ID C4R6W0_KOMPG Unreviewed; 1133 AA.
AC C4R6W0;
DT 07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 07-JUL-2009, sequence version 1.
DT 13-SEP-2023, entry version 77.
DE SubName: Full=Component of the condensin complex, essential SMC chromosomal ATPase family member {ECO:0000313|EMBL:CAY71335.1};
GN OrderedLocusNames=PAS_chr4_0109 {ECO:0000313|EMBL:CAY71335.1};
OS Komagataella phaffii (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Phaffomycetaceae; Komagataella.
OX NCBI_TaxID=644223 {ECO:0000313|EMBL:CAY71335.1, ECO:0000313|Proteomes:UP000000314};
RN [1] {ECO:0000313|EMBL:CAY71335.1, ECO:0000313|Proteomes:UP000000314}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GS115 / ATCC 20864 {ECO:0000313|Proteomes:UP000000314};
RX PubMed=19465926; DOI=10.1038/nbt.1544;
RA De Schutter K., Lin Y.C., Tiels P., Van Hecke A., Glinka S.,
RA Weber-Lehmann J., Rouze P., Van de Peer Y., Callewaert N.;
RT "Genome sequence of the recombinant protein production host Pichia
RT pastoris.";
RL Nat. Biotechnol. 27:561-566(2009).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the SMC family. SMC2 subfamily.
CC {ECO:0000256|ARBA:ARBA00005231}.
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DR EMBL; FN392322; CAY71335.1; -; Genomic_DNA.
DR RefSeq; XP_002493514.1; XM_002493469.1.
DR AlphaFoldDB; C4R6W0; -.
DR SMR; C4R6W0; -.
DR STRING; 644223.C4R6W0; -.
DR EnsemblFungi; CAY71335; CAY71335; PAS_chr4_0109.
DR GeneID; 8201196; -.
DR KEGG; ppa:PAS_chr4_0109; -.
DR eggNOG; KOG0933; Eukaryota.
DR HOGENOM; CLU_001042_9_0_1; -.
DR InParanoid; C4R6W0; -.
DR OMA; HNKIAME; -.
DR OrthoDB; 231904at2759; -.
DR Proteomes; UP000000314; Chromosome 4.
DR GO; GO:0034506; C:chromosome, centromeric core domain; IEA:EnsemblFungi.
DR GO; GO:0000796; C:condensin complex; IEA:EnsemblFungi.
DR GO; GO:0005737; C:cytoplasm; IEA:EnsemblFungi.
DR GO; GO:0000791; C:euchromatin; IEA:EnsemblFungi.
DR GO; GO:0000776; C:kinetochore; IEA:EnsemblFungi.
DR GO; GO:0005730; C:nucleolus; IEA:EnsemblFungi.
DR GO; GO:0005524; F:ATP binding; IEA:EnsemblFungi.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:EnsemblFungi.
DR GO; GO:0003682; F:chromatin binding; IEA:EnsemblFungi.
DR GO; GO:1990814; F:DNA/DNA annealing activity; IEA:EnsemblFungi.
DR GO; GO:0003690; F:double-stranded DNA binding; IEA:EnsemblFungi.
DR GO; GO:0003680; F:minor groove of adenine-thymine-rich DNA binding; IEA:EnsemblFungi.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0036292; P:DNA rewinding; IEA:EnsemblFungi.
DR GO; GO:0007076; P:mitotic chromosome condensation; IEA:EnsemblFungi.
DR GO; GO:1903342; P:negative regulation of meiotic DNA double-strand break formation; IEA:EnsemblFungi.
DR GO; GO:0070550; P:rDNA chromatin condensation; IEA:EnsemblFungi.
DR GO; GO:0070058; P:tRNA gene clustering; IEA:EnsemblFungi.
DR CDD; cd03273; ABC_SMC2_euk; 1.
DR Gene3D; 1.20.1060.20; -; 1.
DR Gene3D; 1.10.287.950; Methyl-accepting chemotaxis protein; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR003395; RecF/RecN/SMC_N.
DR InterPro; IPR024704; SMC.
DR InterPro; IPR027120; Smc2_ABC.
DR InterPro; IPR010935; SMC_hinge.
DR InterPro; IPR036277; SMC_hinge_sf.
DR PANTHER; PTHR43977:SF2; STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN; 1.
DR PANTHER; PTHR43977; STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3; 1.
DR Pfam; PF06470; SMC_hinge; 1.
DR Pfam; PF02463; SMC_N; 2.
DR PIRSF; PIRSF005719; SMC; 2.
DR SMART; SM00968; SMC_hinge; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF75553; Smc hinge domain; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00022776};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW DNA condensation {ECO:0000256|ARBA:ARBA00023067};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW Reference proteome {ECO:0000313|Proteomes:UP000000314}.
FT DOMAIN 521..639
FT /note="SMC hinge"
FT /evidence="ECO:0000259|SMART:SM00968"
FT COILED 253..287
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 333..367
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 431..503
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 641..671
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 709..778
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 812..902
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 953..990
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1133 AA; 128891 MW; CE00DE5E17AC75B4 CRC64;
MKVEELIIDG FKSYATRTVI SGWDSQFNAI TGLNGSGKSN ILDAICFVLG ISSMTTVRAS
NLQDLIYKRG QAGVTKASVT IVFDNSDTDK SPIGFEKLPS ISVTRQIVLG GTSKYLINGH
RAQQQTVLQL FQSVQLNINN PNFLIMQGKI TKVLNMKPTE ILSLIEEAAG TKMYEDRREK
AEKTMSKKDV KLREIRSLLE EEITPKLDKL ANERRVFLEF QQIQTDLEKL TRVVAAHDYK
DSSKKYDHQR RLLDKQKGLL GELESSIEQL EKESKSIHEE INRIKEKRKT ELSNNASVKE
LEKQETIISN ELARLVTSHQ IKLDTIKSTN SLKQKHKSQI KQMETTIEKL KEKTTLLEKE
YQNSKDSLTK LKQNHSKRED LLSSLSTGIS SQGISTTGYA SQLRDAKKKH SDALLSQEQL
NMQSLHLQKE IETEKTAVLE AEKENKVLTD ELERKGQEYC TITQKLNELG FHPSNITNLQ
QQKSKIEQQI YKATNELENS KRRVANLDFH FANPSPQFDR RSVKGTVAQL FTVDEKNMKS
VSALEVCAGG KLYNVVVDTQ ETASQLLKGG QLKKRVTFIP LNKISAYCID PRKVQQAKEL
CPGKVELALN LITYDKDVEA AMKFTFGGRL VCGSRNNVGV MLTTVQKCKN IEREIANMKK
ELLEMNEKQK QQQGIVKQTE SLQQKANKLK HEISLGKKNQ ESHHSTITIR KNAQNISQLE
EINEKLNNQN TIVLKLTEEI AQIEKDIQEF GSDKSSKLKQ LADEVKSLAS QIPKAEETMN
LKYSDYQQSL LDLEKMKGDL DDLNSGVQEK DVSQLNAECD EIKQQMTNQE QELDKVRGKL
EDERQKLLNL NDELDDLNNE LSTKHKLINE NKLETQKLSH EIEKVKSVCK AYKQTVENLI
KENEWVSDSN IVEKLIEENP SINVHECYER IDQLKGVFQG MKRKVNSNIM SIIENVEKKE
GSLKQMIRTI EKDKAKIEET INKLNEYKKI TLIETWKKVS EDFGNIFRDL LPNSFAKLVP
PENKDVTDGL EVKVMLGKVW KESLVELSGG QRSLIALSLI LALLQFKPAP MYILDEVDAA
LDLSHTQNIG HLIKTRFKGS QFIVVSLKEG MFTNANRVFR TRFQDGTSVV SAT
//
