ID C4R8F6_KOMPG Unreviewed; 786 AA.
AC C4R8F6;
DT 07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 07-JUL-2009, sequence version 1.
DT 24-JAN-2024, entry version 75.
DE RecName: Full=Amine oxidase {ECO:0000256|RuleBase:RU000672};
DE EC=1.4.3.- {ECO:0000256|RuleBase:RU000672};
GN OrderedLocusNames=PAS_chr4_0621 {ECO:0000313|EMBL:CAY71881.1};
OS Komagataella phaffii (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Phaffomycetaceae; Komagataella.
OX NCBI_TaxID=644223 {ECO:0000313|EMBL:CAY71881.1, ECO:0000313|Proteomes:UP000000314};
RN [1] {ECO:0000313|EMBL:CAY71881.1, ECO:0000313|Proteomes:UP000000314}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GS115 / ATCC 20864 {ECO:0000313|Proteomes:UP000000314};
RX PubMed=19465926; DOI=10.1038/nbt.1544;
RA De Schutter K., Lin Y.C., Tiels P., Van Hecke A., Glinka S.,
RA Weber-Lehmann J., Rouze P., Van de Peer Y., Callewaert N.;
RT "Genome sequence of the recombinant protein production host Pichia
RT pastoris.";
RL Nat. Biotechnol. 27:561-566(2009).
CC -!- COFACTOR:
CC Name=Cu cation; Xref=ChEBI:CHEBI:23378;
CC Evidence={ECO:0000256|RuleBase:RU000672};
CC Note=Contains 1 topaquinone per subunit.
CC {ECO:0000256|RuleBase:RU000672};
CC -!- PTM: Topaquinone (TPQ) is generated by copper-dependent autoxidation of
CC a specific tyrosyl residue. {ECO:0000256|PIRSR:PIRSR600269-51,
CC ECO:0000256|RuleBase:RU000672}.
CC -!- SIMILARITY: Belongs to the copper/topaquinone oxidase family.
CC {ECO:0000256|ARBA:ARBA00007983, ECO:0000256|RuleBase:RU000672}.
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DR EMBL; FN392322; CAY71881.1; -; Genomic_DNA.
DR RefSeq; XP_002494060.1; XM_002494015.1.
DR AlphaFoldDB; C4R8F6; -.
DR SMR; C4R8F6; -.
DR STRING; 644223.C4R8F6; -.
DR EnsemblFungi; CAY71881; CAY71881; PAS_chr4_0621.
DR GeneID; 8201330; -.
DR KEGG; ppa:PAS_chr4_0621; -.
DR eggNOG; KOG1186; Eukaryota.
DR HOGENOM; CLU_015739_0_0_1; -.
DR InParanoid; C4R8F6; -.
DR OMA; CMFEIDK; -.
DR OrthoDB; 5490352at2759; -.
DR Proteomes; UP000000314; Chromosome 4.
DR GO; GO:0005507; F:copper ion binding; IEA:InterPro.
DR GO; GO:0008131; F:primary amine oxidase activity; IEA:InterPro.
DR GO; GO:0048038; F:quinone binding; IEA:InterPro.
DR GO; GO:0009308; P:amine metabolic process; IEA:UniProtKB-UniRule.
DR Gene3D; 3.10.450.40; -; 2.
DR Gene3D; 2.70.98.20; Copper amine oxidase, catalytic domain; 1.
DR InterPro; IPR000269; Cu_amine_oxidase.
DR InterPro; IPR015798; Cu_amine_oxidase_C.
DR InterPro; IPR036460; Cu_amine_oxidase_C_sf.
DR InterPro; IPR016182; Cu_amine_oxidase_N-reg.
DR InterPro; IPR015800; Cu_amine_oxidase_N2.
DR InterPro; IPR015328; DUF1965.
DR PANTHER; PTHR10638:SF20; AMINE OXIDASE; 1.
DR PANTHER; PTHR10638; COPPER AMINE OXIDASE; 1.
DR Pfam; PF01179; Cu_amine_oxid; 1.
DR Pfam; PF02727; Cu_amine_oxidN2; 1.
DR Pfam; PF09248; DUF1965; 1.
DR PRINTS; PR00766; CUDAOXIDASE.
DR SUPFAM; SSF49998; Amine oxidase catalytic domain; 1.
DR SUPFAM; SSF54416; Amine oxidase N-terminal region; 2.
PE 3: Inferred from homology;
KW Copper {ECO:0000256|ARBA:ARBA00023008, ECO:0000256|RuleBase:RU000672};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU000672};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU000672};
KW Reference proteome {ECO:0000313|Proteomes:UP000000314};
KW Signal {ECO:0000256|SAM:SignalP};
KW TPQ {ECO:0000256|ARBA:ARBA00022772, ECO:0000256|PIRSR:PIRSR600269-50}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..786
FT /note="Amine oxidase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5009950949"
FT DOMAIN 92..146
FT /note="Copper amine oxidase N2-terminal"
FT /evidence="ECO:0000259|Pfam:PF02727"
FT DOMAIN 241..294
FT /note="DUF1965"
FT /evidence="ECO:0000259|Pfam:PF09248"
FT DOMAIN 323..725
FT /note="Copper amine oxidase catalytic"
FT /evidence="ECO:0000259|Pfam:PF01179"
FT ACT_SITE 397
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR600269-50"
FT ACT_SITE 477
FT /note="Schiff-base intermediate with substrate; via
FT topaquinone"
FT /evidence="ECO:0000256|PIRSR:PIRSR600269-50"
FT MOD_RES 477
FT /note="2',4',5'-topaquinone"
FT /evidence="ECO:0000256|PIRSR:PIRSR600269-51"
SQ SEQUENCE 786 AA; 89651 MW; 7960AA05E7F98FA7 CRC64;
MRLTNLLSLT SLVALAVAVP DFYQKREAVS SKEAALLRRE ATECVSNENV LVEAPKSNIW
TSLSKDEVQE VLDLLHSTYN ITEVTKSDFF SNYVLWIETL KPNKTEALTY LDEDGDLPPR
NARTVVYFGE GEEGYFEELK VGPLPVSDET TIEPLSYYNT NGKSKLPFDV GHLDRIKSAA
KSAFLNENLN TTTMRTVLED LIGVPYEDMG CHSAAPQLHD PATGAVVDYG TCNINTENDA
ENLVPTGFFF KFDMTGRDVS QWKMLEYIYN NKVYNSAEEL YEATKKDDFV RLPKIDIDNL
DWTVIPRNDS APIRHLDDRK SPRLIEPEGR RWAYDADEEY FSWMDWGFYT SWSRDTGISF
FDITFKGERI VYELSLQELI AEYGSDDPFN QHTFYSDISY GVGNRFSLVP GFDCPSTAGY
FTTDTFEYDE FYNRTLSYCV FENQEDYSLL RHTGASYSAV TQNPTLNIRF ISTIGNYDYN
FLYKFFLDGT LEVSVRAAGY IQAGYWNPET SAPYGLKIHD VLSGSFHDHV LNYKVDLDVG
GTKNRATQYV MKDVDVEYPW APGKVYNTKQ IAREVFENED FNGINWPENG QGILLIESAE
ETNSFGNPRA YNIMPGAGGV HRIVKNSRSG PETQNWARSN LFLTKHKDTE LRSSTALNTN
ALYDPPVNFN AFLDNESLDG EDIVAWVNLG LHHLPNSNDL PNTIFSTAHA SFMLTPFNYF
DSENSRDTTQ QVYYTYDDET EESSWEFYGN DWSSCGVEVA EPNFEEYVYG RGTRINKKMT
NSDEVY
//