ID   C4R522_KOMPG            Unreviewed;       548 AA.
AC   C4R522;
DT   07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   07-JUL-2009, sequence version 1.
DT   27-MAR-2024, entry version 83.
DE   RecName: Full=Importin subunit alpha {ECO:0000256|PIRNR:PIRNR005673};
GN   OrderedLocusNames=PAS_chr3_0612 {ECO:0000313|EMBL:CAY70658.1};
OS   Komagataella phaffii (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Phaffomycetaceae; Komagataella.
OX   NCBI_TaxID=644223 {ECO:0000313|EMBL:CAY70658.1, ECO:0000313|Proteomes:UP000000314};
RN   [1] {ECO:0000313|EMBL:CAY70658.1, ECO:0000313|Proteomes:UP000000314}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GS115 / ATCC 20864 {ECO:0000313|Proteomes:UP000000314};
RX   PubMed=19465926; DOI=10.1038/nbt.1544;
RA   De Schutter K., Lin Y.C., Tiels P., Van Hecke A., Glinka S.,
RA   Weber-Lehmann J., Rouze P., Van de Peer Y., Callewaert N.;
RT   "Genome sequence of the recombinant protein production host Pichia
RT   pastoris.";
RL   Nat. Biotechnol. 27:561-566(2009).
CC   -!- SIMILARITY: Belongs to the importin alpha family.
CC       {ECO:0000256|ARBA:ARBA00010394, ECO:0000256|PIRNR:PIRNR005673}.
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DR   EMBL; FN392321; CAY70658.1; -; Genomic_DNA.
DR   RefSeq; XP_002492837.1; XM_002492792.1.
DR   AlphaFoldDB; C4R522; -.
DR   SMR; C4R522; -.
DR   STRING; 644223.C4R522; -.
DR   EnsemblFungi; CAY70658; CAY70658; PAS_chr3_0612.
DR   GeneID; 8199814; -.
DR   KEGG; ppa:PAS_chr3_0612; -.
DR   eggNOG; KOG0166; Eukaryota.
DR   HOGENOM; CLU_018084_6_0_1; -.
DR   InParanoid; C4R522; -.
DR   OMA; EMIQMLY; -.
DR   OrthoDB; 916229at2759; -.
DR   Proteomes; UP000000314; Chromosome 3.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0061608; F:nuclear import signal receptor activity; IEA:InterPro.
DR   GO; GO:0006606; P:protein import into nucleus; IEA:InterPro.
DR   Gene3D; 1.20.5.690; Importin-alpha, importin-beta-binding domain; 1.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR032413; Arm_3.
DR   InterPro; IPR000225; Armadillo.
DR   InterPro; IPR002652; Importin-a_IBB.
DR   InterPro; IPR036975; Importin-a_IBB_sf.
DR   InterPro; IPR024931; Importin_alpha.
DR   PANTHER; PTHR23316; IMPORTIN ALPHA; 1.
DR   PANTHER; PTHR23316:SF71; IMPORTIN SUBUNIT ALPHA; 1.
DR   Pfam; PF00514; Arm; 8.
DR   Pfam; PF16186; Arm_3; 1.
DR   Pfam; PF01749; IBB; 1.
DR   PIRSF; PIRSF005673; Importin_alpha; 1.
DR   SMART; SM00185; ARM; 8.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   PROSITE; PS50176; ARM_REPEAT; 3.
DR   PROSITE; PS51214; IBB; 1.
PE   3: Inferred from homology;
KW   Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW   ECO:0000256|PIRNR:PIRNR005673};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000314};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR005673}.
FT   DOMAIN          1..62
FT                   /note="IBB"
FT                   /evidence="ECO:0000259|PROSITE:PS51214"
FT   REPEAT          131..173
FT                   /note="ARM"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT   REPEAT          173..201
FT                   /note="ARM"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT   REPEAT          341..375
FT                   /note="ARM"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT   REGION          1..40
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          54..74
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   548 AA;  61216 MW;  5AC9DC8EF5563710 CRC64;
     MDSDTTSRFV PEYRRTNFKN KGRFQQDELR RRRETQQVEL RKAKRDETLA KRRFLVNPGE
     GSVPQEDDSE NEDEINVEDN QFYLELQKEL PRMMEKINSN DMESQVEATM KFRQILSREY
     NPPIELVIQS GVVPRLVEFM KDQQEILQLE AAWALTNIAS GSSDQTKVVI EAGAVPLFVQ
     LLKSPSIEVR EQAIWALGNV SGDSSAFRDY VLSCNVMGPV LELFNSSKIS LIRTATWTLS
     NLCRGKKPQP DWNVVSAALP TLAKLIYSTD IETLIDACWA ISYLSDGSSD AIQAVVDARI
     PRRLVELLGH ESTDVQTPAL RAVGNIVTGN DLQTQVVINA GVLPALLPLL DSPKETIKKE
     ACWTISNITA GNPDQIQAVI DCNLIPQIIR LLVTADYKTK KEACWAISNA SSGGLVRPDQ
     IRYLVSQGCI KPLCDLLAVA DNKIIEVTLD ALENILKMGE LDKEARGAPY NENAMYIEEA
     GGMEKIFDCQ NNENEKIYKK AYQMIEQYFG EDDGDLEDTG LQPEASGDAF TFGVNSADPS
     QQQSFNFN
//