ID C4R4F2_KOMPG Unreviewed; 646 AA.
AC C4R4F2;
DT 07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 07-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 81.
DE RecName: Full=Translation initiation factor eIF2B subunit epsilon {ECO:0000256|ARBA:ARBA00044144};
DE AltName: Full=eIF2B GDP-GTP exchange factor subunit epsilon {ECO:0000256|ARBA:ARBA00044345};
GN OrderedLocusNames=PAS_chr3_0391 {ECO:0000313|EMBL:CAY70438.1};
OS Komagataella phaffii (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Phaffomycetaceae; Komagataella.
OX NCBI_TaxID=644223 {ECO:0000313|EMBL:CAY70438.1, ECO:0000313|Proteomes:UP000000314};
RN [1] {ECO:0000313|EMBL:CAY70438.1, ECO:0000313|Proteomes:UP000000314}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GS115 / ATCC 20864 {ECO:0000313|Proteomes:UP000000314};
RX PubMed=19465926; DOI=10.1038/nbt.1544;
RA De Schutter K., Lin Y.C., Tiels P., Van Hecke A., Glinka S.,
RA Weber-Lehmann J., Rouze P., Van de Peer Y., Callewaert N.;
RT "Genome sequence of the recombinant protein production host Pichia
RT pastoris.";
RL Nat. Biotechnol. 27:561-566(2009).
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}.
CC -!- SIMILARITY: Belongs to the eIF-2B gamma/epsilon subunits family.
CC {ECO:0000256|ARBA:ARBA00007878}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FN392321; CAY70438.1; -; Genomic_DNA.
DR RefSeq; XP_002492617.1; XM_002492572.1.
DR AlphaFoldDB; C4R4F2; -.
DR SMR; C4R4F2; -.
DR STRING; 644223.C4R4F2; -.
DR EnsemblFungi; CAY70438; CAY70438; PAS_chr3_0391.
DR GeneID; 8200218; -.
DR KEGG; ppa:PAS_chr3_0391; -.
DR eggNOG; KOG1461; Eukaryota.
DR HOGENOM; CLU_012507_1_0_1; -.
DR InParanoid; C4R4F2; -.
DR OMA; LAQSCKI; -.
DR OrthoDB; 5474157at2759; -.
DR Proteomes; UP000000314; Chromosome 3.
DR GO; GO:0005851; C:eukaryotic translation initiation factor 2B complex; IEA:EnsemblFungi.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:EnsemblFungi.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0031369; F:translation initiation factor binding; IEA:InterPro.
DR GO; GO:0002183; P:cytoplasmic translational initiation; IEA:EnsemblFungi.
DR CDD; cd04197; eIF-2B_epsilon_N; 1.
DR CDD; cd11558; W2_eIF2B_epsilon; 1.
DR Gene3D; 1.25.40.180; -; 1.
DR Gene3D; 2.160.10.10; Hexapeptide repeat proteins; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR035543; eIF-2B_epsilon_N.
DR InterPro; IPR005835; NTP_transferase_dom.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR InterPro; IPR011004; Trimer_LpxA-like_sf.
DR InterPro; IPR003307; W2_domain.
DR InterPro; IPR044123; W2_eIF2B_epsilon.
DR PANTHER; PTHR45887; TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON; 1.
DR PANTHER; PTHR45887:SF1; TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON; 1.
DR Pfam; PF00483; NTP_transferase; 1.
DR Pfam; PF02020; W2; 1.
DR SMART; SM00515; eIF5C; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
DR SUPFAM; SSF51161; Trimeric LpxA-like enzymes; 1.
DR PROSITE; PS51363; W2; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Initiation factor {ECO:0000313|EMBL:CAY70438.1};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000000314}.
FT DOMAIN 474..646
FT /note="W2"
FT /evidence="ECO:0000259|PROSITE:PS51363"
SQ SEQUENCE 646 AA; 72603 MW; B1D708E8BAED0A39 CRC64;
MPPKNKKQKE IVQDERLQAI ILTDSYQTRF EPVSSQSPRC LLPLANVPLI EYTLEFLANS
GVDEVYVMCR SHASQIQDYL EKSKWSQRNS PFKVQTVLSL ESRSVGDAMR DLDNRGLITG
DFVLISGDVV TNMSLEPVLK THRQRRSQDK DHMLTMVLME ASPYHRSRSN TEPATFMVDR
ATGKCLYYEQ IGGAKKAVSI DPELLTGIDK FEIRNDLVDC HVDICAPQVP LIFQENFDYQ
ELRNDFVRGI LASDILQKTV YAHITNQYAA RVESWSTYHA ISQDIMERWT YPVAPESNVI
DGTSYIHVGE HIYKENDVIL AQTSRLQRCV VIGGGSFVGA ETNIVCSCVG KNVRIGEGVQ
LKNSYIWDDV VLENGVEATG AVVASGAIIR AGAKLLPGAI VGFNEEVPAG AEVAASESKM
PQLKFSESAA HDDGLFDLSD TSITSLPGTG SRRKGRTLST TSYYSEFDSD ADGLRDEDDF
DKEAMATVTR SMENNHDLDT ALLELNTLRM SMNVSYHELR LATTKALLAR IEHFVATQTL
SLTEATNKIF RKWGLLFRRQ VFETEEQIDL LNVLQQQCLE LENRSDAASI LMRALYILYD
EDIVEEDQIY AWWDAPESNA SEELIEVKAP AGKWVQWLRE AEEESD
//
