ID C4R6L0_KOMPG Unreviewed; 364 AA.
AC C4R6L0;
DT 07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 07-JUL-2009, sequence version 1.
DT 28-JUN-2023, entry version 64.
DE SubName: Full=High affinity nicotinic acid plasma membrane permease {ECO:0000313|EMBL:CAY71235.1};
GN OrderedLocusNames=PAS_chr4_0006 {ECO:0000313|EMBL:CAY71235.1};
OS Komagataella phaffii (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Phaffomycetaceae; Komagataella.
OX NCBI_TaxID=644223 {ECO:0000313|EMBL:CAY71235.1, ECO:0000313|Proteomes:UP000000314};
RN [1] {ECO:0000313|EMBL:CAY71235.1, ECO:0000313|Proteomes:UP000000314}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GS115 / ATCC 20864 {ECO:0000313|Proteomes:UP000000314};
RX PubMed=19465926; DOI=10.1038/nbt.1544;
RA De Schutter K., Lin Y.C., Tiels P., Van Hecke A., Glinka S.,
RA Weber-Lehmann J., Rouze P., Van de Peer Y., Callewaert N.;
RT "Genome sequence of the recombinant protein production host Pichia
RT pastoris.";
RL Nat. Biotechnol. 27:561-566(2009).
CC -!- SIMILARITY: Belongs to the iron/ascorbate-dependent oxidoreductase
CC family. {ECO:0000256|RuleBase:RU003682}.
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DR EMBL; FN392322; CAY71235.1; -; Genomic_DNA.
DR RefSeq; XP_002493414.1; XM_002493369.1.
DR AlphaFoldDB; C4R6L0; -.
DR SMR; C4R6L0; -.
DR STRING; 644223.C4R6L0; -.
DR EnsemblFungi; CAY71235; CAY71235; PAS_chr4_0006.
DR GeneID; 8200533; -.
DR KEGG; ppa:PAS_chr4_0006; -.
DR eggNOG; KOG0143; Eukaryota.
DR HOGENOM; CLU_010119_10_0_1; -.
DR InParanoid; C4R6L0; -.
DR OMA; GEWKYVP; -.
DR OrthoDB; 1057251at2759; -.
DR Proteomes; UP000000314; Chromosome 4.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR GO; GO:0044283; P:small molecule biosynthetic process; IEA:UniProt.
DR InterPro; IPR026992; DIOX_N.
DR InterPro; IPR044861; IPNS-like_FE2OG_OXY.
DR InterPro; IPR027443; IPNS-like_sf.
DR InterPro; IPR005123; Oxoglu/Fe-dep_dioxygenase.
DR PANTHER; PTHR47990; 2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED; 1.
DR PANTHER; PTHR47990:SF39; 2OG-FE(II) OXYGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00800)-RELATED; 1.
DR Pfam; PF03171; 2OG-FeII_Oxy; 1.
DR Pfam; PF14226; DIOX_N; 1.
DR PRINTS; PR00682; IPNSYNTHASE.
DR SUPFAM; SSF51197; Clavaminate synthase-like; 1.
DR PROSITE; PS51471; FE2OG_OXY; 1.
PE 3: Inferred from homology;
KW Iron {ECO:0000256|RuleBase:RU003682};
KW Metal-binding {ECO:0000256|RuleBase:RU003682};
KW Oxidoreductase {ECO:0000256|RuleBase:RU003682};
KW Reference proteome {ECO:0000313|Proteomes:UP000000314}.
FT DOMAIN 190..299
FT /note="Fe2OG dioxygenase"
FT /evidence="ECO:0000259|PROSITE:PS51471"
SQ SEQUENCE 364 AA; 42458 MW; 7F1EA08590913735 CRC64;
MPISKRNVVQ PWSRPKPTKE VLDYSELVTI DFSKFDKPNG KFELAKDLAE ALQYDGFWVV
VNFGIPQDLI DRQFALGKHF FNNYSLEEKS AKACDFENGD YFGYKKVGAK TVFGTAVREN
VETFNMPKFT KDETYKELLK QPFYDDFYDE VSSFSRITHD LLVKRLYQLF AIILELDESY
FANKHDYDLP SDTHLRYMQY HPRSLEDDER VERIWSRAHT DFGSLTLLFN QEVNGLQLKL
SDNSWKYVKP VYGGVICNIG DTLNFWSGGY FKSTIHRVVR PPEDQLDEPR VGLFYFDRPG
KTADIEVAPS PLLKRLGLYN KVEPVNGHHY VRQRVKNYHE SSDYGKRAGE VFQVGQFKIQ
DGFD
//
