ID C4JU28_UNCRE Unreviewed; 664 AA.
AC C4JU28;
DT 07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 07-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=2-dehydropantoate 2-reductase {ECO:0008006|Google:ProtNLM};
GN ORFNames=UREG_05967 {ECO:0000313|EMBL:EEP81125.1};
OS Uncinocarpus reesii (strain UAMH 1704).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Uncinocarpus.
OX NCBI_TaxID=336963 {ECO:0000313|EMBL:EEP81125.1, ECO:0000313|Proteomes:UP000002058};
RN [1] {ECO:0000313|Proteomes:UP000002058}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UAMH 1704 {ECO:0000313|Proteomes:UP000002058};
RX PubMed=19717792; DOI=10.1101/gr.087551.108;
RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA Henn M.R., Birren B.W., Taylor J.W.;
RT "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT and their relatives.";
RL Genome Res. 19:1722-1731(2009).
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DR EMBL; CH476617; EEP81125.1; -; Genomic_DNA.
DR RefSeq; XP_002585278.1; XM_002585232.1.
DR AlphaFoldDB; C4JU28; -.
DR STRING; 336963.C4JU28; -.
DR GeneID; 8438873; -.
DR KEGG; ure:UREG_05967; -.
DR VEuPathDB; FungiDB:UREG_05967; -.
DR eggNOG; ENOG502QT3Z; Eukaryota.
DR HOGENOM; CLU_021479_0_0_1; -.
DR InParanoid; C4JU28; -.
DR OMA; SFKSKAF; -.
DR OrthoDB; 2727909at2759; -.
DR Proteomes; UP000002058; Unassembled WGS sequence.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR013752; KPA_reductase.
DR InterPro; IPR013332; KPR_N.
DR PANTHER; PTHR21708; PROBABLE 2-DEHYDROPANTOATE 2-REDUCTASE; 1.
DR PANTHER; PTHR21708:SF25; PROTEIN PAM1-RELATED; 1.
DR Pfam; PF02558; ApbA; 1.
DR Pfam; PF08546; ApbA_C; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002058}.
FT DOMAIN 11..125
FT /note="Ketopantoate reductase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02558"
FT DOMAIN 150..245
FT /note="Ketopantoate reductase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF08546"
FT REGION 250..325
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 431..454
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 505..664
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 269..284
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 593..664
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 664 AA; 72003 MW; A2DF26501C36A44D CRC64;
MAPSTPRLRV LSVGGNAISA FLAWRLQATN ACDVTLVWKQ NYDHVSQYGI SFKSKVFGNE
RFKPRHVIRS TDEAPSREQG YDYVVLCVKA LPDLYDLGDL IHSVVTPEHT CIIVNTTSTL
ANARASTRSF EANQASTLVI IIVGIVNPYL RLLKKVGVRQ LVSDVIDELI ALAKALGCNF
PDDFKETTIA KMLAQPENPS TMYQDFAARR PMEVETYLGS PIKLGVDSGV KLSRIETLYA
MLHHINVVNQ NRQREPTSPV AALPPRLSSA PRPSTNNMRG GGRSYSSPQG AGHPRRGGPS
MGSHRPPNGY PPSRGPPAQR DPSAEDHNLD EFSHIVHYDA VAGELTQQNG GASNGGSSSA
DLALRERELR IRQRELQLKE QELNMRRGGP NRRMSSHREA LDDDGDYYDA PPPMPQIDPD
NFDMMSVTSR KNRKMPANNA GQFRKNPEMA SGRPPSAFSR AFGMGRNRTS ARIVEEIPGM
HDSLLDNPMM GYSSNRYGNV DRREMHAESR ANSLTASRIN ELGQGVGHGP YPPPSRRTSQ
SPGQGFHPGG RGMGRSSTGI DGFNGPPNGM GHPNRRSPPG MRAPVPRHPS GQPNGAMPQQ
IEQQVGVSNS HSAKGHPNVR SLTGSASASA GSGDSGASAN IDSEASAHSS QSSLPPIFQK
FSGK
//
