ID C4RJY2_MICS3 Unreviewed; 517 AA.
AC C4RJY2;
DT 07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 07-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Rifamycin polyketide synthase {ECO:0000313|EMBL:EEP74811.1};
DE Flags: Fragment;
GN ORFNames=MCAG_05138 {ECO:0000313|EMBL:EEP74811.1};
OS Micromonospora sp. (strain ATCC 39149 / NRRL 15099 / SCC 1413).
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Micromonospora.
OX NCBI_TaxID=219305 {ECO:0000313|EMBL:EEP74811.1, ECO:0000313|Proteomes:UP000010307};
RN [1] {ECO:0000313|Proteomes:UP000010307}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 39149 / NRRL 15099 / SCC 1413
RC {ECO:0000313|Proteomes:UP000010307};
RG The Broad Institute Genome Sequencing Platform;
RG Broad Institute Microbial Sequencing Center;
RA Fischbach M., Godfrey P., Ward D., Young S., Kodira C.D., Zeng Q.,
RA Koehrsen M., Alvarado L., Berlin A.M., Borenstein D., Chen Z., Engels R.,
RA Freedman E., Gellesch M., Goldberg J., Griggs A., Gujja S., Heiman D.I.,
RA Hepburn T.A., Howarth C., Jen D., Larson L., Lewis B., Mehta T., Park D.,
RA Pearson M., Roberts A., Saif S., Shea T.D., Shenoy N., Sisk P., Stolte C.,
RA Sykes S.N., Walk T., White J., Yandava C., Straight P., Clardy J., Hung D.,
RA Kolter R., Mekalanos J., Walker S., Walsh C.T., Wieland-Brown L.C.,
RA Galagan J., Nusbaum C., Birren B.;
RT "The genome sequence of Micromonospora carbonacea var. africana strain ATCC
RT 39149.";
RL Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; GG657738; EEP74811.1; -; Genomic_DNA.
DR AlphaFoldDB; C4RJY2; -.
DR STRING; 219305.MCAG_05138; -.
DR eggNOG; COG3321; Bacteria.
DR HOGENOM; CLU_000022_16_2_11; -.
DR Proteomes; UP000010307; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF51; PHENOLPHTHIOCEROL_PHTHIOCEROL POLYKETIDE SYNTHASE SUBUNIT E; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000010307};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 43..454
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT NON_TER 517
FT /evidence="ECO:0000313|EMBL:EEP74811.1"
SQ SEQUENCE 517 AA; 53563 MW; 3BA9FFB2875789CA CRC64;
MRLAATLVFD HPTALAVAQH LRSQVTGGSP GLAAEPSSVA GSDEPIAIVG MACRLPGGVG
SPEDLWDLVA AGRDGIGDFP EDRGWDIERW YDPEPGRPGK TYVRAGGFLA GAGAFDASFF
GISPREAVLM DPQQRLLLEV SWEAFERAGI VPATLRGSRT GVFAGVMYHD YPGSASVGSV
VSGRIAYTLG LEGPAVSVDT ACSSSLVALH WAAHALRQGE CDLALAGGVT VMATPETFVE
FSGQGGLSRD GRCRSYADGA DGTGWAEGVG VLLLEKLSDA QRNGHEVLAV VRGSAVNQDG
ASNGITAPSG LAQQRVIRAA LANAGLDVRG VDAVEGHGTA TRLGDPIEVQ ALLATYGQGR
ERPLWLGSLK SNLGHTQAAA GVAGVIKMVM ALRHSELPRT LHVGTPSSVV DWSAGAVELL
ADSRSWPSVV GRVRRAGVSS FGISGTNAHV IVEEAPAQVP EAVPAGRPAV AGTLPWVVSG
RSAGALRAQA ERLLDFLDEE PERDLRDVGF SLATGRS
//
