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Database: UniProt
Entry: C4JQG5_UNCRE
LinkDB: C4JQG5_UNCRE
Original site: C4JQG5_UNCRE 
ID   C4JQG5_UNCRE            Unreviewed;       777 AA.
AC   C4JQG5;
DT   07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   07-JUL-2009, sequence version 1.
DT   24-JAN-2024, entry version 78.
DE   RecName: Full=Double-strand break repair protein {ECO:0000256|PIRNR:PIRNR000882};
GN   ORFNames=UREG_04719 {ECO:0000313|EMBL:EEP79873.1};
OS   Uncinocarpus reesii (strain UAMH 1704).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenaceae; Uncinocarpus.
OX   NCBI_TaxID=336963 {ECO:0000313|EMBL:EEP79873.1, ECO:0000313|Proteomes:UP000002058};
RN   [1] {ECO:0000313|Proteomes:UP000002058}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UAMH 1704 {ECO:0000313|Proteomes:UP000002058};
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
CC   -!- FUNCTION: Involved in DNA double-strand break repair (DSBR). Possesses
CC       single-strand endonuclease activity and double-strand-specific 3'-5'
CC       exonuclease activity. Also involved in meiotic DSB processing.
CC       {ECO:0000256|PIRNR:PIRNR000882}.
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|PIRNR:PIRNR000882};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|PIRNR:PIRNR000882}.
CC   -!- SIMILARITY: Belongs to the MRE11/RAD32 family.
CC       {ECO:0000256|ARBA:ARBA00009028, ECO:0000256|PIRNR:PIRNR000882,
CC       ECO:0000256|RuleBase:RU003447}.
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DR   EMBL; CH476616; EEP79873.1; -; Genomic_DNA.
DR   RefSeq; XP_002545202.1; XM_002545156.1.
DR   AlphaFoldDB; C4JQG5; -.
DR   STRING; 336963.C4JQG5; -.
DR   GeneID; 8441355; -.
DR   KEGG; ure:UREG_04719; -.
DR   VEuPathDB; FungiDB:UREG_04719; -.
DR   eggNOG; KOG2310; Eukaryota.
DR   HOGENOM; CLU_009535_1_1_1; -.
DR   InParanoid; C4JQG5; -.
DR   OMA; NHLGYGE; -.
DR   OrthoDB; 169704at2759; -.
DR   Proteomes; UP000002058; Unassembled WGS sequence.
DR   GO; GO:0030870; C:Mre11 complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0008296; F:3'-5'-DNA exonuclease activity; IEA:InterPro.
DR   GO; GO:0004520; F:DNA endonuclease activity; IEA:InterPro.
DR   GO; GO:0030145; F:manganese ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006302; P:double-strand break repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR   CDD; cd00840; MPP_Mre11_N; 1.
DR   Gene3D; 3.60.21.10; -; 1.
DR   Gene3D; 3.30.110.110; Mre11, capping domain; 1.
DR   InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR   InterPro; IPR029052; Metallo-depent_PP-like.
DR   InterPro; IPR003701; Mre11.
DR   InterPro; IPR038487; Mre11_capping_dom.
DR   InterPro; IPR007281; Mre11_DNA-bd.
DR   InterPro; IPR041796; Mre11_N.
DR   NCBIfam; TIGR00583; mre11; 1.
DR   PANTHER; PTHR10139; DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11; 1.
DR   PANTHER; PTHR10139:SF1; DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11; 1.
DR   Pfam; PF00149; Metallophos; 1.
DR   Pfam; PF04152; Mre11_DNA_bind; 1.
DR   PIRSF; PIRSF000882; DSB_repair_MRE11; 1.
DR   SMART; SM01347; Mre11_DNA_bind; 1.
DR   SUPFAM; SSF56300; Metallo-dependent phosphatases; 1.
PE   3: Inferred from homology;
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|PIRNR:PIRNR000882};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|PIRNR:PIRNR000882};
KW   Endonuclease {ECO:0000256|ARBA:ARBA00022759,
KW   ECO:0000256|PIRNR:PIRNR000882};
KW   Exonuclease {ECO:0000256|ARBA:ARBA00022839, ECO:0000256|PIRNR:PIRNR000882};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PIRNR:PIRNR000882};
KW   Manganese {ECO:0000256|ARBA:ARBA00023211, ECO:0000256|PIRNR:PIRNR000882};
KW   Meiosis {ECO:0000256|ARBA:ARBA00023254, ECO:0000256|PIRNR:PIRNR000882};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722, ECO:0000256|PIRNR:PIRNR000882};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR000882};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002058}.
FT   DOMAIN          289..466
FT                   /note="Mre11 DNA-binding"
FT                   /evidence="ECO:0000259|SMART:SM01347"
FT   REGION          526..777
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        619..648
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        663..750
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        124
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000882-1"
SQ   SEQUENCE   777 AA;  87056 MW;  6865DB9EE529CE48 CRC64;
     MSLGEADTIR ILVSTDNHVG YNERDPIRGD DSWTTFHEVM CLAKERDVDM VLLAGDLFHE
     NKPSRKSMYQ VMRSLRMNCY GDKPCELEIL SDASENFQGA FNHVNYEDLD INVAIPVFSI
     HGNHDDPSGE GHLAALDILQ VSGLLNYYGR TPESDNVQVK PVLLQKGRTK LALYGLSNVR
     DERLFRTFRD GKVKFFRPSM QQSDWFNLLS VHQNHHSRTE TGYLPETFLP DFMDMVIWGH
     EHECLIEPRL NPETNFHVIQ PGSSVATSLV AGEAVTKHVT ILSITGREFK SEPIRLKTVR
     PFVMKDIVLY EEKEAQKLAR KENNRTEVTR FLMTLVDELI EEAKNDWLES QDGFNGEDSE
     IPLPLVRLRV DTSIPEGGSF DCENPQRFSN RFVGKVANVN DVIQFHRKKK ATTLTRGDAN
     APDETVVSHL ASLDTVKVER LVREFLTAQS LTILPQNSFG DAVSQFIDKD DKHAMEMFLN
     ESLESQIKHL MNLDRDAEEG SDYDEEGARQ TLQAAMDQYR GQLEELFSKG KGKRKGGKRR
     FKPRPDGWES EFDGAWEDQP GALIHSDNEG DPNAEEEEDE VPATNRRRGT AATATRGARG
     GRARGTASSR GKIATTSTRG RGRGRDRQVV SEDDEDNADD RQQEHVMLNE DDEDIDMDDD
     SLFVRQPSTT KSRATATAPS SRARKTTTTA ASARNPPARS TAATRGKQSQ ATLNFSRGSQ
     PSQSQTIAGT SSTSGAGRRP TRSAASKTNI VISDIEDDED DDAFEPIPAS STRSRRR
//
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