ID C4R2Z7_KOMPG Unreviewed; 319 AA.
AC C4R2Z7;
DT 07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 07-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE RecName: Full=GDT1 family protein {ECO:0000256|RuleBase:RU365102};
GN OrderedLocusNames=PAS_chr2-2_0062 {ECO:0000313|EMBL:CAY69871.1};
OS Komagataella phaffii (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Phaffomycetaceae; Komagataella.
OX NCBI_TaxID=644223 {ECO:0000313|EMBL:CAY69871.1, ECO:0000313|Proteomes:UP000000314};
RN [1] {ECO:0000313|EMBL:CAY69871.1, ECO:0000313|Proteomes:UP000000314}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GS115 / ATCC 20864 {ECO:0000313|Proteomes:UP000000314};
RX PubMed=19465926; DOI=10.1038/nbt.1544;
RA De Schutter K., Lin Y.C., Tiels P., Van Hecke A., Glinka S.,
RA Weber-Lehmann J., Rouze P., Van de Peer Y., Callewaert N.;
RT "Genome sequence of the recombinant protein production host Pichia
RT pastoris.";
RL Nat. Biotechnol. 27:561-566(2009).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU365102}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU365102}.
CC -!- SIMILARITY: Belongs to the GDT1 family. {ECO:0000256|ARBA:ARBA00009190,
CC ECO:0000256|RuleBase:RU365102}.
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DR EMBL; FN392320; CAY69871.1; -; Genomic_DNA.
DR RefSeq; XP_002492151.1; XM_002492106.1.
DR AlphaFoldDB; C4R2Z7; -.
DR STRING; 644223.C4R2Z7; -.
DR EnsemblFungi; CAY69871; CAY69871; PAS_chr2-2_0062.
DR GeneID; 8199167; -.
DR KEGG; ppa:PAS_chr2-2_0062; -.
DR eggNOG; KOG2881; Eukaryota.
DR HOGENOM; CLU_040186_0_0_1; -.
DR InParanoid; C4R2Z7; -.
DR OMA; KSQLVCM; -.
DR OrthoDB; 180756at2759; -.
DR Proteomes; UP000000314; Chromosome 2.
DR GO; GO:0005801; C:cis-Golgi network; IEA:EnsemblFungi.
DR GO; GO:0000324; C:fungal-type vacuole; IEA:EnsemblFungi.
DR GO; GO:0005797; C:Golgi medial cisterna; IEA:EnsemblFungi.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015369; F:calcium:proton antiporter activity; IEA:EnsemblFungi.
DR GO; GO:0010486; F:manganese:proton antiporter activity; IEA:EnsemblFungi.
DR GO; GO:0032468; P:Golgi calcium ion homeostasis; IEA:EnsemblFungi.
DR GO; GO:0030026; P:intracellular manganese ion homeostasis; IEA:EnsemblFungi.
DR InterPro; IPR001727; GDT1-like.
DR InterPro; IPR049555; GDT1-like_CS.
DR PANTHER; PTHR12608:SF1; TRANSMEMBRANE PROTEIN 165; 1.
DR PANTHER; PTHR12608; TRANSMEMBRANE PROTEIN HTP-1 RELATED; 1.
DR Pfam; PF01169; UPF0016; 2.
DR PROSITE; PS01214; UPF0016; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU365102};
KW Reference proteome {ECO:0000313|Proteomes:UP000000314};
KW Signal {ECO:0000256|RuleBase:RU365102};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU365102};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU365102}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|RuleBase:RU365102"
FT CHAIN 21..319
FT /note="GDT1 family protein"
FT /evidence="ECO:0000256|RuleBase:RU365102"
FT /id="PRO_5017495615"
FT TRANSMEM 85..108
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365102"
FT TRANSMEM 115..139
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365102"
FT TRANSMEM 226..244
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365102"
FT TRANSMEM 264..285
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365102"
FT TRANSMEM 297..315
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365102"
SQ SEQUENCE 319 AA; 34510 MW; E3984992E2517A19 CRC64;
MKFGLGSLGL AVALIPIASA LYRVDDYETY VPTTVGPHPT GAIEPAEDQV DIKVEPTVYS
QLLDEFENVL GESDGMVNHD NLASIWMSFS MIVVSEIGDK TFLIAALMAM RSPRWLVFAG
ASSALVVMTV LSCIVGHILP TLLTEKTTKT LASILFVVFG IKLAKEGFET PKDVGVEEEL
AEVEEEIALS SINNKLDDAE TGSVSGSNKK KYQTTLSHLL EETKELLSFI LSPTFLQVFT
MTFLGEWGDR SQIATIAMAA SAQFYFVIVG SVLGHALCTG IAVLGGKLLA GHISLRAVNL
GGSLAFFIFA FIYLYEIYM
//
