ID C4XYL9_CLAL4 Unreviewed; 350 AA.
AC C4XYL9;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE RecName: Full=3-beta hydroxysteroid dehydrogenase/isomerase domain-containing protein {ECO:0000259|Pfam:PF01073};
GN ORFNames=CLUG_01042 {ECO:0000313|EMBL:EEQ36919.1};
OS Clavispora lusitaniae (strain ATCC 42720) (Yeast) (Candida lusitaniae).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Metschnikowiaceae; Clavispora.
OX NCBI_TaxID=306902 {ECO:0000313|EMBL:EEQ36919.1, ECO:0000313|Proteomes:UP000007703};
RN [1] {ECO:0000313|EMBL:EEQ36919.1, ECO:0000313|Proteomes:UP000007703}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 42720 {ECO:0000313|EMBL:EEQ36919.1,
RC ECO:0000313|Proteomes:UP000007703};
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W., Harris D., Hoyer L.L., Hube B., Klis F.M.,
RA Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M., Nikolaou E.,
RA Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F., Sherlock G.,
RA Shah P., Silverstein K.A., Skrzypek M.S., Soll D., Staggs R.,
RA Stansfield I., Stumpf M.P., Sudbery P.E., Srikantha T., Zeng Q., Berman J.,
RA Berriman M., Heitman J., Gow N.A., Lorenz M.C., Birren B.W., Kellis M.,
RA Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004406}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004406}.
CC -!- SIMILARITY: Belongs to the 3-beta-HSD family.
CC {ECO:0000256|ARBA:ARBA00009219}.
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DR EMBL; CH408076; EEQ36919.1; -; Genomic_DNA.
DR RefSeq; XP_002619883.1; XM_002619837.1.
DR AlphaFoldDB; C4XYL9; -.
DR STRING; 306902.C4XYL9; -.
DR GeneID; 8499586; -.
DR KEGG; clu:CLUG_01042; -.
DR VEuPathDB; FungiDB:CLUG_01042; -.
DR HOGENOM; CLU_007383_6_8_1; -.
DR InParanoid; C4XYL9; -.
DR OMA; STAHWFD; -.
DR OrthoDB; 1133at2759; -.
DR Proteomes; UP000007703; Unassembled WGS sequence.
DR GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43245; BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA; 1.
DR PANTHER; PTHR43245:SF51; SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2; 1.
DR Pfam; PF01073; 3Beta_HSD; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000007703}.
FT DOMAIN 9..278
FT /note="3-beta hydroxysteroid dehydrogenase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF01073"
SQ SEQUENCE 350 AA; 39121 MW; 0D7DA9DB2F9CCA3E CRC64;
MTELTSVLLV GGSGFLGLHL VQQFRNKCPN VKIHVFDIRP IPEKLSKYFT FDPSEIVFHK
GDLTSEKDVR KAVEASKCEV IVHSASPIHG MAQDIYYKVN VVGTKNLVYV AKSSPVKALV
YTSSAGVIFN GKDVFNANED WPYPRVHMDG YNETKAIAEQ YVMESNDPDN LLTVCLRPAG
IFGPGDRQLV PGLRTAARLG QSKFQLGDNN NLFDWTYAGN VADAHVLAAQ KILEEKNEEI
LGGETFFITN DAPTYFWTLA RTVWKADGHI DKYNIVLSRP VAIAAGYLSQ FFSKLLNKEP
GLTAFRAKIT CATRYHDITK AKELLGYVPE VSLEEGIKHT LDWIYETHKD
//
