ID   C4K6T7_HAMD5            Unreviewed;       329 AA.
AC   C4K6T7;
DT   07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   07-JUL-2009, sequence version 1.
DT   27-MAR-2024, entry version 55.
DE   SubName: Full=APSE-2 prophage cytolethal distending toxin subunit B {ECO:0000313|EMBL:ACQ68280.1};
GN   Name=cdtB {ECO:0000313|EMBL:ACQ68280.1};
GN   OrderedLocusNames=HDEF_1671 {ECO:0000313|EMBL:ACQ68280.1};
OS   Hamiltonella defensa subsp. Acyrthosiphon pisum (strain 5AT).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; aphid secondary symbionts; Hamiltonella.
OX   NCBI_TaxID=572265 {ECO:0000313|EMBL:ACQ68280.1, ECO:0000313|Proteomes:UP000002334};
RN   [1] {ECO:0000313|EMBL:ACQ68280.1, ECO:0000313|Proteomes:UP000002334}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=5AT {ECO:0000313|Proteomes:UP000002334};
RX   PubMed=19451630; DOI=10.1073/pnas.0900194106;
RA   Degnan P.H., Yu Y., Sisneros N., Wing R.A., Moran N.A.;
RT   "Hamiltonella defensa, genome evolution of protective bacterial
RT   endosymbiont from pathogenic ancestors.";
RL   Proc. Natl. Acad. Sci. U.S.A. 106:9063-9068(2009).
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DR   EMBL; CP001277; ACQ68280.1; -; Genomic_DNA.
DR   RefSeq; WP_015874046.1; NC_012751.1.
DR   AlphaFoldDB; C4K6T7; -.
DR   STRING; 572265.HDEF_1671; -.
DR   GeneID; 66261271; -.
DR   KEGG; hde:HDEF_1671; -.
DR   eggNOG; COG3021; Bacteria.
DR   HOGENOM; CLU_091266_0_0_6; -.
DR   Proteomes; UP000002334; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   CDD; cd09081; CdtB; 1.
DR   Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR   InterPro; IPR003539; CD_toxinB.
DR   InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR   InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR   Pfam; PF03372; Exo_endo_phos; 1.
DR   SUPFAM; SSF56219; DNase I-like; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        20..38
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          54..265
FT                   /note="Endonuclease/exonuclease/phosphatase"
FT                   /evidence="ECO:0000259|Pfam:PF03372"
FT   REGION          273..295
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        273..287
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   329 AA;  37623 MW;  C4348E615D45CFB2 CRC64;
     MKNFTKIVKD HFILLYKKQL VKSFSIFMFV CFFIPISYSQ SHNHNRDVKD FIFGTWNTNG
     ARWNDVRNLM VNGQFDVLAI QEAGALPTSS RNEGSVTESH DYNSIVNEAQ RLCYIGEINQ
     NDVLFGTVRE YSWQTSRGES FYLYYYDRRD HYVMSNGNQY PRVNTAIITR QRADNIFFTA
     PIYTNQRRTN INRPIIGIRL ENAVFFNVHA APDRGGRNEA GSAVNIIRDY MAMNSPNHTW
     AMIGDFNRIP SELNSEILSS TPPMQTFIEN VHTGESTHES PNPSSSRELD YGVLGGSASH
     SDHHVSAIIA LYLLQLSMNP SDHKPVKFN
//