ID   C4QKQ7_SCHMA            Unreviewed;       618 AA.
AC   C4QKQ7;
DT   07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   07-JUL-2009, sequence version 1.
DT   24-JAN-2024, entry version 67.
DE   SubName: Full=Fascin, putative {ECO:0000313|WBParaSite:Smp_169730.1};
OS   Schistosoma mansoni (Blood fluke).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC   Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX   NCBI_TaxID=6183 {ECO:0000313|Proteomes:UP000008854, ECO:0000313|WBParaSite:Smp_169730.1};
RN   [1] {ECO:0000313|Proteomes:UP000008854}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Puerto Rican {ECO:0000313|Proteomes:UP000008854};
RX   PubMed=22253936; DOI=10.1371/journal.pntd.0001455;
RA   Protasio A.V., Tsai I.J., Babbage A., Nichol S., Hunt M., Aslett M.A.,
RA   De Silva N., Velarde G.S., Anderson T.J., Clark R.C., Davidson C.,
RA   Dillon G.P., Holroyd N.E., LoVerde P.T., Lloyd C., McQuillan J.,
RA   Oliveira G., Otto T.D., Parker-Manuel S.J., Quail M.A., Wilson R.A.,
RA   Zerlotini A., Dunne D.W., Berriman M.;
RT   "A systematically improved high quality genome and transcriptome of the
RT   human blood fluke Schistosoma mansoni.";
RL   PLoS Negl. Trop. Dis. 6:E1455-E1455(2012).
RN   [2] {ECO:0000313|WBParaSite:Smp_169730.1}
RP   IDENTIFICATION.
RC   STRAIN=Puerto Rican {ECO:0000313|WBParaSite:Smp_169730.1};
RG   WormBaseParasite;
RL   Submitted (DEC-2018) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC       {ECO:0000256|ARBA:ARBA00004245}.
CC   -!- SIMILARITY: Belongs to the fascin family.
CC       {ECO:0000256|ARBA:ARBA00007415}.
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DR   RefSeq; XP_018644373.1; XM_018792634.1.
DR   AlphaFoldDB; C4QKQ7; -.
DR   STRING; 6183.C4QKQ7; -.
DR   EnsemblMetazoa; Smp_169730.1; Smp_169730.1; Smp_169730.
DR   GeneID; 8355389; -.
DR   KEGG; smm:Smp_169730; -.
DR   WBParaSite; Smp_169730.1; Smp_169730.1; Smp_169730.
DR   CTD; 8355389; -.
DR   eggNOG; ENOG502QPRX; Eukaryota.
DR   HOGENOM; CLU_442345_0_0_1; -.
DR   InParanoid; C4QKQ7; -.
DR   OMA; NRISIAC; -.
DR   OrthoDB; 5484756at2759; -.
DR   PhylomeDB; C4QKQ7; -.
DR   Proteomes; UP000008854; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR   GO; GO:0030674; F:protein-macromolecule adaptor activity; IEA:InterPro.
DR   GO; GO:0007015; P:actin filament organization; IEA:InterPro.
DR   Gene3D; 2.80.10.50; -; 3.
DR   InterPro; IPR008999; Actin-crosslinking.
DR   InterPro; IPR010431; Fascin.
DR   InterPro; IPR022768; Fascin-domain.
DR   PANTHER; PTHR10551; FASCIN; 1.
DR   PANTHER; PTHR10551:SF9; PROTEIN SINGED; 1.
DR   Pfam; PF06268; Fascin; 2.
DR   SUPFAM; SSF50405; Actin-crosslinking proteins; 3.
PE   3: Inferred from homology;
KW   Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008854}.
FT   DOMAIN          25..127
FT                   /note="Fascin"
FT                   /evidence="ECO:0000259|Pfam:PF06268"
FT   DOMAIN          208..279
FT                   /note="Fascin"
FT                   /evidence="ECO:0000259|Pfam:PF06268"
SQ   SEQUENCE   618 AA;  68957 MW;  4F7CAB9402D5599E CRC64;
     MNNNEIYEDF NECLKIGILH IPSGRFLTAE VFNNEINISG TALRRRQVWS LITDRKNADT
     LFLQNSLGRF LSVNKDGKIS TSLKSDCEER FRLEFAPDGT GEWAFKSDAY GFYLTGSDTQ
     VSCFSKSPVW WSFRLATHPQ VHIRHQFRSR YLRLLNDGLE LRADQPYPWG PESVIWIEQP
     TVVASQGFGR GPNIPLVGKA AVSRLGRVSF RMPNGKYLKS NGEMCNEMDD STLFSFEYRP
     GNPGTFAFRD QTGHYLTTIG PGTAKVKTNT NIGKEELFLI EHVALQVGIV AHNGKFASVK
     QGIEISANQH ELDETAIFQL EYIGGMGFNA LEAIASSPAS TQLSGSDGGV SDSSASNTSL
     INNNHSITNG VHSDVYFLTT GFWRLRSRSG KLWKLSSSSG VKNTSSDGDR ESLFEMLTVN
     KINDKQIRQI VFRSNDGKQS LTARKLGAVS TSGRLIDETQ LPSSDELFNI ILTNRTSIVF
     LSSLTGGFLV RGKQNILDSN GVAYEPFYIR VTKRHTYKFF ARNPNSTYSI WAASLDGTLQ
     LEPTHQTPTD DENNEDTINN DLKYEFQLHF LGHSRVLIQS LNNQRGNSIS LVKSEIKGDV
     KLDIPSGGDI TVNYIWEI
//