ID C4QY62_KOMPG Unreviewed; 254 AA.
AC C4QY62;
DT 07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 07-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Essential protein with similarity to phosducins, which are G-protein regulators {ECO:0000313|EMBL:CAY68185.1};
GN OrderedLocusNames=PAS_chr1-4_0342 {ECO:0000313|EMBL:CAY68185.1};
OS Komagataella phaffii (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Phaffomycetaceae; Komagataella.
OX NCBI_TaxID=644223 {ECO:0000313|EMBL:CAY68185.1, ECO:0000313|Proteomes:UP000000314};
RN [1] {ECO:0000313|EMBL:CAY68185.1, ECO:0000313|Proteomes:UP000000314}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GS115 / ATCC 20864 {ECO:0000313|Proteomes:UP000000314};
RX PubMed=19465926; DOI=10.1038/nbt.1544;
RA De Schutter K., Lin Y.C., Tiels P., Van Hecke A., Glinka S.,
RA Weber-Lehmann J., Rouze P., Van de Peer Y., Callewaert N.;
RT "Genome sequence of the recombinant protein production host Pichia
RT pastoris.";
RL Nat. Biotechnol. 27:561-566(2009).
CC -!- SIMILARITY: Belongs to the phosducin family.
CC {ECO:0000256|ARBA:ARBA00009686}.
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DR EMBL; FN392319; CAY68185.1; -; Genomic_DNA.
DR RefSeq; XP_002490466.1; XM_002490421.1.
DR AlphaFoldDB; C4QY62; -.
DR SMR; C4QY62; -.
DR STRING; 644223.C4QY62; -.
DR EnsemblFungi; CAY68185; CAY68185; PAS_chr1-4_0342.
DR GeneID; 8197791; -.
DR KEGG; ppa:PAS_chr1-4_0342; -.
DR eggNOG; KOG3170; Eukaryota.
DR HOGENOM; CLU_072604_1_0_1; -.
DR InParanoid; C4QY62; -.
DR OMA; FCEIRAN; -.
DR OrthoDB; 313477at2759; -.
DR Proteomes; UP000000314; Chromosome 1.
DR GO; GO:0005737; C:cytoplasm; IEA:EnsemblFungi.
DR GO; GO:0003779; F:actin binding; IEA:EnsemblFungi.
DR GO; GO:0031683; F:G-protein beta/gamma-subunit complex binding; IEA:EnsemblFungi.
DR GO; GO:0030036; P:actin cytoskeleton organization; IEA:EnsemblFungi.
DR GO; GO:1903645; P:negative regulation of chaperone-mediated protein folding; IEA:EnsemblFungi.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:EnsemblFungi.
DR GO; GO:0006457; P:protein folding; IEA:EnsemblFungi.
DR GO; GO:0051726; P:regulation of cell cycle; IEA:EnsemblFungi.
DR CDD; cd02988; Phd_like_VIAF; 1.
DR Gene3D; 3.40.30.10; Glutaredoxin; 1.
DR InterPro; IPR024253; Phosducin_thioredoxin-like_dom.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR PANTHER; PTHR45809:SF3; PHOSDUCIN-LIKE PROTEIN 3; 1.
DR PANTHER; PTHR45809; VIRAL IAP-ASSOCIATED FACTOR HOMOLOG; 1.
DR Pfam; PF02114; Phosducin; 1.
DR SUPFAM; SSF52833; Thioredoxin-like; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000000314}.
FT DOMAIN 62..220
FT /note="Phosducin thioredoxin-like"
FT /evidence="ECO:0000259|Pfam:PF02114"
FT REGION 29..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 254 AA; 29254 MW; B418CC6525C99E04 CRC64;
MDPNNLKVQV EVDPTEDTEW NDILRSHGII PEKEPDPTEE LEKALSEAVE KQHANRLEHK
DLDELAALED EEDEEFLEEY KKKRMAEIQK LNDKSLFGSV YPISKPEYQK EVTETSKTAF
VFLHMTLQSA LQSRLLSALM VTLSSKFKEI KFCEIPANRA VENYPDGNCP TILIYHNGDV
VKQFITLTQL GGNDTKVEDL ERILVSIGAV DEHDRRLLIN NEDEESSENR KIRFQGKSIK
SKAYDSEEDD DFYD
//
