ID C4K843_HAMD5 Unreviewed; 394 AA.
AC C4K843;
DT 07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 07-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=2-octaprenyl-6-methoxyphenol hydroxylase, FAD/NAD(P)-binding {ECO:0000313|EMBL:ACQ66803.1};
GN Name=ubiH {ECO:0000313|EMBL:ACQ66803.1};
GN OrderedLocusNames=HDEF_0027 {ECO:0000313|EMBL:ACQ66803.1};
OS Hamiltonella defensa subsp. Acyrthosiphon pisum (strain 5AT).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; aphid secondary symbionts; Hamiltonella.
OX NCBI_TaxID=572265 {ECO:0000313|EMBL:ACQ66803.1, ECO:0000313|Proteomes:UP000002334};
RN [1] {ECO:0000313|EMBL:ACQ66803.1, ECO:0000313|Proteomes:UP000002334}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=5AT {ECO:0000313|Proteomes:UP000002334};
RX PubMed=19451630; DOI=10.1073/pnas.0900194106;
RA Degnan P.H., Yu Y., Sisneros N., Wing R.A., Moran N.A.;
RT "Hamiltonella defensa, genome evolution of protective bacterial
RT endosymbiont from pathogenic ancestors.";
RL Proc. Natl. Acad. Sci. U.S.A. 106:9063-9068(2009).
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- SIMILARITY: Belongs to the UbiH/COQ6 family.
CC {ECO:0000256|ARBA:ARBA00005349}.
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DR EMBL; CP001277; ACQ66803.1; -; Genomic_DNA.
DR RefSeq; WP_012737768.1; NC_012751.1.
DR AlphaFoldDB; C4K843; -.
DR STRING; 572265.HDEF_0027; -.
DR GeneID; 66259971; -.
DR KEGG; hde:HDEF_0027; -.
DR eggNOG; COG0654; Bacteria.
DR HOGENOM; CLU_009665_8_1_6; -.
DR UniPathway; UPA00232; -.
DR Proteomes; UP000002334; Chromosome.
DR GO; GO:0008681; F:2-octaprenyl-6-methoxyphenol hydroxylase activity; IEA:InterPro.
DR GO; GO:0071949; F:FAD binding; IEA:InterPro.
DR GO; GO:0006744; P:ubiquinone biosynthetic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 2.
DR InterPro; IPR002938; FAD-bd.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR011295; UbiH.
DR InterPro; IPR010971; UbiH/COQ6.
DR NCBIfam; TIGR01988; Ubi-OHases; 1.
DR NCBIfam; TIGR01984; UbiH; 1.
DR PANTHER; PTHR43876; UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43876:SF7; UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL; 1.
DR Pfam; PF01494; FAD_binding_3; 1.
DR PRINTS; PR00420; RNGMNOXGNASE.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 3: Inferred from homology;
KW Monooxygenase {ECO:0000256|ARBA:ARBA00023033};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT DOMAIN 3..344
FT /note="FAD-binding"
FT /evidence="ECO:0000259|Pfam:PF01494"
SQ SEQUENCE 394 AA; 43556 MW; 5CF315FD1A47A353 CRC64;
MGVIIVGGGM VGSTLALAVA FLTRGQIPIR LIEAFVPDQN ASFSDDKRAI ALAHGTCQQL
ERLGIWKPLS HDATPITNIH VSDQGQCGFV HLRAQDHHIP FLGQVLSLKT AQNRLFSLLK
STPGIQLYCP AQVLQISRTQ KMVRVTLNHG ETLEAPLLIA ADGSHSSLAQ ACHIQYQKKD
YQQFAVTTHI RTEKALGSCA FERFTSEGPL ALLPISQEES ALVWCHSQAN RFLVEAWNDA
DFLQQLQNTF GWRLGKILKV GPRYSTPLYL TFASRHISHR LALVGNSAQT LHPVSGQGFN
LGLRDTMTLA QILAEAAAKG DDLGEYSVLN QYQRQRQKDQ QNMITLTEGL VHLFSNALKP
LVVARHLGLM TMEEGPFFAQ LLSRSTLGWS HPRD
//
