ID C4XWL2_CLAL4 Unreviewed; 964 AA.
AC C4XWL2;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE RecName: Full=DNA repair protein RAD5 {ECO:0000256|ARBA:ARBA00013412};
DE Flags: Fragment;
GN ORFNames=CLUG_00335 {ECO:0000313|EMBL:EEQ36212.1};
OS Clavispora lusitaniae (strain ATCC 42720) (Yeast) (Candida lusitaniae).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Metschnikowiaceae; Clavispora.
OX NCBI_TaxID=306902 {ECO:0000313|EMBL:EEQ36212.1, ECO:0000313|Proteomes:UP000007703};
RN [1] {ECO:0000313|EMBL:EEQ36212.1, ECO:0000313|Proteomes:UP000007703}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 42720 {ECO:0000313|EMBL:EEQ36212.1,
RC ECO:0000313|Proteomes:UP000007703};
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W., Harris D., Hoyer L.L., Hube B., Klis F.M.,
RA Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M., Nikolaou E.,
RA Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F., Sherlock G.,
RA Shah P., Silverstein K.A., Skrzypek M.S., Soll D., Staggs R.,
RA Stansfield I., Stumpf M.P., Sudbery P.E., Srikantha T., Zeng Q., Berman J.,
RA Berriman M., Heitman J., Gow N.A., Lorenz M.C., Birren B.W., Kellis M.,
RA Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the SNF2/RAD54 helicase family.
CC {ECO:0000256|ARBA:ARBA00007025}.
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DR EMBL; CH408076; EEQ36212.1; -; Genomic_DNA.
DR RefSeq; XP_002619176.1; XM_002619130.1.
DR AlphaFoldDB; C4XWL2; -.
DR STRING; 306902.C4XWL2; -.
DR GeneID; 8500065; -.
DR KEGG; clu:CLUG_00335; -.
DR VEuPathDB; FungiDB:CLUG_00335; -.
DR HOGENOM; CLU_000315_2_5_1; -.
DR InParanoid; C4XWL2; -.
DR OMA; CILFSQW; -.
DR OrthoDB; 200191at2759; -.
DR Proteomes; UP000007703; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0140658; F:ATP-dependent chromatin remodeler activity; IEA:InterPro.
DR GO; GO:0016818; F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd18008; DEXDc_SHPRH-like; 1.
DR Gene3D; 3.40.50.10810; Tandem AAA-ATPase domain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR014905; HIRAN.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038718; SNF2-like_sf.
DR InterPro; IPR000330; SNF2_N.
DR InterPro; IPR018957; Znf_C3HC4_RING-type.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR45626:SF22; DNA REPAIR PROTEIN RAD5; 1.
DR PANTHER; PTHR45626; TRANSCRIPTION TERMINATION FACTOR 2-RELATED; 1.
DR Pfam; PF08797; HIRAN; 1.
DR Pfam; PF00176; SNF2-rel_dom; 1.
DR Pfam; PF00097; zf-C3HC4; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00910; HIRAN; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000007703};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 532..724
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 892..939
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 29..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 84..104
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 381..404
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 167..194
FT /evidence="ECO:0000256|SAM:Coils"
FT NON_TER 964
FT /evidence="ECO:0000313|EMBL:EEQ36212.1"
SQ SEQUENCE 964 AA; 110495 MW; 845EB70EF26154AC CRC64;
MHIYLEQRDV LTPPSKLFAS LKFMEGKKRF FPSPSRSPNP AETVPSKEAL FVEDEDEILE
VEPHQASQAT RNGSAQQLSV DVPQTVPRRE PLPNNLEAPT PAEPSLSDIG FELFQSQLSS
VIGDASMKAM RHLYAKYFNR PNYIQLASNE YFNGISFDDE SSGEASENVQ EDKREELKQV
MERMNTEARN EAEMKKAMGW KRYIGTLDVQ AWATRPYLRS LRYQQELQLK RLIPNKMKKS
SIVASKFGDS AVIRLYTSEA DGSREIGRLP EDITRILSPL IDLEIANFSA SVIMETKGRL
SIGDPFFLQI KCYLNNNTFV DHGQVVGEEE NSQSKRRKTA KLGITFSQET EAEAALRLKQ
KSISRLFDKL SIIPYDKSSV NTDAEEIPDD DSSVSSTPKP EIAPTEELSL EQLKQFYTAN
QQSDFLENLP ETTTPPEENF ALTLRPYQKH GLSWMLSREK ELDLLEELSV NNSEVLSTQK
RQAIRNQDDE VMDPLWSTFK WPQDPANPDL STSESEFFYA NLYNGELSTE KPVLKSFLKG
GILADEMGLG KTISTLSLIH SVPYDSATAR TGTRNYASKT TLIIVPMSLL SQWKKEFDRS
NKNSNHRCHI YYGDSVQTDL SLLLCNRSEN IPIVLLTTYG TVQSEWTRIN KLRDANGKLP
KIGLFSVEFF RIVVDEGHNI RNRTTKTAKS VHELESRRKW ILTGTPVVNR LDDIFSLVKF
LRLEPWSNFS YWKTFVTLPF EQKKFQQTLD VVKSILQPIF LRRTKNMKQK DGTPLIDLPS
KEVVVEELEF SDREQLFYDF FKSRAYNSFK EGLKSGELLK KYTQILTHIL RLRQVCCHPD
LVAASSELDD SWKEELAAFE EPIKKEKFWS ETMMKEKLYS LYAKVHIEDS ECSICTQAPI
SIGELTLTEC GHQYCFHCIL EHIEFQTNNG SEPLCPDCRH PISKYRLFKV LSKSTSKKKI
RSTR
//
