ID C4JT03_UNCRE Unreviewed; 1071 AA.
AC C4JT03;
DT 07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 07-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=ATP-dependent RNA helicase DOB1 {ECO:0000313|EMBL:EEP80750.1};
GN ORFNames=UREG_05592 {ECO:0000313|EMBL:EEP80750.1};
OS Uncinocarpus reesii (strain UAMH 1704).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Uncinocarpus.
OX NCBI_TaxID=336963 {ECO:0000313|EMBL:EEP80750.1, ECO:0000313|Proteomes:UP000002058};
RN [1] {ECO:0000313|Proteomes:UP000002058}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UAMH 1704 {ECO:0000313|Proteomes:UP000002058};
RX PubMed=19717792; DOI=10.1101/gr.087551.108;
RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA Henn M.R., Birren B.W., Taylor J.W.;
RT "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT and their relatives.";
RL Genome Res. 19:1722-1731(2009).
CC -!- SIMILARITY: Belongs to the helicase family. SKI2 subfamily.
CC {ECO:0000256|ARBA:ARBA00010140}.
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DR EMBL; CH476617; EEP80750.1; -; Genomic_DNA.
DR RefSeq; XP_002584903.1; XM_002584857.1.
DR AlphaFoldDB; C4JT03; -.
DR STRING; 336963.C4JT03; -.
DR GeneID; 8441098; -.
DR KEGG; ure:UREG_05592; -.
DR VEuPathDB; FungiDB:UREG_05592; -.
DR eggNOG; KOG0948; Eukaryota.
DR HOGENOM; CLU_002902_0_1_1; -.
DR InParanoid; C4JT03; -.
DR OMA; IMLKNYN; -.
DR OrthoDB; 1352at2759; -.
DR Proteomes; UP000002058; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR GO; GO:0006401; P:RNA catabolic process; IEA:InterPro.
DR CDD; cd18024; DEXHc_Mtr4-like; 1.
DR CDD; cd13154; KOW_Mtr4; 1.
DR CDD; cd18795; SF2_C_Ski2; 1.
DR Gene3D; 1.10.3380.30; -; 1.
DR Gene3D; 2.40.30.300; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR048392; MTR4-like_stalk.
DR InterPro; IPR025696; MTR4_beta-barrel.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR016438; SKI2-like.
DR InterPro; IPR012961; Ski2/MTR4_C.
DR PANTHER; PTHR12131; ATP-DEPENDENT RNA AND DNA HELICASE; 1.
DR PANTHER; PTHR12131:SF7; EXOSOME RNA HELICASE MTR4; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF08148; DSHCT; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF21408; MTR4-like_stalk; 1.
DR Pfam; PF13234; MTR4_beta-barrel; 1.
DR PIRSF; PIRSF005198; Antiviral_helicase_SKI2; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM01142; DSHCT; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:EEP80750.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000002058}.
FT DOMAIN 158..314
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 397..598
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..79
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 359..391
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 51..66
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 359..390
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1071 AA; 121062 MW; F6275F2937EE8F9B CRC64;
MDELFDVFEA APASGATPSQ PAKPRPKKDK SKKRQANGDV KEDAVITDVN GADQISAQSE
TEPVLEVQTE QPEPKRPRIE PEPIVADTFE TEQSREIAAS AGLQTTQEGT AVVLSHQVRH
QVALPPNYPY VPISAHKPPE KPARTWPFTL DPFQQVSIAS IERDESVLVS AHTSAGKTVV
AEYAIAHCLK NNQRVIYTSP IKALSNQKYR EFAAEFGDVG LMTGDVTINP TATCLVMTTE
ILRSMLYRGS EIMREVAWVV FDEIHYMRDK TRGVVWEETI ILLPDKVRYV FLSATIPNAM
QFAEWITKTH GQPCHVVYTD FRPTPLQHYL FPAGGEGIRL VVDEKGGFRE ENFQKAMGEI
ADKKGDDPAD TNARGKGKGK NKKTNKGGEK GPSDVFKIVR MIMMKSYNPV IVFSFSKREC
EAHALTLKNL TFNDDSEKDM VSKVFNSAIE MLSDEDKKLP QIVNLLPLLR RGIGVHHSGL
LPILKETIEI LFQENLIKVL FATETFSIGL NMPAKTVVFT NVRKFDGTSQ RWLTPSEFVQ
MSGRAGRRGL DDRGIVIMMV NEEMDPTVVK EIVRGEQDKL NSAFYLGYNM ILNLLRVEGV
SPEFMLERCF AQFQSASSVG TLEKELEELE SQRKNIIIPD EGTIREYYDS RQLLATYNEE
MRLTICKPDY CQRFLDSGRL VNVQHEKHDF GWGLVVNFQQ RKAPRSMQEE YPPHESIIVD
VLLNVAENAH FSYKSDQMLP PGVRPAKKGE NSTMAVVPMV LSCIKAFSTM RITLPKELKS
DDSKKYTAKV LAEVQRRFPD GIPVLDPINE MGIKEEGFKR TLRKVEVVEA RLLANPLHNS
PRLPELYDQY ATKVELGNKI KDTKRQISVA MSIIQLDELK CRKRVLRRFQ FINESEVVQL
KARVACEISS GDELMLSELL FNGFFNTLTP EQCAAVLSVF VFEEKSKETP PITNEELAKP
LRDIQAQARI IAKVGQESKL AINEQEYVES FRWELMEVIY QWAKGGSFAE ICKMTDVYEG
SLIRTFRRLE ECMRQMAQAA KVMGSSDLES KFEASLSMVK RDIVAAQSLY L
//
