ID C4QYU5_KOMPG Unreviewed; 503 AA.
AC C4QYU5;
DT 07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 07-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 89.
DE SubName: Full=Mitochondrial protein, forms a heterodimer complex with Mto1p {ECO:0000313|EMBL:CAY68419.1};
GN OrderedLocusNames=PAS_chr1-4_0563 {ECO:0000313|EMBL:CAY68419.1};
OS Komagataella phaffii (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Phaffomycetaceae; Komagataella.
OX NCBI_TaxID=644223 {ECO:0000313|EMBL:CAY68419.1, ECO:0000313|Proteomes:UP000000314};
RN [1] {ECO:0000313|EMBL:CAY68419.1, ECO:0000313|Proteomes:UP000000314}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GS115 / ATCC 20864 {ECO:0000313|Proteomes:UP000000314};
RX PubMed=19465926; DOI=10.1038/nbt.1544;
RA De Schutter K., Lin Y.C., Tiels P., Van Hecke A., Glinka S.,
RA Weber-Lehmann J., Rouze P., Van de Peer Y., Callewaert N.;
RT "Genome sequence of the recombinant protein production host Pichia
RT pastoris.";
RL Nat. Biotechnol. 27:561-566(2009).
CC -!- SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like
CC GTPase superfamily. TrmE GTPase family. {ECO:0000256|ARBA:ARBA00011043,
CC ECO:0000256|RuleBase:RU003313}.
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DR EMBL; FN392319; CAY68419.1; -; Genomic_DNA.
DR RefSeq; XP_002490699.1; XM_002490654.1.
DR AlphaFoldDB; C4QYU5; -.
DR SMR; C4QYU5; -.
DR STRING; 644223.C4QYU5; -.
DR EnsemblFungi; CAY68419; CAY68419; PAS_chr1-4_0563.
DR GeneID; 8197694; -.
DR KEGG; ppa:PAS_chr1-4_0563; -.
DR eggNOG; KOG1191; Eukaryota.
DR HOGENOM; CLU_019624_3_1_1; -.
DR InParanoid; C4QYU5; -.
DR OMA; PYETSQM; -.
DR OrthoDB; 5478664at2759; -.
DR Proteomes; UP000000314; Chromosome 1.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:EnsemblFungi.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0070899; P:mitochondrial tRNA wobble uridine modification; IEA:EnsemblFungi.
DR CDD; cd04164; trmE; 1.
DR CDD; cd14858; TrmE_N; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.20.120.430; tRNA modification GTPase MnmE domain 2; 1.
DR HAMAP; MF_00379; GTPase_MnmE; 1.
DR InterPro; IPR031168; G_TrmE.
DR InterPro; IPR006073; GTP-bd.
DR InterPro; IPR018948; GTP-bd_TrmE_N.
DR InterPro; IPR004520; GTPase_MnmE.
DR InterPro; IPR027368; MnmE_dom2.
DR InterPro; IPR025867; MnmE_helical.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR027266; TrmE/GcvT_dom1.
DR NCBIfam; TIGR00450; mnmE_trmE_thdF; 1.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR42714; TRNA MODIFICATION GTPASE GTPBP3; 1.
DR PANTHER; PTHR42714:SF2; TRNA MODIFICATION GTPASE GTPBP3, MITOCHONDRIAL; 1.
DR Pfam; PF01926; MMR_HSR1; 1.
DR Pfam; PF12631; MnmE_helical; 1.
DR Pfam; PF10396; TrmE_N; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134, ECO:0000256|RuleBase:RU003313};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU003313};
KW Reference proteome {ECO:0000313|Proteomes:UP000000314};
KW tRNA processing {ECO:0000256|ARBA:ARBA00022694,
KW ECO:0000256|RuleBase:RU003313}.
FT DOMAIN 26..150
FT /note="GTP-binding protein TrmE N-terminal"
FT /evidence="ECO:0000259|Pfam:PF10396"
FT DOMAIN 153..500
FT /note="MnmE helical"
FT /evidence="ECO:0000259|Pfam:PF12631"
FT DOMAIN 253..373
FT /note="G"
FT /evidence="ECO:0000259|Pfam:PF01926"
SQ SEQUENCE 503 AA; 55906 MW; 0439209B51D5F193 CRC64;
MKPRWNPQLR CPRVLKRWVS DVRLPTIYAL STKQGRSAIA VIRISGPSTL DVFKRLSRID
DDKRLQRHRL ASVRKLYDPK SGVLLDEALS LFFKGPNSYT GEDVLELHVH GGNAVVKCVL
NAIKYLHESA APIRYADPGE FSRRGFQNGK FDLTEVEGVR DMIDAETEFQ RVSALTSLKG
ETRHLFHRWR TEIVKNVALL TTVIDFGEDH DIEEVNELFG RVAKNIDLLE AEIKNYLEKV
KRSEILMKGI KLSLIGPPNA GKSSLLNVLS DSDSVIVSDI PGTTRDSIDI PLDVGGYKVV
IGDTAGIRSF EDADIIEKEG IKRATTKSLN SDVAVIILPV DLREINSDLI KHIENLKSST
SSCSENILVA LNKSDLLEDP NQHSQIIKQF SEALKLPEST FCLISCANRD GIDSLMGTLI
ERFKIITLTT NSDPISISQR SQDILSNDVL HGFQEFRSYN GIDDVLATES LRYSVEGIGK
ITGEAVGIEE ILGVVFSSFC IGK
//
