ID C4R3S2_KOMPG Unreviewed; 392 AA.
AC C4R3S2;
DT 07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 07-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 78.
DE SubName: Full=TFIIE large subunit {ECO:0000313|EMBL:CAY70153.1};
GN OrderedLocusNames=PAS_chr3_0178 {ECO:0000313|EMBL:CAY70153.1};
OS Komagataella phaffii (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Phaffomycetaceae; Komagataella.
OX NCBI_TaxID=644223 {ECO:0000313|EMBL:CAY70153.1, ECO:0000313|Proteomes:UP000000314};
RN [1] {ECO:0000313|EMBL:CAY70153.1, ECO:0000313|Proteomes:UP000000314}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GS115 / ATCC 20864 {ECO:0000313|Proteomes:UP000000314};
RX PubMed=19465926; DOI=10.1038/nbt.1544;
RA De Schutter K., Lin Y.C., Tiels P., Van Hecke A., Glinka S.,
RA Weber-Lehmann J., Rouze P., Van de Peer Y., Callewaert N.;
RT "Genome sequence of the recombinant protein production host Pichia
RT pastoris.";
RL Nat. Biotechnol. 27:561-566(2009).
CC -!- SIMILARITY: Belongs to the TFIIE alpha subunit family.
CC {ECO:0000256|ARBA:ARBA00008947}.
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DR EMBL; FN392321; CAY70153.1; -; Genomic_DNA.
DR RefSeq; XP_002492387.1; XM_002492342.1.
DR AlphaFoldDB; C4R3S2; -.
DR SMR; C4R3S2; -.
DR STRING; 644223.C4R3S2; -.
DR EnsemblFungi; CAY70153; CAY70153; PAS_chr3_0178.
DR GeneID; 8199452; -.
DR KEGG; ppa:PAS_chr3_0178; -.
DR eggNOG; KOG2593; Eukaryota.
DR HOGENOM; CLU_035744_2_0_1; -.
DR InParanoid; C4R3S2; -.
DR OMA; DAIKWKV; -.
DR OrthoDB; 7984at2759; -.
DR Proteomes; UP000000314; Chromosome 3.
DR GO; GO:0005673; C:transcription factor TFIIE complex; IEA:EnsemblFungi.
DR GO; GO:0097550; C:transcription preinitiation complex; IEA:EnsemblFungi.
DR GO; GO:0000993; F:RNA polymerase II complex binding; IEA:EnsemblFungi.
DR GO; GO:0003697; F:single-stranded DNA binding; IEA:EnsemblFungi.
DR GO; GO:0001097; F:TFIIH-class transcription factor complex binding; IEA:EnsemblFungi.
DR GO; GO:0001113; P:transcription open complex formation at RNA polymerase II promoter; IEA:EnsemblFungi.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR039997; TFE.
DR InterPro; IPR017919; TFIIE/TFIIEa_HTH.
DR InterPro; IPR002853; TFIIE_asu.
DR InterPro; IPR024550; TFIIEa/SarR/Rpc3_HTH_dom.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR13097:SF7; GENERAL TRANSCRIPTION FACTOR IIE, POLYPEPTIDE 1, ALPHA; 1.
DR PANTHER; PTHR13097; TRANSCRIPTION INITIATION FACTOR IIE, ALPHA SUBUNIT; 1.
DR Pfam; PF02002; TFIIE_alpha; 1.
DR SMART; SM00531; TFIIE; 1.
DR SUPFAM; SSF57783; Zinc beta-ribbon; 1.
DR PROSITE; PS51344; HTH_TFE_IIE; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000000314};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 6..96
FT /note="HTH TFE/IIEalpha-type"
FT /evidence="ECO:0000259|PROSITE:PS51344"
FT REGION 251..288
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 351..392
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 253..273
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 274..288
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 357..392
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 392 AA; 44345 MW; 3F3D32B37CE466A1 CRC64;
MDYELATSLI RFVVRGFYTK HYVLVVEALL MHWVLSEDDL IYLLGMQRKG LRALCNRLVE
DRLISAQHQK EENLHQRMTT RTYYYIRFVD AIDAIKWKMH SVVKSLKDQM AHDSDPQGYV
CPRCRKRYSQ LDALSMVSDN KLNFVCDICN GVLIEDDSGI QAKRRQEKLT QLMGELDPII
GYLKRIDEGH VVDNTFETSL TRAVPAQSST VSAAESGSYA LRAGQESKRE LSQSLKNATA
RSQAVLHVDI TTSDENQTRE EKVKAEKQEK LKQNALPSWH SESTVGKGTL GKLGTQDIAS
EILEKEVSAD DHVVEGKDQV QEIPKVETTG TNLEDIEAQD ALAAYYAQLA EKQAKEDADD
DAEDGDEDED FDIDDDEFED ILETGNNDEQ DQ
//
