ID C4Y072_CLAL4 Unreviewed; 1518 AA.
AC C4Y072;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 24-JAN-2024, entry version 60.
DE RecName: Full=Vacuolar membrane-associated protein IML1 {ECO:0000256|ARBA:ARBA00018529};
DE AltName: Full=Vacuolar membrane-associated protein iml1 {ECO:0000256|ARBA:ARBA00021881};
GN ORFNames=CLUG_01604 {ECO:0000313|EMBL:EEQ37481.1};
OS Clavispora lusitaniae (strain ATCC 42720) (Yeast) (Candida lusitaniae).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Metschnikowiaceae; Clavispora.
OX NCBI_TaxID=306902 {ECO:0000313|EMBL:EEQ37481.1, ECO:0000313|Proteomes:UP000007703};
RN [1] {ECO:0000313|EMBL:EEQ37481.1, ECO:0000313|Proteomes:UP000007703}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 42720 {ECO:0000313|EMBL:EEQ37481.1,
RC ECO:0000313|Proteomes:UP000007703};
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W., Harris D., Hoyer L.L., Hube B., Klis F.M.,
RA Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M., Nikolaou E.,
RA Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F., Sherlock G.,
RA Shah P., Silverstein K.A., Skrzypek M.S., Soll D., Staggs R.,
RA Stansfield I., Stumpf M.P., Sudbery P.E., Srikantha T., Zeng Q., Berman J.,
RA Berriman M., Heitman J., Gow N.A., Lorenz M.C., Birren B.W., Kellis M.,
RA Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
CC -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000256|ARBA:ARBA00004148};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004148}.
CC -!- SIMILARITY: Belongs to the IML1 family.
CC {ECO:0000256|ARBA:ARBA00005643}.
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DR EMBL; CH408077; EEQ37481.1; -; Genomic_DNA.
DR RefSeq; XP_002618145.1; XM_002618099.1.
DR STRING; 306902.C4Y072; -.
DR GeneID; 8499057; -.
DR KEGG; clu:CLUG_01604; -.
DR VEuPathDB; FungiDB:CLUG_01604; -.
DR HOGENOM; CLU_000935_1_1_1; -.
DR InParanoid; C4Y072; -.
DR OMA; REMWHFE; -.
DR OrthoDB; 946033at2759; -.
DR Proteomes; UP000007703; Unassembled WGS sequence.
DR GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd04449; DEP_DEPDC5-like; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR027244; IML1.
DR InterPro; IPR048255; IML1_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR13179; DEP DOMAIN CONTAINING PROTEIN 5; 1.
DR PANTHER; PTHR13179:SF8; GATOR COMPLEX PROTEIN DEPDC5; 1.
DR Pfam; PF00610; DEP; 1.
DR Pfam; PF12257; IML1; 1.
DR SMART; SM00049; DEP; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50186; DEP; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000007703}.
FT DOMAIN 1107..1182
FT /note="DEP"
FT /evidence="ECO:0000259|PROSITE:PS50186"
FT REGION 101..120
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 637..661
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 705..746
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1199..1242
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 705..722
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 723..746
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1208..1242
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1518 AA; 173752 MW; 41B340A3ACC61B9C CRC64;
MQNVRLGNNA KQKESIDGDL SSFLRQNPTS PISMNHRAPN RSRFVAGNMS TNTTGSTLIV
GKNSVTSSVG GVGAKNFSSN PLHRHRIHHN RANLETKFAR VKSPTHTTNV PSSSDSDAES
PIQMPVWFHE LRSYSEDVII DRNAIPNLRV GNLYELEPME KTANAKRPNK YVFLVRESNI
LGKDVTESPN TSSVSTAKAK TNFQISLLST FQKLLDIPPR STVQLKCISN IEDVMLDTVE
IYLKDVNFPR DSQWGLASSM VGSCCYVNQR VSFSGNRIGY INTLYKDGRS LFSGYIGIKT
NIVFRSESAK LVFLVQMSRE MWHFEENGEI MFHKLVNALF PKIFKKWRAN NSHHSITIVL
FTSVDLTYTP WISLGGGERP SNCQDYYRVV VDQVSVFVWD KIMAALRLEF ANFKRDILLH
LEDNKYQIKG EPCPAVKGNL LEAINLSLSL VSDRFRNTDL RHSVNHLVVI TPGTGIFDVD
FDQLSDTSRK MLSLDIALDI VSLSQQPLHT VPLFRYRDAE GKVNHCVPKW CDVSYYAGEV
GSSFHWIPRC KIYELQMMGV MENEINEIQI ERLNFKDNSR VIESMDKYDE ALFKPVNSRP
LHSFSESTMK GKISKPVVKK EATGSLFLMG SRPAPSKLNI SSSRTNVSET HSSVQGTVTN
TSTTNSALSS LYTLNKSNDD SNQKTAGVKA LPSKPLQMNS QHQSKLMEVK TTPSSTLDAI
RSSKKIRSQK RSNAEKATAK KKSFTDTTDY RSDLDSQYWL NIENPSQQSS SYADIWGRWS
HVLPPKIRRR MFKWRSLKAP AALPISTSLF PTSTQLQTDY TLQNYIITLN FENNLELKTT
RELMREMIGL RLAMGFQVCF GENIDRIEAE RKPLGNPASI IKYFPTDDCT GKKMYLSIND
EVHSIFCDYD GTLNVQMYRK IEKKDPSKIS LGSRRPHSDE NAVIRTRYAD EYTPLKIDLQ
NIKPPTFNWN QFDQLLAGYD DAITGEKAYH KMKFVVMPGD IPPNAHHINN ENLSDEEIRV
EGLRKLIALI ERGKYVQPEK QEKKSKKEEI LPEILFYTGN LYDFLGEQAE YFNVSGTKPD
NSLMVDGSRF NTNIKLQSLA QELQAPAPAG LRLVDRTWHF KLHPHCFLGN EMVSWLLEAF
DDIDSREEAT QYGQSLMERG LFRHVENRHG FLDGHYFYEF EDDYVDNSYK SRSSTSGWFR
KKGGHDGQDQ SQPSPTTPVS SNANQRRNSD NESALSGTES NPDLRRVISQ NLQIDSDSSS
LTDSQKLRRK KKFMISKHVK YNCDPLRKSF RPELLDVHYD CVHNPEHCYH IRLQWLNTST
KFIDETIINW SRVCERYGLK LVETPWSELC IIPNLNPFHS FVDLKLVLNP LTDPEFMNND
VLKTNKFYYH LHLLKKAGFL LDNRGTRFFK KDNVEICYSW GMPSFKYAQF IHKTGSYIVE
LRDNGDFFMA PNNVHILRVN TLVSSMPESS SKFNALDSQK VMLDFRESCR SKKYLREVFR
EASKNLKEEY NADFLLYT
//
