ID C4XFR3_MYCFP Unreviewed; 560 AA.
AC C4XFR3;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN OrderedLocusNames=MBIO_0720 {ECO:0000313|EMBL:BAH69985.1};
OS Mycoplasmopsis fermentans (strain ATCC 19989 / NBRC 14854 / NCTC 10117 /
OS PG18) (Mycoplasma fermentans).
OC Bacteria; Mycoplasmatota; Mycoplasmoidales; Metamycoplasmataceae;
OC Mycoplasmopsis.
OX NCBI_TaxID=496833 {ECO:0000313|EMBL:BAH69985.1, ECO:0000313|Proteomes:UP000006810};
RN [1] {ECO:0000313|EMBL:BAH69985.1, ECO:0000313|Proteomes:UP000006810}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 19989 / NBRC 14854 / NCTC 10117 / PG18
RC {ECO:0000313|Proteomes:UP000006810};
RX PubMed=19219498; DOI=10.1007/s00284-009-9362-6;
RA Ishida N., Irikura D., Matsuda K., Sato S., Asano K.;
RT "Molecular cloning and expression of a novel cholinephosphotransferase
RT involved in glycoglycerophospholipid biosynthesis of Mycoplasma
RT fermentans.";
RL Curr. Microbiol. 58:535-540(2009).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
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DR EMBL; AP009608; BAH69985.1; -; Genomic_DNA.
DR AlphaFoldDB; C4XFR3; -.
DR REBASE; 21887; M.Mfe18ORF720P.
DR KEGG; mfp:MBIO_0720; -.
DR PATRIC; fig|496833.3.peg.314; -.
DR eggNOG; COG0286; Bacteria.
DR HOGENOM; CLU_037306_0_0_14; -.
DR Proteomes; UP000006810; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0006306; P:DNA methylation; IEA:InterPro.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR42933:SF1; SITE-SPECIFIC DNA-METHYLTRANSFERASE (ADENINE-SPECIFIC); 1.
DR PANTHER; PTHR42933; SLR6095 PROTEIN; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000006810};
KW Restriction system {ECO:0000256|ARBA:ARBA00022747};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 185..514
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
FT COILED 529..556
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 560 AA; 64433 MW; 07C5F46B95A36E7B CRC64;
MQGNTLRRKM TNFTKLENNI KSIIDDLKGL CSTNGLSNTA GEEIVVTSVF LYKFLNDKFI
SNLKKFAKEL NVPFEEIIKN SNYMDGFYDA YPQDVAFKYE DTIDYLVGYI NEDDFYQKFD
DTLIRISDYK QNEAFNVDTA EGTKKPLFVR LSTFVEPSKR NNFTKNVFSY ITRDRFDFGE
AFNNNYDFFS TIFEYLISDY NIASGKYAEY FTPQTLSKAI GEILVKMSPI EDKIYEIYDP
SAGSGSLVLH LANELGEGKF GNKARVYTQD ISQKSSRFLR INMLLNGLKE SLDNIIEGDT
LLTPTHYKKA GDATTGLKQF DFITSNPPFK TDFSSTRDNI ELMWQNTERF FAGIPKVPKT
KKDSMAIYLL FIQHILYSLK EGGKAAIVVP TGFITAQSGI EKTIRQYIID RKWLKGVISM
PSNIFANTGT NVSVLFIDKT NTNGEVLLMD ASKMGHKEKV KDLQKTVLTH DELNKIVNDF
VNHKVEDDFT ISVTYDQIKE RNYSLSAGQY FEVKIEYVDI TQEEFDKMID DFNKELEQFT
KDTEEFQKEM SKTLKELKLK
//
