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Database: UniProt
Entry: C4LBT8_TOLAT
LinkDB: C4LBT8_TOLAT
Original site: C4LBT8_TOLAT 
ID   C4LBT8_TOLAT            Unreviewed;       858 AA.
AC   C4LBT8;
DT   07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   07-JUL-2009, sequence version 1.
DT   24-JAN-2024, entry version 92.
DE   RecName: Full=Chaperone protein ClpB {ECO:0000256|ARBA:ARBA00017574, ECO:0000256|RuleBase:RU362034};
GN   Name=clpB {ECO:0000256|RuleBase:RU362034};
GN   OrderedLocusNames=Tola_2769 {ECO:0000313|EMBL:ACQ94362.1};
OS   Tolumonas auensis (strain DSM 9187 / TA4).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Aeromonadales;
OC   Aeromonadaceae; Tolumonas.
OX   NCBI_TaxID=595494 {ECO:0000313|EMBL:ACQ94362.1, ECO:0000313|Proteomes:UP000009073};
RN   [1] {ECO:0000313|Proteomes:UP000009073}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 9187 / TA4 {ECO:0000313|Proteomes:UP000009073};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D.,
RA   Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C., Han C.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Spring S.,
RA   Beller H.;
RT   "Complete sequence of Tolumonas auensis DSM 9187.";
RL   Submitted (MAY-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ACQ94362.1, ECO:0000313|Proteomes:UP000009073}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 9187 / TA4 {ECO:0000313|Proteomes:UP000009073};
RX   PubMed=22180815; DOI=10.4056/sigs.2184986;
RA   Chertkov O., Copeland A., Lucas S., Lapidus A., Berry K.W., Detter J.C.,
RA   Del Rio T.G., Hammon N., Dalin E., Tice H., Pitluck S., Richardson P.,
RA   Bruce D., Goodwin L., Han C., Tapia R., Saunders E., Schmutz J.,
RA   Brettin T., Larimer F., Land M., Hauser L., Spring S., Rohde M.,
RA   Kyrpides N.C., Ivanova N., Goker M., Beller H.R., Klenk H.P., Woyke T.;
RT   "Complete genome sequence of Tolumonas auensis type strain (TA 4).";
RL   Stand. Genomic Sci. 5:112-120(2011).
CC   -!- FUNCTION: Part of a stress-induced multi-chaperone system, it is
CC       involved in the recovery of the cell from heat-induced damage, in
CC       cooperation with DnaK, DnaJ and GrpE. {ECO:0000256|RuleBase:RU362034}.
CC   -!- SUBUNIT: Homohexamer. The oligomerization is ATP-dependent.
CC       {ECO:0000256|ARBA:ARBA00026057}.
CC   -!- SUBUNIT: Homohexamer; The oligomerization is ATP-dependent.
CC       {ECO:0000256|RuleBase:RU362034}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU362034}.
CC   -!- SIMILARITY: Belongs to the ClpA/ClpB family.
CC       {ECO:0000256|ARBA:ARBA00008675, ECO:0000256|RuleBase:RU004432}.
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DR   EMBL; CP001616; ACQ94362.1; -; Genomic_DNA.
DR   RefSeq; WP_015879811.1; NC_012691.1.
DR   AlphaFoldDB; C4LBT8; -.
DR   STRING; 595494.Tola_2769; -.
DR   KEGG; tau:Tola_2769; -.
DR   eggNOG; COG0542; Bacteria.
DR   HOGENOM; CLU_005070_4_0_6; -.
DR   OMA; SKMMQGE; -.
DR   OrthoDB; 9803641at2; -.
DR   Proteomes; UP000009073; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0042026; P:protein refolding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009408; P:response to heat; IEA:UniProtKB-UniRule.
DR   CDD; cd00009; AAA; 1.
DR   CDD; cd19499; RecA-like_ClpB_Hsp104-like; 1.
DR   Gene3D; 1.10.8.60; -; 1.
DR   Gene3D; 1.10.1780.10; Clp, N-terminal domain; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR017730; Chaperonin_ClpB.
DR   InterPro; IPR019489; Clp_ATPase_C.
DR   InterPro; IPR036628; Clp_N_dom_sf.
DR   InterPro; IPR004176; Clp_R_dom.
DR   InterPro; IPR001270; ClpA/B.
DR   InterPro; IPR018368; ClpA/B_CS1.
DR   InterPro; IPR028299; ClpA/B_CS2.
DR   InterPro; IPR041546; ClpA/ClpB_AAA_lid.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   NCBIfam; TIGR03346; chaperone_ClpB; 1.
DR   PANTHER; PTHR11638; ATP-DEPENDENT CLP PROTEASE; 1.
DR   PANTHER; PTHR11638:SF18; HEAT SHOCK PROTEIN 104; 1.
DR   Pfam; PF00004; AAA; 1.
DR   Pfam; PF07724; AAA_2; 1.
DR   Pfam; PF17871; AAA_lid_9; 1.
DR   Pfam; PF02861; Clp_N; 2.
DR   Pfam; PF10431; ClpB_D2-small; 1.
DR   PRINTS; PR00300; CLPPROTEASEA.
DR   SMART; SM00382; AAA; 2.
DR   SMART; SM01086; ClpB_D2-small; 1.
DR   SUPFAM; SSF81923; Double Clp-N motif; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR   PROSITE; PS51903; CLP_R; 1.
DR   PROSITE; PS00870; CLPAB_1; 1.
DR   PROSITE; PS00871; CLPAB_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU004432};
KW   Chaperone {ECO:0000256|ARBA:ARBA00023186, ECO:0000256|RuleBase:RU004432};
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|RuleBase:RU362034};
KW   Cytoplasm {ECO:0000256|RuleBase:RU362034};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU004432};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009073};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|PROSITE-
KW   ProRule:PRU01251}; Stress response {ECO:0000256|RuleBase:RU362034}.
FT   DOMAIN          3..146
FT                   /note="Clp R"
FT                   /evidence="ECO:0000259|PROSITE:PS51903"
FT   COILED          405..432
FT                   /evidence="ECO:0000256|RuleBase:RU362034"
SQ   SEQUENCE   858 AA;  96420 MW;  6CB520B3ECC8C9E4 CRC64;
     MRLDRLTSKF QTAISDAQSL ALGKDHQFIE PIHIMTALLD QQGGSIRPLL ILAGCNVDTL
     HQRLTQELDR LPRVSGVDGD IQISPQLGRI LNMCDKLSQQ RQDQFISSEM FLLAALDDRG
     TLGDLLRQNG VVKDKLDKAI EKVRGGEKVT DAGAEEKRQA LEKYTIDLTE RAEQGKLDPV
     IGRDEEIRRT VQVLQRRTKN NPVLIGEPGV GKTAIVEGLA QRIINGEVPE GLKHKRVLSL
     DMGSLLAGAK YRGEFEERLK AVLNELAKQE GNVILFIDEL HTMVGAGKAE GAMDAGNMLK
     PALARGELHC VGATTLDEYR QYVEKDAALE RRFQKVLVDQ PSVEDTIAIL RGLKERYELH
     HHVQITDPAI VAAATLSHRY ISDRQLPDKA IDLIDEAAAS IRLQIDSKPE QLDRLERRIV
     QLKMEQQALM KESDVASAQR LGIINKEITE KDREYNELEE IWKAEKAALA GTQHIKSELE
     QARQELDVAR RAGDLAKMSE LHYGRIPELE KQLDLASQAE MQEQTLLRNR VTDEEIAEVL
     SRWTGIPVAR MLEGERDKLL RMEEKLHQRV IGQDEAVNAV ANAIRRSRAG LSDPMRPIGS
     FLFLGPTGVG KTELCKALAE FLFDTQDAMV RIDMSEFMEK HSVARLVGAP PGYVGYEEGG
     YLTEAVRRKP YSVILLDEVE KAHPDVFNIL LQVLDDGRLT DGQGRTVDFR NAVIIMTSNL
     GSDLIQEHHH LMEYQEMKSM LMEVLTRSFR PEFLNRIDET VVFHPLGAEH IQSIAKIQLQ
     SLVKRLEDIG YKVELRDSLL SYLAQSGFDP VYGARPLKRA IQQQVENPLA QDILSGKVLP
     GKTLILDIRD DKLVIEQD
//
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