ID   C4XYF4_CLAL4            Unreviewed;      1145 AA.
AC   C4XYF4;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   08-NOV-2023, entry version 63.
DE   RecName: Full=Ras-GAP domain-containing protein {ECO:0000259|PROSITE:PS50018};
GN   ORFNames=CLUG_00977 {ECO:0000313|EMBL:EEQ36854.1};
OS   Clavispora lusitaniae (strain ATCC 42720) (Yeast) (Candida lusitaniae).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Metschnikowiaceae; Clavispora.
OX   NCBI_TaxID=306902 {ECO:0000313|EMBL:EEQ36854.1, ECO:0000313|Proteomes:UP000007703};
RN   [1] {ECO:0000313|EMBL:EEQ36854.1, ECO:0000313|Proteomes:UP000007703}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 42720 {ECO:0000313|EMBL:EEQ36854.1,
RC   ECO:0000313|Proteomes:UP000007703};
RX   PubMed=19465905; DOI=10.1038/nature08064;
RA   Butler G., Rasmussen M.D., Lin M.F., Santos M.A., Sakthikumar S.,
RA   Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA   Arnaud M.B., Bates S., Brown A.J., Brunke S., Costanzo M.C.,
RA   Fitzpatrick D.A., de Groot P.W., Harris D., Hoyer L.L., Hube B., Klis F.M.,
RA   Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M., Nikolaou E.,
RA   Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F., Sherlock G.,
RA   Shah P., Silverstein K.A., Skrzypek M.S., Soll D., Staggs R.,
RA   Stansfield I., Stumpf M.P., Sudbery P.E., Srikantha T., Zeng Q., Berman J.,
RA   Berriman M., Heitman J., Gow N.A., Lorenz M.C., Birren B.W., Kellis M.,
RA   Cuomo C.A.;
RT   "Evolution of pathogenicity and sexual reproduction in eight Candida
RT   genomes.";
RL   Nature 459:657-662(2009).
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DR   EMBL; CH408076; EEQ36854.1; -; Genomic_DNA.
DR   RefSeq; XP_002619818.1; XM_002619772.1.
DR   AlphaFoldDB; C4XYF4; -.
DR   STRING; 306902.C4XYF4; -.
DR   GeneID; 8499965; -.
DR   KEGG; clu:CLUG_00977; -.
DR   VEuPathDB; FungiDB:CLUG_00977; -.
DR   HOGENOM; CLU_000972_0_0_1; -.
DR   InParanoid; C4XYF4; -.
DR   OMA; CANKYYD; -.
DR   OrthoDB; 12619at2759; -.
DR   Proteomes; UP000007703; Unassembled WGS sequence.
DR   GO; GO:0015629; C:actin cytoskeleton; IEA:UniProt.
DR   GO; GO:0006996; P:organelle organization; IEA:UniProt.
DR   CDD; cd12206; RasGAP_IQGAP_related; 1.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR000593; RasGAP_C.
DR   InterPro; IPR001936; RasGAP_dom.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   PANTHER; PTHR14149:SF14; PATTERNED EXPRESSION SITE; 1.
DR   PANTHER; PTHR14149; RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF; 1.
DR   Pfam; PF00612; IQ; 1.
DR   Pfam; PF00616; RasGAP; 1.
DR   Pfam; PF03836; RasGAP_C; 1.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   SUPFAM; SSF143885; RGC domain-like; 1.
DR   PROSITE; PS50096; IQ; 1.
DR   PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007703}.
FT   DOMAIN          499..717
FT                   /note="Ras-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50018"
FT   COILED          366..400
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          961..988
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   1145 AA;  133142 MW;  4655D0A90D8B569C CRC64;
     MFVDKIMLKS YDSELTQLYA IIRANLTRKR TVHRHRDELL CYSDNVRNLQ ALARGKIIRK
     FLNYEFDESA TASISKLQSL IRATKIRESY YLKKSALSRY EAQISAFQSR IRAKDTYFRA
     STLATNRDRI EDSIVVIQSN IRRFLYQKHT NKTIVSKLSG SEGITQLQSI IRGGKVRNEV
     RYYLRNISKL RYEIREIQSI ARGGILRTRL CNNVLITLMG EDIKMNELFA KVRGNNVRRV
     MNYKKSVLEC VSKSEIIPIQ SMFRGILFRF YRDEDLECIY EQIDSITTLQ SKIRANFVTS
     ELKTMMDYYN RNVNLVIKAQ SYLKSKYTQN AYKSLINMKS PPLSVVRKFA HLLSDSGSDF
     QEEMELANLK DKIFEKSKNN EELESQIENL DIKLSLLDKN KITIEEFMKH NHKFKTYKPI
     MSKNVGTNGL DKLSSSAKKR IELYSSMLYF LQTKASYWIR LYEEHPSRNK DKFTTKLQDN
     ILSVFPLAQG TINSHSRVEY FFLKFVSSLM ELDIKYCQNV ADITKMKNAF WIDFLVDFHS
     HSYQRMHLKS LIGKVVEAII DDDELSFESD PAKIYSQLRE QDIRAYGSSV MDEGVTAQEA
     IKDPRVSSAF VSNLMALRDA TTDTVEMLRL TIDKLPVHIR FLAKKAYMVS QLHFPDQSDK
     HHLAVAGAVF IKHYIGSIFH LPENYGFSTK RAFGSRPEYM AVNNLRYLNR VLLQVFSMKP
     FSDNFMKPLN DYVTSCTENT RSLIREIINV KDLEAEYEMN EYDDIVAHER PQLTMRVADM
     ISIEKLVRPN IDIMAPSADD QLRSVAEKLR ELNDAADDYV SLTEMGSYTL TLSPVTKEDS
     VADSKAKTLF TQAKRCLLYM IRVEEGDDLL ELFIHGIKPV HEVTFKEIIA SEADSSKPSE
     ANPYRASYLG DMPNMTYVEL KKLALKVILQ LERMGQVSRK DSFQELLNQI VVDIKTKDKQ
     RINRKEQMEI ARQTVRKLEE KERFLKRQLG DYNTHIDEVL DQLQLRPKEK KIFNIIPVFS
     KQYFYHRQLK KNNRLPKFGS YRYSAKKLLE QNVIRDLGGA LQERFATSSK LHFMFSCHKS
     GAFVIEAADG LATIPGACTT ITLDQLLDHQ YEKKKYWEMF NGMAAFETEN LASLIFRKFY
     DIKKD
//