ID C4K8V6_HAMD5 Unreviewed; 436 AA.
AC C4K8V6;
DT 07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 07-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=Cytosine transport protein (NCS1 family) {ECO:0000313|EMBL:ACQ66943.1};
GN Name=codB_1 {ECO:0000313|EMBL:ACQ66943.1};
GN OrderedLocusNames=HDEF_0170 {ECO:0000313|EMBL:ACQ66943.1};
OS Hamiltonella defensa subsp. Acyrthosiphon pisum (strain 5AT).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; aphid secondary symbionts; Hamiltonella.
OX NCBI_TaxID=572265 {ECO:0000313|EMBL:ACQ66943.1, ECO:0000313|Proteomes:UP000002334};
RN [1] {ECO:0000313|EMBL:ACQ66943.1, ECO:0000313|Proteomes:UP000002334}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=5AT {ECO:0000313|Proteomes:UP000002334};
RX PubMed=19451630; DOI=10.1073/pnas.0900194106;
RA Degnan P.H., Yu Y., Sisneros N., Wing R.A., Moran N.A.;
RT "Hamiltonella defensa, genome evolution of protective bacterial
RT endosymbiont from pathogenic ancestors.";
RL Proc. Natl. Acad. Sci. U.S.A. 106:9063-9068(2009).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the purine-cytosine permease (2.A.39) family.
CC {ECO:0000256|ARBA:ARBA00008974}.
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DR EMBL; CP001277; ACQ66943.1; -; Genomic_DNA.
DR RefSeq; WP_012737908.1; NC_012751.1.
DR AlphaFoldDB; C4K8V6; -.
DR STRING; 572265.HDEF_0170; -.
DR GeneID; 66260105; -.
DR KEGG; hde:HDEF_0170; -.
DR eggNOG; COG1457; Bacteria.
DR HOGENOM; CLU_035711_0_0_6; -.
DR Proteomes; UP000002334; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015209; F:cytosine transmembrane transporter activity; IEA:InterPro.
DR CDD; cd11484; SLC-NCS1sbd_CobB-like; 1.
DR Gene3D; 1.10.4160.10; Hydantoin permease; 1.
DR InterPro; IPR030191; CodB.
DR InterPro; IPR001248; Pur-cyt_permease.
DR PANTHER; PTHR30569:SF0; CYTOSINE PERMEASE; 1.
DR PANTHER; PTHR30569; CYTOSINE TRANSPORTER CODB; 1.
DR Pfam; PF02133; Transp_cyt_pur; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 28..51
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 57..83
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 95..118
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 138..156
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 163..190
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 202..223
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 235..261
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 267..287
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 313..335
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 341..363
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 384..406
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 412..431
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 436 AA; 46674 MW; E16D53027C4E093D CRC64;
MVEIMKNKLP NTHDFCFMRV PADCRSSLFT MVMVRIGIMT ALGQFMLGAM LGHTMSFYDA
LMATFLGSML LEFVSLGLGI AGAREGFSTS QLARWCGFGF YGSSLVSILI AFSLIGWFGV
QNAILANGLN YALNNKPGFV ICALLSGLGL TALMTFGFRA LGWIAIVTVP LFMLVVGWIV
CELLAGYHLI ELMTTLPTGE PMTLGMAATA VGGGYIVAAV ATADIGRYCQ NGRHVFWMIT
LSIIVGEFVV NSIAILIAHA LNTSDVVTIM TQTAGWIGLL AVILSALKIN DSNLYSSSLA
LLSAVEVISG RRLSYVGLTL VLGTAGTLLT VAGILEKFTG FLLLLGVMFP PVAGVMLCDY
WLLKTHRVEL DESLRQQQLP DPKILPAVGW NGVIACLAGI LTGLMIKMGI PSLNSLLVSI
TVYALLNGYP FKKAVK
//
