ID C4QZH4_KOMPG Unreviewed; 747 AA.
AC C4QZH4;
DT 07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 07-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 80.
DE SubName: Full=Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to u {ECO:0000313|EMBL:CAY68648.1};
GN OrderedLocusNames=PAS_chr2-1_0048 {ECO:0000313|EMBL:CAY68648.1};
OS Komagataella phaffii (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Phaffomycetaceae; Komagataella.
OX NCBI_TaxID=644223 {ECO:0000313|EMBL:CAY68648.1, ECO:0000313|Proteomes:UP000000314};
RN [1] {ECO:0000313|EMBL:CAY68648.1, ECO:0000313|Proteomes:UP000000314}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GS115 / ATCC 20864 {ECO:0000313|Proteomes:UP000000314};
RX PubMed=19465926; DOI=10.1038/nbt.1544;
RA De Schutter K., Lin Y.C., Tiels P., Van Hecke A., Glinka S.,
RA Weber-Lehmann J., Rouze P., Van de Peer Y., Callewaert N.;
RT "Genome sequence of the recombinant protein production host Pichia
RT pastoris.";
RL Nat. Biotechnol. 27:561-566(2009).
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ferric reductase (FRE) family.
CC {ECO:0000256|ARBA:ARBA00006278}.
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DR EMBL; FN392320; CAY68648.1; -; Genomic_DNA.
DR RefSeq; XP_002490928.1; XM_002490883.1.
DR AlphaFoldDB; C4QZH4; -.
DR SMR; C4QZH4; -.
DR EnsemblFungi; CAY68648; CAY68648; PAS_chr2-1_0048.
DR GeneID; 8198167; -.
DR KEGG; ppa:PAS_chr2-1_0048; -.
DR eggNOG; KOG0039; Eukaryota.
DR HOGENOM; CLU_010365_4_0_1; -.
DR InParanoid; C4QZH4; -.
DR OMA; HLARIMF; -.
DR OrthoDB; 2477110at2759; -.
DR Proteomes; UP000000314; Chromosome 2.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000293; F:ferric-chelate reductase activity; IEA:UniProt.
DR GO; GO:0000041; P:transition metal ion transport; IEA:UniProt.
DR CDD; cd06186; NOX_Duox_like_FAD_NADP; 1.
DR Gene3D; 3.40.50.80; Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module; 1.
DR InterPro; IPR013112; FAD-bd_8.
DR InterPro; IPR017927; FAD-bd_FR_type.
DR InterPro; IPR013130; Fe3_Rdtase_TM_dom.
DR InterPro; IPR013121; Fe_red_NAD-bd_6.
DR InterPro; IPR039261; FNR_nucleotide-bd.
DR PANTHER; PTHR32361; FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT; 1.
DR PANTHER; PTHR32361:SF25; FERRIC_CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT 1; 1.
DR Pfam; PF08022; FAD_binding_8; 1.
DR Pfam; PF01794; Ferric_reduct; 1.
DR Pfam; PF08030; NAD_binding_6; 1.
DR SFLD; SFLDS00052; Ferric_Reductase_Domain; 1.
DR SFLD; SFLDG01168; Ferric_reductase_subgroup_(FRE; 1.
DR SUPFAM; SSF52343; Ferredoxin reductase-like, C-terminal NADP-linked domain; 1.
DR PROSITE; PS51384; FAD_FR; 1.
PE 3: Inferred from homology;
KW Electron transport {ECO:0000256|ARBA:ARBA00022982};
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000000314};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..747
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5009950828"
FT TRANSMEM 164..186
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 234..254
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 274..292
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 313..333
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 353..369
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 376..396
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 426..541
FT /note="FAD-binding FR-type"
FT /evidence="ECO:0000259|PROSITE:PS51384"
SQ SEQUENCE 747 AA; 85372 MW; 652A4490177DA49C CRC64;
MLITSLLVLI LFNVLATAKI FAKPSSLMFS CLTASQEFQY DFVPPPDVIP FWYIACNYEP
ALGSIVFCMD SNADSICPFS NSLEVLALGC QTQGDRTLTQ TYLMESGKNA TKYMKNPASD
PDFNFTQLTT PIMFNMSEVV NKKDAYYNFF DNLDDSTKFG DFTIIYWGVL LILIGLFNHI
SAHNYLKSIS LNSRLNQWKA LVVLPTLSSY HLNPARFRGI AFFEALLPLR QETFVLIAYI
LLCVYYTTSN YKVIANSPLF GSPYRQYLRF ISDRTGIFAF TQLPLLILFG GRNNILMTIS
GLPFNTFIIF HKWISRVMML CAVVHAHQFV IYLEATGTFR RSLGELYFQF GELALLCCLL
IMVQSVFYFR KRCYELFLVL HIFLAFIFLV GCYFHVSKIG YSEWILATLG LWILDRVWRF
VNIYRYGVQT AQLTVFHPHS TDSNREDPTV KVSIPKPATW KSYPGCFVYL YFLDPHLKFW
ESHPFTIYDS TDQFGDPTPM INIYIKPKCG TTKAIYDQIM SRDITGVKVL VEGPYGHRAH
TENYDQLLLF VGGNGIPGPF SHAARSVSAL PYKDVESFKK VELVWSIKTL SALNWFYDEL
IQLKDTNVSV TVYVTRGDLS LADDDNSSTS SNNNIEPEIL TETSHLLKDD TNNKSKKREV
SSIITIAEKF HNLSKFVTFI RGRPNFEKKL DQVINECSQA SKITTIGLVA CGPSLMCDNI
RNLVAHRLSR NDTGKFRIDL LEELQVW
//
