ID C4JPG5_UNCRE Unreviewed; 1341 AA.
AC C4JPG5;
DT 07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 07-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 78.
DE RecName: Full=Elongator complex protein 2 {ECO:0000256|ARBA:ARBA00020267};
GN ORFNames=UREG_03136 {ECO:0000313|EMBL:EEP78291.1};
OS Uncinocarpus reesii (strain UAMH 1704).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Uncinocarpus.
OX NCBI_TaxID=336963 {ECO:0000313|EMBL:EEP78291.1, ECO:0000313|Proteomes:UP000002058};
RN [1] {ECO:0000313|Proteomes:UP000002058}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UAMH 1704 {ECO:0000313|Proteomes:UP000002058};
RX PubMed=19717792; DOI=10.1101/gr.087551.108;
RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA Henn M.R., Birren B.W., Taylor J.W.;
RT "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT and their relatives.";
RL Genome Res. 19:1722-1731(2009).
CC -!- PATHWAY: tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA
CC biosynthesis. {ECO:0000256|ARBA:ARBA00005043}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the WD repeat ELP2 family.
CC {ECO:0000256|ARBA:ARBA00005881}.
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DR EMBL; CH476616; EEP78291.1; -; Genomic_DNA.
DR RefSeq; XP_002543620.1; XM_002543574.1.
DR STRING; 336963.C4JPG5; -.
DR GeneID; 8437768; -.
DR KEGG; ure:UREG_03136; -.
DR VEuPathDB; FungiDB:UREG_03136; -.
DR eggNOG; KOG0234; Eukaryota.
DR eggNOG; KOG1063; Eukaryota.
DR HOGENOM; CLU_004787_0_0_1; -.
DR InParanoid; C4JPG5; -.
DR OMA; QKVGWLC; -.
DR OrthoDB; 22040at2759; -.
DR UniPathway; UPA00988; -.
DR Proteomes; UP000002058; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0033588; C:elongator holoenzyme complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003873; F:6-phosphofructo-2-kinase activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0006003; P:fructose 2,6-bisphosphate metabolic process; IEA:InterPro.
DR GO; GO:0006000; P:fructose metabolic process; IEA:InterPro.
DR GO; GO:0002098; P:tRNA wobble uridine modification; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.40.50.1240; Phosphoglycerate mutase-like; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 5.
DR InterPro; IPR003094; 6Pfruct_kin.
DR InterPro; IPR013079; 6Phosfructo_kin.
DR InterPro; IPR037289; Elp2.
DR InterPro; IPR013078; His_Pase_superF_clade-1.
DR InterPro; IPR029033; His_PPase_superfam.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR44111; ELONGATOR COMPLEX PROTEIN 2; 1.
DR PANTHER; PTHR44111:SF1; ELONGATOR COMPLEX PROTEIN 2; 1.
DR Pfam; PF01591; 6PF2K; 1.
DR Pfam; PF00300; His_Phos_1; 1.
DR Pfam; PF00400; WD40; 6.
DR PRINTS; PR00991; 6PFRUCTKNASE.
DR SMART; SM00855; PGAM; 1.
DR SMART; SM00320; WD40; 11.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF53254; Phosphoglycerate mutase-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 6.
DR PROSITE; PS50294; WD_REPEATS_REGION; 3.
PE 3: Inferred from homology;
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000002058};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW tRNA processing {ECO:0000256|ARBA:ARBA00022694};
KW WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT DOMAIN 45..281
FT /note="6-phosphofructo-2-kinase"
FT /evidence="ECO:0000259|Pfam:PF01591"
FT REPEAT 619..656
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 739..786
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 825..859
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 931..961
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1147..1179
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1195..1229
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 531..563
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 537..554
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1341 AA; 148995 MW; EFCC054ACBDA0DAD CRC64;
MDTYLNADVV ANSPRFRRKS STFVDAIHDL RDKPEIAPAQ LYSTESGRLF HSGRIVIITV
GLPARGKTSQ DICAGSALKL AYSILGIIDV RPLALDKTCR RTISSSKASV SFNVILIGHL
SGSIDILPKP SASSVLMRQK IVKKCRDDIY HFLSDDNGQV AIYDAVNPIA AGRRSLAKEF
GKYGIETLFI ESWCDDEKII EENVQRVKIS SPDYKGWDPK DAVKDYLARI SARIPQFQTM
EEKDLNYIKM INAGDKMMIN NCSFGYLHHR IVFYLLNLHI QNRRTYFARA GTSLEADSYK
ADASLSPQGE DYARKMTQRL LEYREEERQA AKEQGDLDAI TRPLIVWTST RRRTTETAQF
LHKKGFKTRH RSQLSQLNPG VCEKMSERRI REEFPDEVAQ HDLDPYHHRY PRAESYHDLA
VRLEPIILEL ERERNDLLII AHESVLRVLY GYLMACNAAD IPFLSFPRDE IIEVIFRNID
FFCDNRELIR VQNVQIIPGS YSNEAKRIHV PDLPPEIIPG SPEDIKIPVP PSGAVSPMPD
GSSSALTRGG TPQSGFRTPR DPERISQLHV EDVVNEVLEK MDILHRVIQH EQLPPFIFHD
VLTEVLDEDP NRRGVYALLV GHTDTVNAVK FYTPPSGNPS RHLLITGSVD RTIRIWAPNG
STPLSFTLAT TLQGHDNSIN CIAVAEKSDV FVSRAADGLT LVIPVEALVL ALGGTRSIVQ
VYVAQDSSKE VHFELKATLT GHEGWIRSLA FTAVEFPGTQ DFLLASASQD KYIRLWRVHP
GKSAISAAPQ NAEDAILGGM QALSNKAHTF ESDGAVYSIT FEALLFGHED WIYSIAWNPN
PEKLQLMSSS ADNSLVIWES DPVSGAWYSG SRMGEISVQK GSTTATGSAG GFWVGLWAPD
GDVVISLGRT GSWRSWRYES DADAWVQIMG ITGHVRSVND IVWEPSGGYL LSTSADQTTR
LHAKWSRDGH DSWHEFSRPQ IHGYDLNCIT SLGPTRFVSG ADEKLLRVFN ETKSIAQLLE
RLSGFAQSSQ EEMAEAANIP VLGLSNKAMD DADVEEGDEN ETNGMQGGVP SQAIPLDLDH
PPLEDHLAKY TLWPEHEKLY GHGYEISAVA ASNNRSVIAT ACKASSIDHA VIRLYDTQSW
REIRPPLAAH TLTITALKFS PDDQYLLSVG RDRQWAVFER DAANKSLYQL LTSNLKAHSR
MILSASWAPH PTTKVFATAG RDKSVKLWSQ EGGTFVCKSN IAIGHPVTAI DFLPTVVDDK
FCLAVGDDSG AISVHVIAME NLMPGNSVAI PKFESPSKSI TQVLWRPSST FSRGDVIAKY
QLAVASDDSS VRIYNIDGVP S
//
