ID C4XVD3_TETNG Unreviewed; 501 AA.
AC C4XVD3;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=IKAROS family zinc finger 4 {ECO:0000313|Ensembl:ENSTNIP00000018118.1};
DE SubName: Full=Putative Eos2 protein {ECO:0000313|EMBL:CAU95877.1};
DE Flags: Fragment;
GN Name=eos2 {ECO:0000313|EMBL:CAU95877.1};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|EMBL:CAU95877.1};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|EMBL:CAU95877.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=19342657;
RA John L.B., Yoong S., Ward A.C.;
RT "Evolution of the Ikaros gene family: implications for the origins of
RT adaptive immunity.";
RL J. Immunol. 182:4792-4799(2009).
RN [3] {ECO:0000313|Ensembl:ENSTNIP00000018118.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; BN001291; CAU95877.1; -; mRNA.
DR STRING; 99883.ENSTNIP00000018118; -.
DR Ensembl; ENSTNIT00000018342.1; ENSTNIP00000018118.1; ENSTNIG00000015065.1.
DR GeneTree; ENSGT00940000158308; -.
DR HOGENOM; CLU_025502_1_0_1; -.
DR OMA; RMNADEC; -.
DR TreeFam; TF331189; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 5.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR24404; ZINC FINGER PROTEIN; 1.
DR PANTHER; PTHR24404:SF28; ZINC FINGER PROTEIN EOS; 1.
DR Pfam; PF00096; zf-C2H2; 2.
DR SMART; SM00355; ZnF_C2H2; 6.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 3.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 5.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
PE 2: Evidence at transcript level;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 85..112
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 113..140
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 141..164
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 174..202
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 25..78
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 240..410
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..17
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 25..57
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 247..262
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 352..401
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:CAU95877.1"
SQ SEQUENCE 501 AA; 54806 MW; 8822ACF175CEA8EC CRC64;
PFAMSPNSQQ SSPRRPLSAH SIKVELYSDD ESPGSRDSLR DDGRKEVGGE RVDAGRGRLK
AAVGSEVSSP KTASPGPIRL SNGKLQCELC GMVCTGPNVL MVHKRSHTGE RPFKCNQCGA
SFTQKGNLLR HIKLHSGEKP FKCNICNYAC RRRDALAGHL RTHTVAPQTV GKPFKCAYCS
RSYKQQNTLE DHLERCHSYL KSLGRQAAVV TQTAPGTEIM DGMRKSNEKS LLVDRLAMSI
TKRKRSTPQK SLGEKHMHLE LPEAPCDLSS SSEKDEELTS SRPAAAIPAA SLHVDGSKKE
NQQPSPLSPL HPSFPAAQRF GQQQRVRPGA PGPRRDGAGT RRPALRPQPA SPNGCPDSTD
TESTAEEQSS RAPGPIGTSN SNHLLYRTPG LPHSRSTASP GQAKDPDWER AGLVPPTLIK
KTPGSLLSPT ESVQVLDSHG HPVRSFRCLH CHILFLDYVM FTIHMGCHGF RRPFECNICG
HSSRDRYEFS SHISRGEHQV G
//
