ID C4LHQ6_CORK4 Unreviewed; 298 AA.
AC C4LHQ6;
DT 07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 07-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=Putative oxidoreductase {ECO:0000313|EMBL:ACR17361.1};
GN OrderedLocusNames=ckrop_0596 {ECO:0000313|EMBL:ACR17361.1};
OS Corynebacterium kroppenstedtii (strain DSM 44385 / JCM 11950 / CIP 105744 /
OS CCUG 35717).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales;
OC Corynebacteriaceae; Corynebacterium.
OX NCBI_TaxID=645127 {ECO:0000313|EMBL:ACR17361.1, ECO:0000313|Proteomes:UP000001473};
RN [1] {ECO:0000313|EMBL:ACR17361.1, ECO:0000313|Proteomes:UP000001473}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44385 / JCM 11950 / CIP 105744 / CCUG 35717
RC {ECO:0000313|Proteomes:UP000001473};
RX PubMed=18430482; DOI=10.1016/j.jbiotec.2008.03.004;
RA Tauch A., Schneider J., Szczepanowski R., Tilker A., Viehoever P.,
RA Gartemann K.-H., Arnold W., Blom J., Brinkrolf K., Brune I., Goetker S.,
RA Weisshaar B., Goesmann A., Droege M., Puehler A.;
RT "Ultrafast pyrosequencing of Corynebacterium kroppenstedtii DSM44385
RT revealed insights into the physiology of a lipophilic corynebacterium that
RT lacks mycolic acids.";
RL J. Biotechnol. 136:22-30(2008).
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DR EMBL; CP001620; ACR17361.1; -; Genomic_DNA.
DR RefSeq; WP_012731248.1; NC_012704.1.
DR AlphaFoldDB; C4LHQ6; -.
DR STRING; 645127.ckrop_0596; -.
DR KEGG; ckp:ckrop_0596; -.
DR eggNOG; COG0656; Bacteria.
DR HOGENOM; CLU_023205_0_1_11; -.
DR OrthoDB; 9804790at2; -.
DR Proteomes; UP000001473; Chromosome.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0071704; P:organic substance metabolic process; IEA:UniProt.
DR GO; GO:0044281; P:small molecule metabolic process; IEA:UniProt.
DR Gene3D; 3.20.20.100; NADP-dependent oxidoreductase domain; 1.
DR InterPro; IPR020471; AKR.
DR InterPro; IPR018170; Aldo/ket_reductase_CS.
DR InterPro; IPR023210; NADP_OxRdtase_dom.
DR InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR PANTHER; PTHR43827; 2,5-DIKETO-D-GLUCONIC ACID REDUCTASE; 1.
DR PANTHER; PTHR43827:SF3; ALDO-KETO REDUCTASE; 1.
DR Pfam; PF00248; Aldo_ket_red; 1.
DR PIRSF; PIRSF000097; AKR; 1.
DR PRINTS; PR00069; ALDKETRDTASE.
DR SUPFAM; SSF51430; NAD(P)-linked oxidoreductase; 1.
DR PROSITE; PS00798; ALDOKETO_REDUCTASE_1; 1.
DR PROSITE; PS00062; ALDOKETO_REDUCTASE_2; 1.
DR PROSITE; PS00063; ALDOKETO_REDUCTASE_3; 1.
PE 4: Predicted;
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Reference proteome {ECO:0000313|Proteomes:UP000001473}.
FT DOMAIN 25..274
FT /note="NADP-dependent oxidoreductase"
FT /evidence="ECO:0000259|Pfam:PF00248"
FT ACT_SITE 52
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-1"
FT BINDING 110
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-2"
FT SITE 77
FT /note="Lowers pKa of active site Tyr"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-3"
SQ SEQUENCE 298 AA; 32924 MW; 312250C648ADEB43 CRC64;
MTNSIPTLTL NNGVELPSLG FGVFQSSPED TAQAVETALR TGYRHIDTAA IYGNEREVGE
GLRNSGVSRD EVFLETKVWI NDFGYDKTRH AFDKSAGKLG VDTIDLLILH QSLPSHFDLT
LDAYRGLESL LKEGRVRAIG VSNFLPEHLD KLVEETEVVP AVNQVEIHPY FRNTETLEAD
AKHGVLSQAW SPIGGITFYP GWGEDRTSTL DNPTLKEIGA KYGKTAAQVM LRWHIDEGRS
AIPKSVHESR IKENFDVFDF SLTKDELATI DALDTGHRTG PAPTDITIEE YGADIPEA
//
