ID C4RK37_MICS3 Unreviewed; 672 AA.
AC C4RK37;
DT 07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 07-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Polyketide synthase {ECO:0000313|EMBL:EEP74866.1};
DE Flags: Fragment;
GN ORFNames=MCAG_05193 {ECO:0000313|EMBL:EEP74866.1};
OS Micromonospora sp. (strain ATCC 39149 / NRRL 15099 / SCC 1413).
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Micromonospora.
OX NCBI_TaxID=219305 {ECO:0000313|EMBL:EEP74866.1, ECO:0000313|Proteomes:UP000010307};
RN [1] {ECO:0000313|Proteomes:UP000010307}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 39149 / NRRL 15099 / SCC 1413
RC {ECO:0000313|Proteomes:UP000010307};
RG The Broad Institute Genome Sequencing Platform;
RG Broad Institute Microbial Sequencing Center;
RA Fischbach M., Godfrey P., Ward D., Young S., Kodira C.D., Zeng Q.,
RA Koehrsen M., Alvarado L., Berlin A.M., Borenstein D., Chen Z., Engels R.,
RA Freedman E., Gellesch M., Goldberg J., Griggs A., Gujja S., Heiman D.I.,
RA Hepburn T.A., Howarth C., Jen D., Larson L., Lewis B., Mehta T., Park D.,
RA Pearson M., Roberts A., Saif S., Shea T.D., Shenoy N., Sisk P., Stolte C.,
RA Sykes S.N., Walk T., White J., Yandava C., Straight P., Clardy J., Hung D.,
RA Kolter R., Mekalanos J., Walker S., Walsh C.T., Wieland-Brown L.C.,
RA Galagan J., Nusbaum C., Birren B.;
RT "The genome sequence of Micromonospora carbonacea var. africana strain ATCC
RT 39149.";
RL Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; GG657738; EEP74866.1; -; Genomic_DNA.
DR AlphaFoldDB; C4RK37; -.
DR STRING; 219305.MCAG_05193; -.
DR eggNOG; COG0236; Bacteria.
DR eggNOG; COG3321; Bacteria.
DR HOGENOM; CLU_409139_0_0_11; -.
DR Proteomes; UP000010307; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF37; FATTY ACID SYNTHASE; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF21089; PKS_DH_N; 1.
DR Pfam; PF00550; PP-binding; 1.
DR Pfam; PF14765; PS-DH; 1.
DR SMART; SM00826; PKS_DH; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000010307};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 346..423
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 488..672
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT NON_TER 672
FT /evidence="ECO:0000313|EMBL:EEP74866.1"
SQ SEQUENCE 672 AA; 70210 MW; F0C465714F14C170 CRC64;
MGTDHDHGTA DRAGGVTASR SDVRELLEAF GRGELTRAEV TQRIAALSGP AVPEPVSRIW
RHDEPFLAAH VIFGQQVLLG MAHCAMAAEA ARSTGGASAD LANVAFHEPV VLTAGQSATV
TVRARRDHDR VRFDSVYTVD GGPERRSVSG EFTTPTAPGE PVDLAALLAA ATAERAASEV
AAVPLLARDP ALRSVERVWL TTGGALGRLR LDPAARAAVT DLAVHPALLD GGFVVGAAAL
EPALLTPTDG STWVTVAIRA VRGGGTALPD DCWCRAEITG QQSDLISMDL TYCDDTGTVL
LAVSGLSVRR VGSGVVTQPD PGAATAAPAP GVAPTVGAAA AVPAAGGLAE RVAGYLAALL
TQAAGAGANP DRRVPFMQLG ADSSTLIGLT REIENDLGIE LYPTLFFEHQ TIDELTAALV
AAHGDVLAHR LPAAAPMSAR AEGSVPVEPV PAPAVAPIQS PAGPASAPAV VAASASAVVA
LDPSRDPRRD IAVIGMDARF AGSPDVRAFW AHVRAGTDLV TEIPADRWNW RDWYDADPAE
PNRTYSRWGS FIEADKFDPA FFGVSRREAI WLDPQLRVLL EVVHGTTEDA GYADRLRGSR
TGLYLGVSFH EYWDEIIRAG VPITDYQAVT GVPSSLSGRL SYLFDLHGPS VPVDNACASS
LTALHLAVRA LR
//
