ID C4QZU6_KOMPG Unreviewed; 989 AA.
AC C4QZU6;
DT 07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 07-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE RecName: Full=HECT-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012485};
DE EC=2.3.2.26 {ECO:0000256|ARBA:ARBA00012485};
GN OrderedLocusNames=PAS_chr2-1_0164 {ECO:0000313|EMBL:CAY68770.1};
OS Komagataella phaffii (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Phaffomycetaceae; Komagataella.
OX NCBI_TaxID=644223 {ECO:0000313|EMBL:CAY68770.1, ECO:0000313|Proteomes:UP000000314};
RN [1] {ECO:0000313|EMBL:CAY68770.1, ECO:0000313|Proteomes:UP000000314}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GS115 / ATCC 20864 {ECO:0000313|Proteomes:UP000000314};
RX PubMed=19465926; DOI=10.1038/nbt.1544;
RA De Schutter K., Lin Y.C., Tiels P., Van Hecke A., Glinka S.,
RA Weber-Lehmann J., Rouze P., Van de Peer Y., Callewaert N.;
RT "Genome sequence of the recombinant protein production host Pichia
RT pastoris.";
RL Nat. Biotechnol. 27:561-566(2009).
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DR EMBL; FN392320; CAY68770.1; -; Genomic_DNA.
DR RefSeq; XP_002491050.1; XM_002491005.1.
DR AlphaFoldDB; C4QZU6; -.
DR SMR; C4QZU6; -.
DR STRING; 644223.C4QZU6; -.
DR EnsemblFungi; CAY68770; CAY68770; PAS_chr2-1_0164.
DR GeneID; 8198547; -.
DR KEGG; ppa:PAS_chr2-1_0164; -.
DR eggNOG; KOG0942; Eukaryota.
DR HOGENOM; CLU_002173_2_3_1; -.
DR InParanoid; C4QZU6; -.
DR OrthoDB; 1386at2759; -.
DR Proteomes; UP000000314; Chromosome 2.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:InterPro.
DR GO; GO:0000209; P:protein polyubiquitination; IEA:InterPro.
DR CDD; cd00078; HECTc; 1.
DR Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR InterPro; IPR044611; E3A/B/C-like.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR PANTHER; PTHR45700; UBIQUITIN-PROTEIN LIGASE E3C; 1.
DR PANTHER; PTHR45700:SF2; UBIQUITIN-PROTEIN LIGASE E3C; 1.
DR Pfam; PF00632; HECT; 1.
DR SMART; SM00119; HECTc; 1.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR PROSITE; PS50237; HECT; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000000314};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104}.
FT DOMAIN 633..989
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT ACT_SITE 957
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ SEQUENCE 989 AA; 114249 MW; C3B835F86EF821DE CRC64;
MFNFDGSTKR RNVNLSGRRN NLESREQLLH RAELERNRRK EAKLQDKSVR IIQSYIRTFL
LRSHISLEFE KIWLHCGSDV TALNMFAFFC PNLVLKRDEA WLQVQLDHVS KLLLSSHGSI
SFLLRNALVE VLFKTSKQGR SPLPMLKLVN SLSHEFAIEW IQRKDLMEKL VDRLGENEEL
DLQVLKFTFN FRHNDMETFA MAFINIVQKA NLNDEAKQLI REQFSRPSSF YLQLPNSLFF
LYLLSVITIW KKYGGVENLD IFLAQELSSA VEKMQELKFC FENELSQDLS LNRDADLDGR
KKLIITTGSK EALLYLYSPD YQTKISNLPN VSTEFLSNFY YSLLVPIDTG SPQNEEILNS
LLISVVVNGL PHGILHYWLQ QIVSSDIFRM EDGNWELNKP ILTGCSVELW QTLHIFLDVY
FYVLNMSSDS VIFDQDRGRL PRDEFLKVVS FLKGLCITLV LKDKELKPSL PSSTRVMYDK
TLVVALKLLH QIYLRNLRLS FVSEEYWLCD LSLSIEQIVP VLYERDISIS NNADFDLDPD
TSEHLNLESD FSQLYGLNST RYMKLPSSVL AALKVLKFLP FMFSFTTRAT ILHQLIRQSQ
EIRDTYGGMN RIQGTISRDN IIEDGFALLS KLTGEQLKNY LGIQFTNQFG AEAGIDGGGL
TKEFLTETVK KGFATTNESG VEDLMLFKHS PRNEIYPNPA LYLKRTKGVD VHKDLEMIRY
LGSIVGKCLY EKILVDLPFS PFFLTRWSVN QPYKTMFDDL KYYDEDLFRN LNKLLSLNSD
QVDALELNFT LTERFYYNGA FKTTTIMLLP NGANIPVTTA NRLQYVFAVS NFKLYTSLRL
QTDYFLQGLF KVIPSQWLEV FNPMELQILV SGRDRGIDIS DLRKNTVFSE YTENDQTIID
LFDILEHDFS NEERSKFIRF VTSSSKAPLL GFSQLNPKFG VRNIGPFSDR LPSAFTCFNQ
LKLPDYGNRK VLKEKLLYAI SSESGFDLS
//
