ID C4N360_HUMAN Unreviewed; 444 AA.
AC C4N360;
DT 07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 07-JUL-2009, sequence version 1.
DT 24-JAN-2024, entry version 77.
DE SubName: Full=KIR3DL1 {ECO:0000313|EMBL:AAX89514.1, ECO:0000313|EMBL:ACJ37429.1};
DE SubName: Full=Killer cell immunoglobulin-like receptor 3DL1 {ECO:0000313|Ensembl:ENSP00000481282.1};
GN Name=KIR3DL1 {ECO:0000313|EMBL:ACJ37429.1,
GN ECO:0000313|Ensembl:ENSP00000481282.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|EMBL:ACJ37429.1};
RN [1] {ECO:0000313|Ensembl:ENSP00000481282.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [2] {ECO:0000313|EMBL:AAX89514.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=17694054; DOI=10.1038/ng2111;
RA Norman P.J., Abi-Rached L., Gendzekhadze K., Korbel D., Gleimer M.,
RA Rowley D., Bruno D., Carrington C.V., Chandanayingyong D., Chang Y.H.,
RA Crespi C., Saruhan-Direskeneli G., Fraser P.A., Hameed K., Kamkamidze G.,
RA Koram K.A., Layrisse Z., Matamoros N., Mila J., Park M.H., Pitchappan R.M.,
RA Ramdath D.D., Shiau M.Y., Stephens H.A., Struik S., Verity D.H.,
RA Vaughan R.W., Tyan D., Davis R.W., Riley E.M., Ronaghi M., Parham P.;
RT "Unusual selection on the KIR3DL1/S1 natural killer cell receptor in
RT Africans.";
RL Nat. Genet. 39:1092-1099(2007).
RN [3] {ECO:0000313|EMBL:ACJ37429.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=19411600; DOI=10.1101/gr.085738.108;
RA Norman P.J., Abi-Rached L., Gendzekhadze K., Hammond J.A., Moesta A.K.,
RA Sharma D., Graef T., McQueen K.L., Guethlein L.A., Carrington C.V.F.,
RA Chandanayingyong D., Chang Y.-H., Crespi C., Saruhan-Direskeneli G.,
RA Hameed K., Kamkamidze G., Koram K.A., Layrisse Z., Matamoros N., Mila J.,
RA Park M.H., Pitshappan R.M., Ramdath D.D., Shiau M.-Y., Stephens H.A.F.,
RA Struik S., Tyan D., Verity D.H., Vaughan R.W., Davis R.W., Fraser P.A.,
RA Riley E.M., Ronaghi M., Parham P.;
RT "Meiotic recombination generates rich diversity in NK cell receptor genes,
RT alleles, and haplotypes.";
RL Genome Res. 19:757-769(2009).
RN [4] {ECO:0000313|Ensembl:ENSP00000481282.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2022) to UniProtKB.
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DR EMBL; GU182350; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; GU182353; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AY760043; AAX89514.1; -; Genomic_DNA.
DR EMBL; FJ158655; ACJ37429.1; -; Genomic_DNA.
DR AlphaFoldDB; C4N360; -.
DR SMR; C4N360; -.
DR MassIVE; C4N360; -.
DR Ensembl; ENST00000610345.4; ENSP00000481653.1; ENSG00000277175.5.
DR Ensembl; ENST00000615523.4; ENSP00000481282.1; ENSG00000278427.5.
DR UCSC; uc061euf.1; human.
DR HGNC; HGNC:6338; KIR3DL1.
DR Proteomes; UP000005640; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd05711; IgC2_D2_LILR_KIR_like; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013151; Immunoglobulin.
DR PANTHER; PTHR11738:SF166; KILLER CELL IMMUNOGLOBULIN-LIKE RECEPTOR 3DL1-RELATED; 1.
DR PANTHER; PTHR11738; MHC CLASS I NK CELL RECEPTOR; 1.
DR Pfam; PF00047; ig; 3.
DR SMART; SM00409; IG; 3.
DR SUPFAM; SSF48726; Immunoglobulin; 3.
PE 1: Evidence at protein level;
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Proteomics identification {ECO:0007829|MaxQB:C4N360,
KW ECO:0007829|ProteomicsDB:C4N360};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..444
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014086363"
FT TRANSMEM 339..363
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 34..118
FT /note="Immunoglobulin subtype"
FT /evidence="ECO:0000259|SMART:SM00409"
FT DOMAIN 129..209
FT /note="Immunoglobulin subtype"
FT /evidence="ECO:0000259|SMART:SM00409"
FT DOMAIN 229..316
FT /note="Immunoglobulin subtype"
FT /evidence="ECO:0000259|SMART:SM00409"
FT REGION 315..334
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 375..394
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 409..444
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 409..427
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 444 AA; 49112 MW; B3604505E05F9934 CRC64;
MLLMVVSMAC VGFFLVQRAG PHVGGQDKPF LSAWPSAVVP RGGHVTLRCH YRHRFNNFML
YKEDRIHVPI FHGRLFQESF NMSPVTTAHA GNYTCRGSHP HSPTGWSAPS NPVVIMVTGN
HRKPSLLAHP GPLVKSGERV ILQCWSDIMF EHFFLHKEGI SKDPSRLVGQ IHDGVSKANF
SIGPMMLALA GTYRCYGSVT HTPYQLSAPS DPLDIVVTGP YEKPSLSAQP GPKVQAGESV
TLSCSSRSSY DMYHLSREGG AHERRLPAVR KVNRTFKADF PLGPATHGGT YRCFGSFRHS
PYEWSDPSDP LLVSVTGNPS SSWPSPTEPS SKSGNPRHLH ILIGTSVVII LFILLLFFLL
HLWCSNKKNA AVMDQEPAGN RTANSEDSDE QDPEEVTYAQ LDHCVFTQRK ITRPSQRPKT
PPTDTILYTE LPNAKPRSKV VSCP
//