ID C4K5N9_HAMD5 Unreviewed; 570 AA.
AC C4K5N9;
DT 07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 07-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=Group II intron encoded reverse transcriptase {ECO:0000313|EMBL:ACQ67882.1};
GN OrderedLocusNames=HDEF_1223 {ECO:0000313|EMBL:ACQ67882.1}, HDEF_1937
GN {ECO:0000313|EMBL:ACQ68525.1};
OS Hamiltonella defensa subsp. Acyrthosiphon pisum (strain 5AT).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; aphid secondary symbionts; Hamiltonella.
OX NCBI_TaxID=572265 {ECO:0000313|EMBL:ACQ67882.1, ECO:0000313|Proteomes:UP000002334};
RN [1] {ECO:0000313|EMBL:ACQ67882.1, ECO:0000313|Proteomes:UP000002334}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=5AT {ECO:0000313|Proteomes:UP000002334}, and T5A
RC {ECO:0000313|EMBL:ACQ67882.1};
RX PubMed=19451630; DOI=10.1073/pnas.0900194106;
RA Degnan P.H., Yu Y., Sisneros N., Wing R.A., Moran N.A.;
RT "Hamiltonella defensa, genome evolution of protective bacterial
RT endosymbiont from pathogenic ancestors.";
RL Proc. Natl. Acad. Sci. U.S.A. 106:9063-9068(2009).
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DR EMBL; CP001277; ACQ67882.1; -; Genomic_DNA.
DR EMBL; CP001277; ACQ68525.1; -; Genomic_DNA.
DR AlphaFoldDB; C4K5N9; -.
DR KEGG; hde:HDEF_1223; -.
DR KEGG; hde:HDEF_1937; -.
DR eggNOG; COG1403; Bacteria.
DR eggNOG; COG3344; Bacteria.
DR HOGENOM; CLU_013584_15_4_6; -.
DR Proteomes; UP000002334; Chromosome.
DR GO; GO:0004519; F:endonuclease activity; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd00085; HNHc; 1.
DR CDD; cd01651; RT_G2_intron; 1.
DR Gene3D; 1.10.30.50; -; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR030931; Group_II_RT_mat.
DR InterPro; IPR002711; HNH.
DR InterPro; IPR003615; HNH_nuc.
DR InterPro; IPR013597; Mat_intron_G2.
DR InterPro; IPR000477; RT_dom.
DR InterPro; IPR025960; RVT_N.
DR NCBIfam; TIGR04416; group_II_RT_mat; 1.
DR PANTHER; PTHR34047:SF8; GROUP II INTRON-ASSOCIATED OPEN READING FRAME; 1.
DR PANTHER; PTHR34047; NUCLEAR INTRON MATURASE 1, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF08388; GIIM; 1.
DR Pfam; PF01844; HNH; 1.
DR Pfam; PF00078; RVT_1; 1.
DR Pfam; PF13655; RVT_N; 1.
DR SMART; SM00507; HNHc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 4: Predicted;
KW Nucleotidyltransferase {ECO:0000313|EMBL:ACQ67882.1};
KW RNA-directed DNA polymerase {ECO:0000313|EMBL:ACQ67882.1};
KW Transferase {ECO:0000313|EMBL:ACQ67882.1}.
FT DOMAIN 96..331
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
SQ SEQUENCE 570 AA; 66831 MW; 6CB06053282089B0 CRC64;
MPMANVINQN YEQQLEWHAI NWRVVTAMIN NLRQRIYRAS ATGDLKKVRN LQKLMMKSRA
NHLLAIRKVT QVNRGKHTAG VDNQVINDHK GREHLYKLLS QTTSEKVYPV KRVYIAKKNG
KKRPLGIPTI LDRCRQAIVK SALEPYWEAK FEPVSYGFRP GRSAHDAIQK IFCIARARGT
RHWVLDADIK GAFDNIDHNF LIKKIGGFPE RNMIKQWLQA GVLEHGNYIP NVAGTPQGGI
ISPLLANIAL HGMETLLGIQ YWKNGTPKQG QPYAVVRYAD DFVVFGKSRE ECETAKIKLQ
IWLAQRGLAL SEEKTSIKHL KEGFDFLGFN IRHYDNRHRK RGYILLTKPS KESMKRYKQQ
MRMTWKGIIG MPTQEGIRQL NAKIIGWCNY YRIGASKRTF SALDQWMWIR QRRYLYRRHP
NKHWWWRRKH YLGKIPGRED YSVFMDKSTG GFLWKHAWTK IQRHWLVPKN ASPDNPELRD
YWRNRQARKQ PFIYGVKVNL YKRQKGYCPL CDQELDNGEQ LHVHHIQPKA EGGDNKLANL
RLLHANCHRQ LHSKKRKNVE VSKLREPYAG
//
