UniProt: C4QWD1

Database: UniProt
Entry: C4QWD1_KOMPG

LinkDB:  C4QWD1_KOMPG 
Original site:  C4QWD1_KOMPG

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Ontology (4)   
   GO (4)   
Gene (2)   
   KEGG GENES (1)   
   NCBI-Gene (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (18)   
   InterPro (10)   
   Pfam (5)   
   PROSITE (2)   
   SMART (1)   
Literature (1)   
   PubMed (1)   
All databases (27)   

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ID   C4QWD1_KOMPG            Unreviewed;      4950 AA.
AC   C4QWD1;
DT   07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   07-JUL-2009, sequence version 1.
DT   27-MAR-2024, entry version 87.
DE   RecName: Full=Midasin {ECO:0000256|ARBA:ARBA00017143, ECO:0000256|PIRNR:PIRNR010340};
GN   OrderedLocusNames=PAS_chr1-1_0187 {ECO:0000313|EMBL:CAY67554.1};
OS   Komagataella phaffii (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Phaffomycetaceae; Komagataella.
OX   NCBI_TaxID=644223 {ECO:0000313|EMBL:CAY67554.1, ECO:0000313|Proteomes:UP000000314};
RN   [1] {ECO:0000313|EMBL:CAY67554.1, ECO:0000313|Proteomes:UP000000314}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GS115 / ATCC 20864 {ECO:0000313|Proteomes:UP000000314};
RX   PubMed=19465926; DOI=10.1038/nbt.1544;
RA   De Schutter K., Lin Y.C., Tiels P., Van Hecke A., Glinka S.,
RA   Weber-Lehmann J., Rouze P., Van de Peer Y., Callewaert N.;
RT   "Genome sequence of the recombinant protein production host Pichia
RT   pastoris.";
RL   Nat. Biotechnol. 27:561-566(2009).
CC   -!- FUNCTION: Nuclear chaperone required for maturation and nuclear export
CC       of pre-60S ribosome subunits. {ECO:0000256|PIRNR:PIRNR010340}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000256|ARBA:ARBA00004604}. Nucleus, nucleoplasm
CC       {ECO:0000256|ARBA:ARBA00004642}.
CC   -!- SIMILARITY: Belongs to the midasin family.
CC       {ECO:0000256|ARBA:ARBA00007188, ECO:0000256|PIRNR:PIRNR010340}.
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DR   EMBL; FN392319; CAY67554.1; -; Genomic_DNA.
DR   RefSeq; XP_002489835.1; XM_002489790.1.
DR   SMR; C4QWD1; -.
DR   STRING; 644223.C4QWD1; -.
DR   EnsemblFungi; CAY67554; CAY67554; PAS_chr1-1_0187.
DR   GeneID; 8197921; -.
DR   KEGG; ppa:PAS_chr1-1_0187; -.
DR   eggNOG; KOG1808; Eukaryota.
DR   HOGENOM; CLU_000050_0_2_1; -.
DR   InParanoid; C4QWD1; -.
DR   OMA; ILEQWHR; -.
DR   OrthoDB; 1221059at2759; -.
DR   Proteomes; UP000000314; Chromosome 1.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   CDD; cd00009; AAA; 3.
DR   CDD; cd01460; vWA_midasin; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 6.
DR   Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR040848; AAA_lid_7.
DR   InterPro; IPR011704; ATPase_dyneun-rel_AAA.
DR   InterPro; IPR048617; MDN1_AAA_lid_4.
DR   InterPro; IPR012099; Midasin.
DR   InterPro; IPR041190; Midasin_AAA_lid_5.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR025662; Sigma_54_int_dom_ATP-bd_1.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR48103:SF2; MIDASIN; 1.
DR   PANTHER; PTHR48103; MIDASIN-RELATED; 1.
DR   Pfam; PF07728; AAA_5; 8.
DR   Pfam; PF17865; AAA_lid_5; 1.
DR   Pfam; PF17867; AAA_lid_7; 3.
DR   Pfam; PF21108; MDN1_4th; 1.
DR   Pfam; PF00092; VWA; 1.
DR   PIRSF; PIRSF010340; Midasin; 1.
DR   SMART; SM00382; AAA; 6.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 6.
DR   SUPFAM; SSF53300; vWA-like; 1.
DR   PROSITE; PS00675; SIGMA54_INTERACT_1; 1.
DR   PROSITE; PS50234; VWFA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR010340};
KW   Chaperone {ECO:0000256|ARBA:ARBA00023186, ECO:0000256|PIRNR:PIRNR010340};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|PIRNR:PIRNR010340};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR010340};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000314}.
FT   DOMAIN          4745..4939
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
FT   REGION          746..765
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          4064..4594
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          3771..3798
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        4113..4133
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        4141..4173
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        4174..4205
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        4213..4232
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        4233..4269
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        4280..4319
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        4326..4357
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        4390..4435
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        4499..4529
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        4530..4547
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        4564..4578
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   4950 AA;  559559 MW;  EC3C2674C4FB4ADE CRC64;
     MDNPIRLDLQ DSLNKFKEYF NKLDLPLPAP FLLENESVPQ TLNTLAMLSL NDALTLPLLY
     GFKPIYIDII GRLLSNQELE NSFRTSRKRN IPGSDVLATS ARVIQLLDGV TVLIDSFLNK
     HNPLNFISNQ QISQEELQTI LIAFHRLLVH DTHRFKKHID PVILYQSLEN QSTNEVNRYL
     LIQLLSSVLN FSEQVVDEMM ISFNVQEAKG SLEGDIDVSF RFLSILEANR LSRFTSIPEP
     EFKDGSFIVQ QTHLSSNITS VGGILIPYSH VSKLNQVPDL VPIQKSLTAL KNMAINVQQG
     SPFMIVGKPG SGKSFLVNEL AKQLNMDTSK DIIKVHLNEQ TDSKMLLGTY TSGTTPGSFV
     WKDGILTTAV KQGKWILVED IDKAPTEVLS ILLSLLEKKE LTIPSRGEVI TATTGFQIIS
     TIRQPANSSI IPDIIGMRLW KIVLLPQLET EDLSSILTHK FPTVNRFLPQ IINCFLRCTE
     IFSTRGFITM NKGHQLRILS LTDLVKLCSR TERLLALAGI TSSDDLIADD VYDSIFQEAV
     DCFCSSIPEL PALEYIISEI GLCLNIPSSK ITLLLSKYVP VYQDLGDSLK IGRAHLSKTK
     TISMYKNNNS GSSSFAKTNH ALRLMEQISV AVSMAEPVLL VGETGTGKTT VVQHIAKQLN
     KKIVAINVSQ QTEVGDLLGG YKPVNTKLLA IPIQETFEEL FYASFSVKKN ARFLKLLAKC
     FNKSQWKNVF KLWKEAHKMA KSLFDENTSS DDESGPTKKR KLNSTESRQL MDKWNLFLEQ
     VSEFEKTSNQ TENSFVFQFI EGTLVKAVRN GYWLLLDEIN LASPETLECI SDLLSTQTDD
     RNIVLAEKGS ITPIKAHPDF RLFGNMNPGN DVGKKNLPAN FRSRWTELWV HSPDSDISDL
     LMIIDKYVGK YSLADEWVGN DIAQFYLEAK KLAEDNKLVD GANQKPHFSI RTLTRSLIYV
     TDIVSIYGLR RSLYEAFCMS FLTLLDADSE KILRPLVIKY TISRVKNFRK LITQCPPNPS
     DVNNPDEYVQ FRHYWMKHGP GEVRPQPHYI ITPFVEKNML NLVRATSIRR FPVLIQGPTS
     SGKTSMIKYL ANITGHKFVR INNHEHTDLQ EYLGSYVSDD NGKLAFKEGV LVEALRKGYW
     IVLDELNLAP TDVLEALNRL LDDNRELFIP ETQEFVTPHP DFMLFATQNP PGIYGGRKVL
     SRAFRNRFLE LHYDDIPQDE LEIILKERCQ IAPSYATKIV QVYQQLSLQR QSTRLFEQKN
     SFATLRDLFR WAEREAIGYE QLAANGYMLL AERVRRQEEK LVVKETLETV MKVRLDMDQY
     YKELENPKIL QMETPIVWTK AMRRLAVLVS TALKNHEPIL LVGETGCGKT SICQLLAELL
     RKELIIVNAH QNTETGDLLG AQRPIRNRSE LQTKVSKNIT DLFNEAGISY HESATLQDLL
     DIFDSINKFE GISEERIKSV EAQRASLNIL FEWTDGPLVQ AMKNGEFFLL DEISLADDSV
     LERLNSVLEP EKTLLLAEKG AENSFIQADK GFEFLATMNP GGDYGKKELS PALRNRFTEI
     FVPSMDDLED VHRIVASKLI EEASQYVEAI VKFSEYYALK VGNGNRTNGV ISLRDILAWV
     NFINTTVRKR NVSPEAALIH GCCLTFIDAL GTNNTASFSE NPDSLAKMKL SFVKTISELS
     GMNLLPYYEE EVSVELLEDR VKFGQFYLPR VPLTQESVSF NLKAPTTAKN AMRVTRALQV
     HKPILLEGSP GVGKTSLVTA LAKVTGNLLT RINLSEQTDL LDLFGSDAPA EGGQTGEFVW
     RDAPFLRAMK KGEWVLLDEM NLASQSVLEG LNACLDHRGE AYIPELDKTF PCHPNFVVFA
     AQNPQYQGGG RKGLPKSFIN RFTVVYVEML SEQDLNLISQ HLYPKIDPEI SAKLIKFISS
     LESEIVLNRT WGSEGGPWEF NLRDTLRWLQ LYSEPTVSTT VTPGDYLDIV IGQRFRNEKD
     RTQVKKLFTS VFGEKPKRPS FFALSKTFVE SGRIVSRRRD LIHSVPNQKL YSLQCNYPIL
     ESLLICINHA WPVILTGATD SGKSAVIQYA AGLIGSNVHQ FSMNSDIDSM DILGGYEQVD
     LMRGVSSICN SINSLLLDLV AVSLKDRSVS TSVASNILSL LQAISSNTVN TDNFNVFVQD
     LSTVAAVIAS PEFDELIQEC ILFEKKIQDT KTVKFEWFDG LLVKAVEQGD WLILDNANLC
     NASVLDRLNS LLEPNGVLVV NESSSVNGEP RIIVPHKNFR LFITTNPKYG ELSRAMRNRC
     IEIFLPSLEV RASKYDRTLL GDEYSKEYNQ AQTLEQEIAH LEISKANSVP ISKFVNLLNS
     ESMNFARLVD FIIQSSHQLI SPAVAFSLLQ LATTHSFEKL SDTICSSLWF SRNVKANCNK
     ISDYLSQFKL LGLMGNVFKI YDSAIVPALN DKDAIDYQKT QYLNPTVNPF LLDSISRIYP
     YVDSVEANLI YVVGSFLVQA ERTLSTLVSR SITKKLNDLN YLERSAAVNN GREVRNAPPI
     NIFKFLKDIQ IFLTNSFIEA ASSLFSTSDF YTDIFELQVI WIQLYELVQK QDEAKIRVFQ
     QLVTSWFQKC SGNPVVSSLA KDSTSDLNEF NSSLALTRGF SIEKIWESFR TTYPSSEVSW
     SSYEAVCKLS KDFDSIAQEQ FSENANMVQQ LRLLLIELHS DSFNLDIESE DFDEMQKKLT
     EGIEKFQEVS SGFINKRKHT YRSLFQSLLA MSKLPVTKDD AGPEFFRIAH EANMSTELLF
     KALSEDDLKP FPRLFHFLWT DETGAKSHVS KLFTDELFRE ILTCSFTLTE TEGKDVAQNL
     VDFSLLTQSL IKQSPSILEH KFSVVASLLR KWTFSIILSH TSKNSSEYQF VQSISTAPSL
     SEDDISKVAQ IYSGFEHQEA QVFTEFIHPV LIALNSTLDS GSLGKAFVSF ALGTIQLYVP
     SSPHDPAITD HVIYDLYHEQ LKLVSSICES LDTAAHVSGF DVNAFSEKNR VSIESSLVPS
     KPQVYRPKCS IDALFEDWNS FVDSSAATHP VQRLVQSLED SMELFSKKVD MFQRNASQFL
     DRLQRNHSRY ADLNDILAGY IYSLKFGFDL LNVHASVPSA PLDVLAPIDA TVLSSATDIV
     SFFDPINSYL KNRPLNESDV ESVYVFFMKI YFSHADEALD DVLIKSFQGL YYRWSLFNIK
     KKEEESLTNG VFKYAAPEFD GEEEYKTMFP DYEEVVDYQE KVNTDVSKDD VYYEVASAYI
     EGFAGKRSDL NSLISEGSKI SQLLNLGLNH SAGDISSSKL ASLAVLVSNS LNEFNKPAQF
     DNFYFGFSSS QTKLADSVIQ KLQYSILPLL KQWPEHAVLQ QIHSLCDDLL SFPVKTPIAQ
     LLQKVEHIYV AVAEWEKYAH SKISLKAHNA DVINLVVSWR KLELSSWQSI FEDEDKKIEK
     NIGKWWFHLF ELTILPIIKE EYVDLFSIVT ALNVFLSQTT LGEFELRVRL IEAFANHANM
     MAPQSKLAST LNNMVTFYEQ FLPNIRDQLA VKRRELEKKV KEMIILTSFK DVNVHALQQS
     SRHSHAKLFR IVKKYRELLA VGVSGVIESG LSANTKVVLN APVFSKKPFD RVIFEKAAQE
     CLKIPSYNRR PEILKGTVVL DRVSSLIQTA DEYGSFTLYE YAKEILQEME RLKKQTPNEA
     TEENKKIVGQ LKSQKRKLLS DTLKEVRRLG LKLHVTPNVS KELASVNQIL SDATSFRKLE
     IAGTDGYFFR VLDLFPRLRA SVAEMNEEVP VSDGQKALAA VENLMYHVLR SRNSLNALVN
     AKNEISSYQK EFQDMSSLDV INPASPCSAS SFLASKSAIK SCFEWIPKIL NFASTVLQSS
     TALTGLKSVD VFGSFGNEFE KFQLHNKNLL TTEEISTVNL FNKKVDELHE RLLLWKRENP
     LLAFVADLVI HCITSKKNIR LDTSDSFTTT DLDTLQHLFS DLTKSLIVVF QKFMDLYKVP
     IVEDDDGSFK STYQNVSKEV KLLHSSAILG KIRLLFEKLQ SIGATDFKFA TALNANICPL
     LTQYYNLILT LLNKQQELYV KNSHALFILT NCVYTLTKEG FCSPQSPDQT NDPGNMQDGT
     GLGDGDGATN SKDIDDDEDF SEQAQEANKE KDDNNDDEAE DKEDDAVDIE GDMAGDLEES
     KEKDNDDEDN ENSEDDEDKE MDEELDDIDD LDPNAVDEKM WEDEAQEDSK EKDSDKMPDN
     SKNDDDNMEA MEEDTKDNQN RENPNKQDEN DSLEDKDEQE DNAQNEGEEQ EEEEEEDVGE
     QEDEVKNDDG EKLDDFVPDV ETLELPDDLQ LEGEDDKDDT ENDNESQPDD AFDDPMNMDV
     ELEENNHKDG DEEEEEEEEE EDDEENGSED EGNDEVEAPS MSEEKAEEEA QEEGDENMGE
     DKNQNIDEDP ALDSETELNP IKDEEEQEET NDPAKEEEAV EGLDGVDEEG GQQDNIDDDA
     AVKQEAGISS EGAEAAASEE RDDMGASGGA AETQAQDEIE ENADNTQDPS SNEAKESLKQ
     LGDSLKEYHR RRQEIKEAND VDDSTEQNTH NQPDEYQHLN GENTELETQA LGAADKDQIQ
     TIDDNMAIDD EETMTENLDT EQEQNPDKEN DTASAEDIDD HAADGNQDME GDNRKATIGE
     RKINDFELGE LMEFSDNETE DEADKNEIEE LNVLDMANED DAAPRTLDEA RDLWRHSDLA
     TQDLAANLCE QLRLILEPTV ATKLRGDYKT GKRLNMKRII PYIASQFRKD KIWLRRTKPS
     KRQHQIMIAV DDSKSMSESK SVELAFHSIA LVAKALTQLE SGSLSVVRFG EDTKVVHPFN
     RPFTPESGAH VFQWFDFQQT KTDIQKMCSQ TLKLFNEVKA DADDLWQLQI ILSDGVCEDH
     ATVQRLVRRA REDKIMLVFV VIDGINSNES ILDMSQVQYV PDANGNMQLK VERYLDTFPF
     EFYVVVHNIN ELPEMLSLIL RQFFSEIAGM
//

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