ID C4Y7Z3_CLAL4 Unreviewed; 602 AA.
AC C4Y7Z3;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=Uracil permease {ECO:0008006|Google:ProtNLM};
GN ORFNames=CLUG_04321 {ECO:0000313|EMBL:EEQ40193.1};
OS Clavispora lusitaniae (strain ATCC 42720) (Yeast) (Candida lusitaniae).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Metschnikowiaceae; Clavispora.
OX NCBI_TaxID=306902 {ECO:0000313|EMBL:EEQ40193.1, ECO:0000313|Proteomes:UP000007703};
RN [1] {ECO:0000313|EMBL:EEQ40193.1, ECO:0000313|Proteomes:UP000007703}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 42720 {ECO:0000313|EMBL:EEQ40193.1,
RC ECO:0000313|Proteomes:UP000007703};
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W., Harris D., Hoyer L.L., Hube B., Klis F.M.,
RA Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M., Nikolaou E.,
RA Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F., Sherlock G.,
RA Shah P., Silverstein K.A., Skrzypek M.S., Soll D., Staggs R.,
RA Stansfield I., Stumpf M.P., Sudbery P.E., Srikantha T., Zeng Q., Berman J.,
RA Berriman M., Heitman J., Gow N.A., Lorenz M.C., Birren B.W., Kellis M.,
RA Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the purine-cytosine permease (2.A.39) family.
CC {ECO:0000256|ARBA:ARBA00008974}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CH408080; EEQ40193.1; -; Genomic_DNA.
DR RefSeq; XP_002615439.1; XM_002615393.1.
DR AlphaFoldDB; C4Y7Z3; -.
DR GeneID; 8496325; -.
DR KEGG; clu:CLUG_04321; -.
DR VEuPathDB; FungiDB:CLUG_04321; -.
DR HOGENOM; CLU_021555_2_0_1; -.
DR InParanoid; C4Y7Z3; -.
DR OMA; YEAFAGP; -.
DR OrthoDB; 1218881at2759; -.
DR Proteomes; UP000007703; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR CDD; cd11482; SLC-NCS1sbd_NRT1-like; 1.
DR Gene3D; 1.10.4160.10; Hydantoin permease; 1.
DR InterPro; IPR012681; NCS1.
DR InterPro; IPR001248; Pur-cyt_permease.
DR InterPro; IPR045225; Uracil/uridine/allantoin_perm.
DR NCBIfam; TIGR00800; ncs1; 1.
DR PANTHER; PTHR30618:SF2; ALLANTOIN PERMEASE-RELATED; 1.
DR PANTHER; PTHR30618; NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER; 1.
DR Pfam; PF02133; Transp_cyt_pur; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007703};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 83..104
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 116..137
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 212..229
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 241..259
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 279..301
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 322..346
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 366..385
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 412..429
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 441..460
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 492..513
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 533..550
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 602 AA; 68067 MW; 137E084CC1BB4A83 CRC64;
MEEDRQDIGK TVSSKYNVRE SVDTVSVDRN SDSDSISKSE KSKWRKFLEA LEVSEPNDLT
TAQRYLFNYD LRPVEAARRQ WSWYNYVFFW IADSFNINTW MIAATGVQNG MTWWQTWLSV
WLGYTLCGIF VSISARIGVV NHISFPISVR ASFGIFFAIW PVLNRVVMSC VWYSVQAMTA
GPCIGLMLRA IFGQNLQNTM PNGIHNKNLT TFEFLSFFLF WLFSLPFLWF PPHKIRHLFT
FKAYVAPVAG VAFLVWTLVK CHGAGPVIHE KSKIHGSKFA WVFVESTMNA LANFATLITN
APDFSRFADK PTFSMKYVVQ TVSIPLCFSI TSLIGILVSS ASTVLYGETL WSPLDVLGRF
LDDYSSGSRA GVFFLGFAFA IAQLGTNISA NSLSFGTDVT ALLPQYMNIR RGSYLCALLA
LVVQPWNLLS SSSKFTTYLS AYAVFLSSIV GVICCDYYYV RRGYLKLTHL YSLFAPEDRS
IRSYYMYNKI GLNWRALVAY ICGILPNIVG FVGATSGEDK VPIGAIKVYR INFFMGFFSA
GLVYAFLCYL SPIEGTPSVK PFEKGWFEEY QDVEDFEEQL QGHIVHEGYE QSEAYSSGVL
KK
//
