ID C4JQG5_UNCRE Unreviewed; 777 AA.
AC C4JQG5;
DT 07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 07-JUL-2009, sequence version 1.
DT 24-JAN-2024, entry version 78.
DE RecName: Full=Double-strand break repair protein {ECO:0000256|PIRNR:PIRNR000882};
GN ORFNames=UREG_04719 {ECO:0000313|EMBL:EEP79873.1};
OS Uncinocarpus reesii (strain UAMH 1704).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Uncinocarpus.
OX NCBI_TaxID=336963 {ECO:0000313|EMBL:EEP79873.1, ECO:0000313|Proteomes:UP000002058};
RN [1] {ECO:0000313|Proteomes:UP000002058}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UAMH 1704 {ECO:0000313|Proteomes:UP000002058};
RX PubMed=19717792; DOI=10.1101/gr.087551.108;
RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA Henn M.R., Birren B.W., Taylor J.W.;
RT "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT and their relatives.";
RL Genome Res. 19:1722-1731(2009).
CC -!- FUNCTION: Involved in DNA double-strand break repair (DSBR). Possesses
CC single-strand endonuclease activity and double-strand-specific 3'-5'
CC exonuclease activity. Also involved in meiotic DSB processing.
CC {ECO:0000256|PIRNR:PIRNR000882}.
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|PIRNR:PIRNR000882};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PIRNR:PIRNR000882}.
CC -!- SIMILARITY: Belongs to the MRE11/RAD32 family.
CC {ECO:0000256|ARBA:ARBA00009028, ECO:0000256|PIRNR:PIRNR000882,
CC ECO:0000256|RuleBase:RU003447}.
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DR EMBL; CH476616; EEP79873.1; -; Genomic_DNA.
DR RefSeq; XP_002545202.1; XM_002545156.1.
DR AlphaFoldDB; C4JQG5; -.
DR STRING; 336963.C4JQG5; -.
DR GeneID; 8441355; -.
DR KEGG; ure:UREG_04719; -.
DR VEuPathDB; FungiDB:UREG_04719; -.
DR eggNOG; KOG2310; Eukaryota.
DR HOGENOM; CLU_009535_1_1_1; -.
DR InParanoid; C4JQG5; -.
DR OMA; NHLGYGE; -.
DR OrthoDB; 169704at2759; -.
DR Proteomes; UP000002058; Unassembled WGS sequence.
DR GO; GO:0030870; C:Mre11 complex; IEA:UniProtKB-UniRule.
DR GO; GO:0008296; F:3'-5'-DNA exonuclease activity; IEA:InterPro.
DR GO; GO:0004520; F:DNA endonuclease activity; IEA:InterPro.
DR GO; GO:0030145; F:manganese ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006302; P:double-strand break repair; IEA:UniProtKB-UniRule.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR CDD; cd00840; MPP_Mre11_N; 1.
DR Gene3D; 3.60.21.10; -; 1.
DR Gene3D; 3.30.110.110; Mre11, capping domain; 1.
DR InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR InterPro; IPR029052; Metallo-depent_PP-like.
DR InterPro; IPR003701; Mre11.
DR InterPro; IPR038487; Mre11_capping_dom.
DR InterPro; IPR007281; Mre11_DNA-bd.
DR InterPro; IPR041796; Mre11_N.
DR NCBIfam; TIGR00583; mre11; 1.
DR PANTHER; PTHR10139; DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11; 1.
DR PANTHER; PTHR10139:SF1; DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11; 1.
DR Pfam; PF00149; Metallophos; 1.
DR Pfam; PF04152; Mre11_DNA_bind; 1.
DR PIRSF; PIRSF000882; DSB_repair_MRE11; 1.
DR SMART; SM01347; Mre11_DNA_bind; 1.
DR SUPFAM; SSF56300; Metallo-dependent phosphatases; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|PIRNR:PIRNR000882};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|PIRNR:PIRNR000882};
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759,
KW ECO:0000256|PIRNR:PIRNR000882};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839, ECO:0000256|PIRNR:PIRNR000882};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PIRNR:PIRNR000882};
KW Manganese {ECO:0000256|ARBA:ARBA00023211, ECO:0000256|PIRNR:PIRNR000882};
KW Meiosis {ECO:0000256|ARBA:ARBA00023254, ECO:0000256|PIRNR:PIRNR000882};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722, ECO:0000256|PIRNR:PIRNR000882};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR000882};
KW Reference proteome {ECO:0000313|Proteomes:UP000002058}.
FT DOMAIN 289..466
FT /note="Mre11 DNA-binding"
FT /evidence="ECO:0000259|SMART:SM01347"
FT REGION 526..777
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 619..648
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 663..750
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 124
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000882-1"
SQ SEQUENCE 777 AA; 87056 MW; 6865DB9EE529CE48 CRC64;
MSLGEADTIR ILVSTDNHVG YNERDPIRGD DSWTTFHEVM CLAKERDVDM VLLAGDLFHE
NKPSRKSMYQ VMRSLRMNCY GDKPCELEIL SDASENFQGA FNHVNYEDLD INVAIPVFSI
HGNHDDPSGE GHLAALDILQ VSGLLNYYGR TPESDNVQVK PVLLQKGRTK LALYGLSNVR
DERLFRTFRD GKVKFFRPSM QQSDWFNLLS VHQNHHSRTE TGYLPETFLP DFMDMVIWGH
EHECLIEPRL NPETNFHVIQ PGSSVATSLV AGEAVTKHVT ILSITGREFK SEPIRLKTVR
PFVMKDIVLY EEKEAQKLAR KENNRTEVTR FLMTLVDELI EEAKNDWLES QDGFNGEDSE
IPLPLVRLRV DTSIPEGGSF DCENPQRFSN RFVGKVANVN DVIQFHRKKK ATTLTRGDAN
APDETVVSHL ASLDTVKVER LVREFLTAQS LTILPQNSFG DAVSQFIDKD DKHAMEMFLN
ESLESQIKHL MNLDRDAEEG SDYDEEGARQ TLQAAMDQYR GQLEELFSKG KGKRKGGKRR
FKPRPDGWES EFDGAWEDQP GALIHSDNEG DPNAEEEEDE VPATNRRRGT AATATRGARG
GRARGTASSR GKIATTSTRG RGRGRDRQVV SEDDEDNADD RQQEHVMLNE DDEDIDMDDD
SLFVRQPSTT KSRATATAPS SRARKTTTTA ASARNPPARS TAATRGKQSQ ATLNFSRGSQ
PSQSQTIAGT SSTSGAGRRP TRSAASKTNI VISDIEDDED DDAFEPIPAS STRSRRR
//