ID C4RJE3_MICS3 Unreviewed; 554 AA.
AC C4RJE3;
DT 07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 07-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=DNA-directed DNA polymerase {ECO:0000313|EMBL:EEP70668.1};
GN ORFNames=MCAG_00995 {ECO:0000313|EMBL:EEP70668.1};
OS Micromonospora sp. (strain ATCC 39149 / NRRL 15099 / SCC 1413).
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Micromonospora.
OX NCBI_TaxID=219305 {ECO:0000313|EMBL:EEP70668.1, ECO:0000313|Proteomes:UP000010307};
RN [1] {ECO:0000313|Proteomes:UP000010307}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 39149 / NRRL 15099 / SCC 1413
RC {ECO:0000313|Proteomes:UP000010307};
RG The Broad Institute Genome Sequencing Platform;
RG Broad Institute Microbial Sequencing Center;
RA Fischbach M., Godfrey P., Ward D., Young S., Kodira C.D., Zeng Q.,
RA Koehrsen M., Alvarado L., Berlin A.M., Borenstein D., Chen Z., Engels R.,
RA Freedman E., Gellesch M., Goldberg J., Griggs A., Gujja S., Heiman D.I.,
RA Hepburn T.A., Howarth C., Jen D., Larson L., Lewis B., Mehta T., Park D.,
RA Pearson M., Roberts A., Saif S., Shea T.D., Shenoy N., Sisk P., Stolte C.,
RA Sykes S.N., Walk T., White J., Yandava C., Straight P., Clardy J., Hung D.,
RA Kolter R., Mekalanos J., Walker S., Walsh C.T., Wieland-Brown L.C.,
RA Galagan J., Nusbaum C., Birren B.;
RT "The genome sequence of Micromonospora carbonacea var. africana strain ATCC
RT 39149.";
RL Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- SIMILARITY: Belongs to the DNA polymerase type-A family.
CC {ECO:0000256|ARBA:ARBA00007705}.
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DR EMBL; GG657738; EEP70668.1; -; Genomic_DNA.
DR AlphaFoldDB; C4RJE3; -.
DR STRING; 219305.MCAG_00995; -.
DR eggNOG; COG0749; Bacteria.
DR HOGENOM; CLU_035229_0_0_11; -.
DR OrthoDB; 4414061at2; -.
DR Proteomes; UP000010307; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006261; P:DNA-templated DNA replication; IEA:InterPro.
DR CDD; cd06444; DNA_pol_A; 1.
DR Gene3D; 3.30.70.370; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR InterPro; IPR001098; DNA-dir_DNA_pol_A_palm_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR002298; DNA_polymerase_A.
DR PANTHER; PTHR10133; DNA POLYMERASE I; 1.
DR PANTHER; PTHR10133:SF62; DNA POLYMERASE THETA; 1.
DR Pfam; PF00476; DNA_pol_A; 1.
DR SMART; SM00482; POLAc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
PE 3: Inferred from homology;
KW DNA-directed DNA polymerase {ECO:0000313|EMBL:EEP70668.1};
KW Nucleotidyltransferase {ECO:0000313|EMBL:EEP70668.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000010307};
KW Transferase {ECO:0000313|EMBL:EEP70668.1}.
FT DOMAIN 312..514
FT /note="DNA-directed DNA polymerase family A palm"
FT /evidence="ECO:0000259|SMART:SM00482"
FT REGION 97..128
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 436..458
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 554 AA; 57948 MW; 9C88D389A2610C46 CRC64;
MLVAVEADDR GGGVLRPLDP AGPAEQVADL AAAVAAREAA THPRWVWGSG ATVYPALLRA
GVRLDRCHDV ELTESLLLGH AGRWGEPRSP AAAWARLTGA PVPPDPSPRP AEPPGHGQGA
LFDTLPGPPG PGVEALTRVY ADQLDRIAAT AHPGRFRLLV AAESAGALIA AEMGAAGLPW
RAEVHDEILT ELLGEPSPVG GPPRRLAELA ARIAEAFGVR QVHADSPAEL LRAFARAGVE
LPNTRAWVLR GVDHPAVPLV LEHKELYRIW TAHGWAWRDA WVRGGRFHPE YVPGGVVSGR
WATRGGGALQ IPKVIRRAVV ADPGWRLVVA DAGQLEPRVL AAVSGDARLA AAGGAGDLYA
ALARDSFGGD RPRAKVALLG AMYGQTGGMA VPALTVLRRN YPTAFAYVEA AARTGEAGGL
VRSWLGRTCP PGAAGFADGD DAGIDPEAAV DPQGPRARAA RSRGRFTRNF VIQATAAEWA
STLLATLRTA LAGSDAELVF FQHDEVIVHC PAGQADEVAE AIRASGARAT ALLFGDTPVR
FPLDVSVVGC YADA
//
