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Database: UniProt
Entry: C4R845_KOMPG
LinkDB: C4R845_KOMPG
Original site: C4R845_KOMPG 
ID   C4R845_KOMPG            Unreviewed;       519 AA.
AC   C4R845;
DT   07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   07-JUL-2009, sequence version 1.
DT   16-JAN-2019, entry version 52.
DE   SubName: Full=Purine-cytosine permease {ECO:0000313|EMBL:CAY71770.1};
GN   OrderedLocusNames=PAS_chr4_0514 {ECO:0000313|EMBL:CAY71770.1};
OS   Komagataella phaffii (strain GS115 / ATCC 20864) (Yeast) (Pichia
OS   pastoris).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Phaffomycetaceae; Komagataella.
OX   NCBI_TaxID=644223 {ECO:0000313|EMBL:CAY71770.1, ECO:0000313|Proteomes:UP000000314};
RN   [1] {ECO:0000313|EMBL:CAY71770.1, ECO:0000313|Proteomes:UP000000314}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GS115 / ATCC 20864 {ECO:0000313|Proteomes:UP000000314};
RX   PubMed=19465926; DOI=10.1038/nbt.1544;
RA   De Schutter K., Lin Y.-C., Tiels P., Van Hecke A., Glinka S.,
RA   Weber-Lehmann J., Rouze P., Van de Peer Y., Callewaert N.;
RT   "Genome sequence of the recombinant protein production host Pichia
RT   pastoris.";
RL   Nat. Biotechnol. 27:561-566(2009).
CC   -!- SIMILARITY: Belongs to the purine-cytosine permease (2.A.39)
CC       family. {ECO:0000256|PIRNR:PIRNR002744}.
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DR   EMBL; FN392322; CAY71770.1; -; Genomic_DNA.
DR   RefSeq; XP_002493949.1; XM_002493904.1.
DR   STRING; 644223.XP_002493949.1; -.
DR   EnsemblFungi; CAY71770; CAY71770; PAS_chr4_0514.
DR   GeneID; 8201003; -.
DR   KEGG; ppa:PAS_chr4_0514; -.
DR   eggNOG; ENOG410IHV6; Eukaryota.
DR   eggNOG; COG1457; LUCA.
DR   HOGENOM; HOG000162981; -.
DR   InParanoid; C4R845; -.
DR   OMA; ASWQIAF; -.
DR   Proteomes; UP000000314; Chromosome 4.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.10.4160.10; -; 1.
DR   InterPro; IPR001248; Pur-cyt_permease.
DR   InterPro; IPR026030; Pur-cyt_permease_Fcy2/21/22.
DR   InterPro; IPR038271; Pur-cyt_permease_sf.
DR   PANTHER; PTHR31806; PTHR31806; 1.
DR   Pfam; PF02133; Transp_cyt_pur; 1.
DR   PIRSF; PIRSF002744; Pur-cyt_permease; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000314};
KW   Membrane {ECO:0000256|PIRNR:PIRNR002744, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000314};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|PIRNR:PIRNR002744}.
FT   TRANSMEM     77     98       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    104    130       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    151    177       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    183    207       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    219    238       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    250    274       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    286    311       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    340    359       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    380    400       Helical. {ECO:0000256|SAM:Phobius}.
SQ   SEQUENCE   519 AA;  57157 MW;  651F33C678D29C27 CRC64;
     MSAYKTDIEK ADAGSSDKNS TYQVKTEDFQ VDESVAEVSK GKFAWYENFT LMMKAETRGI
     EIVPEEEKTR TSLWEAASMW FSANLVIGTF ALGAISQTVF ALDFWSSVLC IIFFNMLGVF
     PVAFFSVFGV KFGLRQMILT RFLSGDLAMR LFAAINCICC VGWGAVNIMA AAQLLHIVNN
     KTLPPWAACL IFVVLTILVT FFGYDVIHAY EKWSWIPNMF VFIVIIARMS ISGNFTFGTM
     AGGPTVAGNV LSFGGAIFGY ASGWATFAAD YTVYMRTDTP PLKIFAWVYF GLFTPLCFTM
     MLGTACATGI FSDESWATLY YDNGVGGLVY AVLVENSLHG FGQFCCVLLA LSTVANNIPN
     MYSIGLSAQA VTSKARRVPR IVWTLCGNSV TLAISIPAYY HFERFMSNFM NIIGYNLAIY
     DTVCLSEHFI WKRGFSSKYD VMLEQWHDKT AAPPGYAGLI GFGCGAAGVV LGMNQVWYSG
     AIGRLIGDFG GDVGFELGAG FSFLGFNTAR YFELKYCGR
//
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