ID C4P7J2_CHICK Unreviewed; 529 AA.
AC C4P7J2;
DT 07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 07-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 100.
DE SubName: Full=Glucagon-like peptide 2 receptor {ECO:0000313|EMBL:ACQ66640.1, ECO:0000313|Ensembl:ENSGALP00010043249.1};
GN Name=GLP2R {ECO:0000313|EMBL:ACQ66640.1,
GN ECO:0000313|Ensembl:ENSGALP00010043249.1};
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031 {ECO:0000313|EMBL:ACQ66640.1};
RN [1] {ECO:0000313|EMBL:ACQ66640.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Intestine {ECO:0000313|EMBL:ACQ66640.1};
RX PubMed=18299131; DOI=10.1016/j.ygcen.2008.01.014;
RA Richards M.P., McMurtry J.P.;
RT "Expression of proglucagon and proglucagon-derived peptide hormone receptor
RT genes in the chicken.";
RL Gen. Comp. Endocrinol. 156:323-338(2008).
RN [2] {ECO:0000313|EMBL:ACQ66640.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Intestine {ECO:0000313|EMBL:ACQ66640.1};
RA Nag N., Richards M.P.;
RL Submitted (APR-2009) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSGALP00010043249.1}
RP IDENTIFICATION.
RC STRAIN=broiler {ECO:0000313|Ensembl:ENSGALP00010043249.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC {ECO:0000256|ARBA:ARBA00005314}.
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DR EMBL; FJ899744; ACQ66640.1; -; mRNA.
DR RefSeq; NP_001156720.1; NM_001163248.1.
DR STRING; 9031.ENSGALP00000052073; -.
DR PaxDb; 9031-ENSGALP00000042964; -.
DR Ensembl; ENSGALT00010070558.1; ENSGALP00010043249.1; ENSGALG00010029195.1.
DR GeneID; 427787; -.
DR KEGG; gga:427787; -.
DR CTD; 9340; -.
DR VEuPathDB; HostDB:geneid_427787; -.
DR eggNOG; KOG4564; Eukaryota.
DR GeneTree; ENSGT00940000158127; -.
DR HOGENOM; CLU_002753_4_0_1; -.
DR Reactome; R-GGA-418555; G alpha (s) signalling events.
DR Reactome; R-GGA-420092; Glucagon-type ligand receptors.
DR Proteomes; UP000000539; Chromosome 18.
DR Bgee; ENSGALG00000041800; Expressed in colon and 3 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004967; F:glucagon receptor activity; IBA:GO_Central.
DR GO; GO:0017046; F:peptide hormone binding; IBA:GO_Central.
DR GO; GO:0007188; P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR CDD; cd15266; 7tmB1_GLP2R; 1.
DR Gene3D; 4.10.1240.10; GPCR, family 2, extracellular hormone receptor domain; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR039125; 7tmB1_GLP2R.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR InterPro; IPR001879; GPCR_2_extracellular_dom.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR PANTHER; PTHR45620:SF23; GLUCAGON-LIKE PEPTIDE 2 RECEPTOR; 1.
DR PANTHER; PTHR45620; PDF RECEPTOR-LIKE PROTEIN-RELATED; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF02793; HRM; 1.
DR PRINTS; PR00249; GPCRSECRETIN.
DR SMART; SM00008; HormR; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR SUPFAM; SSF111418; Hormone receptor domain; 1.
DR PROSITE; PS00649; G_PROTEIN_RECEP_F2_1; 1.
DR PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
PE 2: Evidence at transcript level;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:ACQ66640.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000539};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..529
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014302090"
FT TRANSMEM 154..174
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 186..204
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 250..270
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 277..295
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 315..337
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 358..379
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 391..414
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 54..137
FT /note="G-protein coupled receptors family 2 profile 1"
FT /evidence="ECO:0000259|PROSITE:PS50227"
FT DOMAIN 152..415
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 505..529
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 529 AA; 60572 MW; 48BB5210ADB8AA3F CRC64;
MGMIILFGLC SSMGIWSGIS PIPASSVMIL FLVKQAKGSL LEKTTTGWNK YKQECLKMLQ
ESTVGTGIRC NGTFDQFVCW PYSTPGKVSV PCPSYLPWLE NGSAGNVYRV CLDEGTWQTK
ENSTDIWRDS SECSEKNNLQ KNEEEHKLLT TLQLLYTIGY CFSLISLVLA LLILSLLRKL
HCTRNYIHMN LFASFILRAT AILIKDTVLH KIYSKRPNDE TGWILYLSPE ILIICRAAQF
FMHYFVGANY FWLLVEGIYL HTLLITAVLS ERRLLQTYIV IGWAVPILFV APWGISRSKL
ENTGCWGTNE HMGIWWIIRG PMLFSITVNF GIFLKILRML ISKLKAQQMS FHDYKYRLAR
STLVLIPLLG IHEFIFSFIT DEQVEGFLRH VRLFIQLTMS SFHGFFVAVL YCFANGEVKA
ELHKQWSRFL LAEPFGRKLC FLGQNIKYLR KCSQKEKKQH LSSNHLCLEV SEPWDMKLQQ
VLAKQRAVPC TELGHALPSR LRASVSDSSE GEVTTGETTE EVVFEESEI
//