ID C4R5P8_KOMPG Unreviewed; 707 AA.
AC C4R5P8;
DT 07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 07-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=Transketolase, similar to Tkl2p {ECO:0000313|EMBL:CAY70884.1};
GN OrderedLocusNames=PAS_chr3_0832 {ECO:0000313|EMBL:CAY70884.1};
OS Komagataella phaffii (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Phaffomycetaceae; Komagataella.
OX NCBI_TaxID=644223 {ECO:0000313|EMBL:CAY70884.1, ECO:0000313|Proteomes:UP000000314};
RN [1] {ECO:0000313|EMBL:CAY70884.1, ECO:0000313|Proteomes:UP000000314}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GS115 / ATCC 20864 {ECO:0000313|Proteomes:UP000000314};
RX PubMed=19465926; DOI=10.1038/nbt.1544;
RA De Schutter K., Lin Y.C., Tiels P., Van Hecke A., Glinka S.,
RA Weber-Lehmann J., Rouze P., Van de Peer Y., Callewaert N.;
RT "Genome sequence of the recombinant protein production host Pichia
RT pastoris.";
RL Nat. Biotechnol. 27:561-566(2009).
CC -!- COFACTOR:
CC Name=Co(2+); Xref=ChEBI:CHEBI:48828;
CC Evidence={ECO:0000256|ARBA:ARBA00001941};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- COFACTOR:
CC Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC Evidence={ECO:0000256|ARBA:ARBA00001964};
CC -!- SIMILARITY: Belongs to the transketolase family.
CC {ECO:0000256|ARBA:ARBA00007131}.
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DR EMBL; FN392321; CAY70884.1; -; Genomic_DNA.
DR RefSeq; XP_002493063.1; XM_002493018.1.
DR AlphaFoldDB; C4R5P8; -.
DR SMR; C4R5P8; -.
DR STRING; 644223.C4R5P8; -.
DR EnsemblFungi; CAY70884; CAY70884; PAS_chr3_0832.
DR GeneID; 8199663; -.
DR KEGG; ppa:PAS_chr3_0832; -.
DR eggNOG; KOG0523; Eukaryota.
DR HOGENOM; CLU_009227_0_0_1; -.
DR InParanoid; C4R5P8; -.
DR OMA; FINIHTV; -.
DR OrthoDB; 5399939at2759; -.
DR Proteomes; UP000000314; Chromosome 3.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:1901135; P:carbohydrate derivative metabolic process; IEA:UniProt.
DR GO; GO:0006163; P:purine nucleotide metabolic process; IEA:UniProt.
DR CDD; cd07033; TPP_PYR_DXS_TK_like; 1.
DR CDD; cd02012; TPP_TK; 1.
DR Gene3D; 3.40.50.920; -; 1.
DR Gene3D; 3.40.50.970; -; 2.
DR InterPro; IPR029061; THDP-binding.
DR InterPro; IPR009014; Transketo_C/PFOR_II.
DR InterPro; IPR005475; Transketolase-like_Pyr-bd.
DR InterPro; IPR020826; Transketolase_BS.
DR InterPro; IPR033248; Transketolase_C.
DR InterPro; IPR049557; Transketolase_CS.
DR InterPro; IPR033247; Transketolase_fam.
DR InterPro; IPR005474; Transketolase_N.
DR PANTHER; PTHR43522; TRANSKETOLASE; 1.
DR PANTHER; PTHR43522:SF6; TRANSKETOLASE-LIKE PYRIMIDINE-BINDING DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR Pfam; PF02779; Transket_pyr; 1.
DR Pfam; PF02780; Transketolase_C; 1.
DR Pfam; PF00456; Transketolase_N; 1.
DR SMART; SM00861; Transket_pyr; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
DR SUPFAM; SSF52922; TK C-terminal domain-like; 1.
DR PROSITE; PS00801; TRANSKETOLASE_1; 1.
DR PROSITE; PS00802; TRANSKETOLASE_2; 1.
PE 3: Inferred from homology;
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000000314};
KW Thiamine pyrophosphate {ECO:0000256|ARBA:ARBA00023052};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 365..547
FT /note="Transketolase-like pyrimidine-binding"
FT /evidence="ECO:0000259|SMART:SM00861"
SQ SEQUENCE 707 AA; 78853 MW; 5B53831AB00D2500 CRC64;
MARIPKAVST QDDIHELVIK TFRCYVLDLV EQYGGGHPGS AMGMVAIGIA LWKYQMKYAP
NDPDYFNRDR FVLSNGHVCL FQYLFQHLTG LKEMTVKQLQ SYHSSDYHSL TPGHPEIENP
AVEVTTGPLG QGISNAVGMA IGSKNLAATY NRPGFPVVDN TIYAIVGDAC LQEGPALESI
SLAGHLALDN LIVIYDNNQV CCDGSVDVNN TEDISAKFRA QNWNVIDIVD GSRDVATIVK
AIDWAKAETE RPTLINVRTE IGQDSAFGNH HAAHGSALGE EGIRELKTKY GFNPAQKFWF
PKEVYDFFAE KPAKGDELVK NWKKLVDSYV KEYPREGQEF LSRVRGELPK NWRTYIPQDK
PTEPTATRTS AREIVRALGK NLPQVIAGSG DLSVSILLNW DGVKYFFNPK LQTFCGLGGD
YSGRYIEFGI REHSMCAIAN GLAAYNKGTF LPITSTFYMF YLYAAPALRM AALQELKAIH
IATHDSIGAG EDGPTHQPIA LSSLFRAMPN FYYMRPADAT EVAALFEVAV ELEHSTLLSL
SRHEVDQYPG KTSAQGAKRG GYVVEDCEGK PDVQLIGTGS ELEFAIKTAR LLRQQKGWKV
RVLSFPCQRL FDEQSITYRR SVLRRGEVPT VVVEAYVAYG WERYATAGYT MNTFGKSLPV
EDVYKYFGYT PEKIGERVVQ YVNSIKASPQ ILYEFHDLKG KPKHDKL
//
