ID C4R0J1_KOMPG Unreviewed; 568 AA.
AC C4R0J1;
DT 07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 07-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 91.
DE RecName: Full=B-related factor 1 {ECO:0000256|ARBA:ARBA00031009};
GN OrderedLocusNames=PAS_chr2-1_0394 {ECO:0000313|EMBL:CAY69015.1};
OS Komagataella phaffii (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Phaffomycetaceae; Komagataella.
OX NCBI_TaxID=644223 {ECO:0000313|EMBL:CAY69015.1, ECO:0000313|Proteomes:UP000000314};
RN [1] {ECO:0000313|EMBL:CAY69015.1, ECO:0000313|Proteomes:UP000000314}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GS115 / ATCC 20864 {ECO:0000313|Proteomes:UP000000314};
RX PubMed=19465926; DOI=10.1038/nbt.1544;
RA De Schutter K., Lin Y.C., Tiels P., Van Hecke A., Glinka S.,
RA Weber-Lehmann J., Rouze P., Van de Peer Y., Callewaert N.;
RT "Genome sequence of the recombinant protein production host Pichia
RT pastoris.";
RL Nat. Biotechnol. 27:561-566(2009).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the TFIIB family.
CC {ECO:0000256|ARBA:ARBA00010857}.
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DR EMBL; FN392320; CAY69015.1; -; Genomic_DNA.
DR RefSeq; XP_002491295.1; XM_002491250.1.
DR AlphaFoldDB; C4R0J1; -.
DR SMR; C4R0J1; -.
DR STRING; 644223.C4R0J1; -.
DR EnsemblFungi; CAY69015; CAY69015; PAS_chr2-1_0394.
DR GeneID; 8198862; -.
DR KEGG; ppa:PAS_chr2-1_0394; -.
DR eggNOG; KOG1598; Eukaryota.
DR HOGENOM; CLU_010293_3_3_1; -.
DR InParanoid; C4R0J1; -.
DR OMA; AEPPCKV; -.
DR OrthoDB; 5483352at2759; -.
DR Proteomes; UP000000314; Chromosome 2.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000126; C:transcription factor TFIIIB complex; IEA:EnsemblFungi.
DR GO; GO:0000994; F:RNA polymerase III core binding; IEA:EnsemblFungi.
DR GO; GO:0000995; F:RNA polymerase III general transcription initiation factor activity; IEA:EnsemblFungi.
DR GO; GO:0001006; F:RNA polymerase III type 3 promoter sequence-specific DNA binding; IEA:EnsemblFungi.
DR GO; GO:0017025; F:TBP-class protein binding; IEA:EnsemblFungi.
DR GO; GO:0001156; F:TFIIIC-class transcription factor complex binding; IEA:EnsemblFungi.
DR GO; GO:0001112; P:DNA-templated transcription open complex formation; IEA:EnsemblFungi.
DR GO; GO:0006359; P:regulation of transcription by RNA polymerase III; IEA:EnsemblFungi.
DR GO; GO:0070898; P:RNA polymerase III preinitiation complex assembly; IEA:EnsemblFungi.
DR CDD; cd20553; CYCLIN_TFIIIB90_rpt1; 1.
DR CDD; cd20554; CYCLIN_TFIIIB90_rpt2; 1.
DR Gene3D; 1.10.472.10; Cyclin-like; 2.
DR Gene3D; 1.20.5.650; Single helix bin; 1.
DR InterPro; IPR011665; BRF1_TBP-bd_dom.
DR InterPro; IPR013763; Cyclin-like_dom.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR000812; TFIIB.
DR InterPro; IPR023486; TFIIB_CS.
DR InterPro; IPR013150; TFIIB_cyclin.
DR InterPro; IPR013137; Znf_TFIIB.
DR PANTHER; PTHR11618:SF4; TRANSCRIPTION FACTOR IIIB 90 KDA SUBUNIT; 1.
DR PANTHER; PTHR11618; TRANSCRIPTION INITIATION FACTOR IIB-RELATED; 1.
DR Pfam; PF07741; BRF1; 1.
DR Pfam; PF08271; TF_Zn_Ribbon; 1.
DR Pfam; PF00382; TFIIB; 2.
DR PRINTS; PR00685; TIFACTORIIB.
DR SMART; SM00385; CYCLIN; 2.
DR SUPFAM; SSF47954; Cyclin-like; 2.
DR SUPFAM; SSF57783; Zinc beta-ribbon; 1.
DR PROSITE; PS00782; TFIIB; 2.
DR PROSITE; PS51134; ZF_TFIIB; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00469};
KW Reference proteome {ECO:0000313|Proteomes:UP000000314};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00469};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00469}.
FT DOMAIN 5..38
FT /note="TFIIB-type"
FT /evidence="ECO:0000259|PROSITE:PS51134"
FT REGION 355..396
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 372..389
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 568 AA; 63477 MW; 2B522861B48D715B CRC64;
MATLNKPRCK NCGGTEFTRD INTPASDLAC VECGTVSEEN PIVSEVSFGE TASGAATVQG
AFVGSDQARA NFGNNRGSLD SREQTLNKGK RRIKTVAAVL GIADYISDAA YLWFRLALTN
NFVQGRRSQN VVAACLYIAC RKVKTHHMLI DFSSRLQISV YSVGATFLKM VKTLHISNLP
LADPSLFIQH FAEQLNFGNS KIKVIKDAVK LAHRMADDWI HEGRRPAGIA GACLMLAARM
NNFRRTHLEI AAVAKIGEST IQKRLNEFKN TNASKLSIDE FRKATNIEST APPSYTSNRI
KEKAIQQMIN HNNKYSEEKE TVMNFILKDS EISSEEIRTY ILKIQKQQRE DLKRKVNQVV
SPSPGEVGEI QRSIDEDEDD DDESEDESDK DGNTANSIYN SFERQQQDQA RLIELNRPKN
LHKLPTTGDL LGKIKSDPEN LEDVDDEELE GFLLTEDESR IKERVWVGLN HDFLIEQEKR
RLKEESDKLA GHTTIKRRRK KNIDDDGLGI PKTELTEFAS GLDPAALGLQ SSINSIGEGS
SALSSAKSML QKKSYSKKLN YAAVENLF
//
