ID C4R5I2_KOMPG Unreviewed; 974 AA.
AC C4R5I2;
DT 07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 07-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 81.
DE SubName: Full=Nuclear envelope protein that mediates the nuclear export of importin alpha (Srp1p) {ECO:0000313|EMBL:CAY70818.1};
GN OrderedLocusNames=PAS_chr3_0767 {ECO:0000313|EMBL:CAY70818.1};
OS Komagataella phaffii (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Phaffomycetaceae; Komagataella.
OX NCBI_TaxID=644223 {ECO:0000313|EMBL:CAY70818.1, ECO:0000313|Proteomes:UP000000314};
RN [1] {ECO:0000313|EMBL:CAY70818.1, ECO:0000313|Proteomes:UP000000314}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GS115 / ATCC 20864 {ECO:0000313|Proteomes:UP000000314};
RX PubMed=19465926; DOI=10.1038/nbt.1544;
RA De Schutter K., Lin Y.C., Tiels P., Van Hecke A., Glinka S.,
RA Weber-Lehmann J., Rouze P., Van de Peer Y., Callewaert N.;
RT "Genome sequence of the recombinant protein production host Pichia
RT pastoris.";
RL Nat. Biotechnol. 27:561-566(2009).
CC -!- SIMILARITY: Belongs to the XPO2/CSE1 family.
CC {ECO:0000256|ARBA:ARBA00008669}.
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DR EMBL; FN392321; CAY70818.1; -; Genomic_DNA.
DR RefSeq; XP_002492997.1; XM_002492952.1.
DR AlphaFoldDB; C4R5I2; -.
DR SMR; C4R5I2; -.
DR STRING; 644223.C4R5I2; -.
DR EnsemblFungi; CAY70818; CAY70818; PAS_chr3_0767.
DR GeneID; 8200460; -.
DR KEGG; ppa:PAS_chr3_0767; -.
DR eggNOG; KOG1992; Eukaryota.
DR HOGENOM; CLU_009614_0_0_1; -.
DR InParanoid; C4R5I2; -.
DR OMA; AENEFLM; -.
DR OrthoDB; 178772at2759; -.
DR Proteomes; UP000000314; Chromosome 3.
DR GO; GO:0034399; C:nuclear periphery; IEA:EnsemblFungi.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0051170; P:import into nucleus; IEA:UniProt.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR001494; Importin-beta_N.
DR InterPro; IPR005043; XPO2_C.
DR InterPro; IPR013713; XPO2_central.
DR PANTHER; PTHR10997:SF8; EXPORTIN-2; 1.
DR PANTHER; PTHR10997; IMPORTIN-7, 8, 11; 1.
DR Pfam; PF03378; CAS_CSE1; 1.
DR Pfam; PF08506; Cse1; 1.
DR Pfam; PF03810; IBN_N; 1.
DR SMART; SM00913; IBN_N; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50166; IMPORTIN_B_NT; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000000314}.
FT DOMAIN 20..93
FT /note="Importin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50166"
SQ SEQUENCE 974 AA; 110695 MW; F5B5FB7077DBABFF CRC64;
MSDIASILEK SLHHEYAKES EAQLAALENH EGFATEVLRV VSNEGYPMNI RLSGAVFFKN
FIRRKWLDED GNYKVSEVDV KMIKKEVIGL MIQLPPSLQA QIGEAVSIIA DSEFPQRWPE
LIDELVVRIG EDMLVNRGVL VVAHSIFKRW RPLFRSDELF LEIKLVLDKF SVPFLKLFKH
VDELVDQNVN SKEHLEVLLD VLLLLVKIYY DLNCQDIPEF FEDNLAAGMS LMHKYLLFNP
PVLKNDEEEE QADLLTKVKT AICELIQLYT IRYEDVFGKL IPDFMKCTWD LLIETDNKPK
NDLLVSKALT FMSSTARIPA QAGFYQDEEH LNKIITAIII PNIRIRQADE ELFEDDPIEF
IRLDLEGADS ESRKKSALEL LKELKEQNQS SVTSIGMKYV NQYLQEYLQS PSENWRSKDL
ALNLYSALAV KGTITSNGVT SINLLLNVVE FFTTTVATDL VNDQVNPILK VDAIKYIYTF
RNQLTKEQLI EAFQLLSTHL NNSEYVVYTY TAITLEKILS IKQHGKPLFQ KADIPTNVLQ
LLITNLFQLI TSKDSSPEKL AENEFLMICV MRILVVSEDA INHLSKEILT QLLRIIQSIA
KNPSNPKFTH YTFESIAAVA KYQKTIDDDL LELVVPQLLP ILAEDVQEFV PYIFQILAFL
LENYPSTKPL PTAYGQLIKP LMSPTVWEFK GNIPAVTRLL QAIIQQSPQS FATDADITPV
LGVFQKLIAS KVNDTYGFDL LETIFFNIDF TRLANYTKTA AMLLLQRLQN SKTEKFVKRF
VVMMATFASI SEKDQKLVRN ASLLGPDFVI QFVDSVQNGI FGQILTNFII PSSDGFNNLR
DRNVIVIGLT NLISTSSQFY SPEGKYRLQL IPLLDKLTHL VTTESISGYL RTEDELDTSE
NEEFLFGSSF NKLNSIPYIP FTPVLTLSLS SQDLIRQFFK ERLGQLNENC GGTLGQIFGS
LSVESQQGLA SMGI
//
