SVNGAQIEQG TGDKTEKAEL SDDEDVSMSD DEEEVYDEDE
EGGAGSNAEA ADSTVASDLS ESGKRFIRKS STMPVSATAS SQAISVGAAD ESKGLDKSKG
LPDGTAQFPG PRSHAPTEFT DPSGRYDKVV KDEVIPAPLG QVYSLIFGAA SSSFVSKFLV
EYEKVTDLQF EEDKTGLTEE NKTRSYTYIK PLNSTIGPKQ TKCITVEQLD VLDLEKAVLV
TLTTQTPDVP SGNVFSVKTK YLLTWAPGNS TRFFMSCNVE WTGKSWIKGP IEKGANDGQL
GYGSNLIKAV KAGIAPKTRK VTSKGAVKGK IRRAKTVISE TGSNDGESSK SVRDKAASWG
LLEPLRGPLS PITDIFSPFW SPNVAIVVLC SLLFMTWFRS WEDIGRGTVA PRTRSRGIPL
HHLSIPERLL AYDELWAKEE SELWDWLEDR VGMENLVIPV ADTDRSYSKQ AHRDAENRLR
DERMSEREIA DAIRVTQQRL ETLQQVVERR KSNRRQTKK
//
